Method for preparing bubble-type hollow drug delivery microneedles by tip dissolution method

Abstract

The invention discloses a method for preparing a bubble type hollow drug-delivery micro-needle through a tip dissolving method. The method for preparing a bubble type hollow drug-delivery micro-needleincludes the following steps that a metal micro-needle mold is processed and made by using a MEMS technology; a layer of 1 mm soluble micro-needle solution is poured on the surface of the metal micro-needle mold; the soluble micro-needle solution can be poured into the cavity of the micro-needle mold by vacuuming, and the redundant soluble solution on the surface of the mold is removed; the soluble solution can be dried to prepare a soluble tip layer; a PLA sheet is placed on the surface of the metal micro-needle mold, and heated to be in a melting state; melted PLA is poured into the cavityof the micro-needle mold through incomplete vacuuming, and a bubble type structure in a PLA layer is formed; a bubble micro-needle with a layered structure is obtained after cooling and demolding; thebacking layer of the micro-needle is subjected to polishing treatment so that bubbles of the backing layer explode; and a soluble layer of a micro-needle tip layer can be dissolved in skin, a remaining PLA bubble layer forms a hollow micro-needle drug-delivery channel, and the effect of continuous drug-delivery of a hollow micro-needle is achieved. The preparation process is simple and suitable for wide commercial use.

Description

technical field [0001] The invention relates to a process method for preparing a tip-dissolving air bubble hollow drug delivery microneedle by using a two-step pouring method. Background technique [0002] Common administration methods include oral administration, subcutaneous injection administration and transdermal administration. Oral administration has the advantages of being able to determine the dose in advance, easy to carry, and self-administered by patients. However, the rapid degradation of digestive enzymes in the gastrointestinal tract and the first-pass effect of the liver make the availability of most therapeutic peptides and protein drugs difficult. Reduce greatly, cause the effect of direct oral administration to have a discount greatly. Another common way of drug delivery is subcutaneous injection, which has obvious disadvantages, such as pain, discomfort and risk of infection. Microneedle transdermal drug delivery technology is a drug delivery technology ...

AI Technical Summary

Problems solved by technology

However, the manufacture of hollow microneedles requires higher precision and is easier to break, so its processing and manufacturing costs are relatively expensive

[0004] The traditional hollow microneedle preparation process usually prepares microneedles with a hollow structure directly on the substrate of a silicon wafer through chemical reaction etching. Brittle, easy to break during use, and residues in human skin will cause harm to human body

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