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Preparation method and application of self-thickening bone wound hemostatic gel

A hemostatic gel and self-thickening technology, applied in application, pharmaceutical formulation, surgery, etc., to achieve the effects of good adhesion, less composition of raw materials, and simple preparation process

Active Publication Date: 2021-11-19
BOZHOU CITY THE NEW HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, what the present invention aims to solve is the problem that the existing hemostatic materials for bone wounds cannot simultaneously have the advantages of good adhesion, plasticity, hemostatic effect, hemostatic speed and simple and easy absorption of components, thereby providing a self-thickening bone Preparation method of wound surface hemostatic gel

Method used

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  • Preparation method and application of self-thickening bone wound hemostatic gel

Examples

Experimental program
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Effect test

Embodiment 1

[0050] This example provides a self-thickening hemostatic gel for bone wounds and a preparation method thereof. The gel preparation raw materials include the following components in weight percentage:

[0051] Zwitterionic-Polysaccharide Polymer Brush 30%

[0052] Solvent base 70%

[0053] Clotting factor 0.15%.

[0054] This gel is made by following preparation method, and this preparation method comprises the following steps:

[0055] 1) Mix 2mol carboxybetaine, 0.2mol cuprous bromide and 100mol toluene at 15°C to obtain a mixture;

[0056] 2) Add 200 mol of hyaluronic acid to the mixture obtained in step 1) under nitrogen atmosphere, and react at 45° C. for 48 hours to obtain a reactant;

[0057] 3) Cool the reactant obtained in step 2) to 25° C., add it to 600 mol of absolute ethanol solution, and react at 25° C. for 24 hours to obtain a precipitate;

[0058] 4) Suction filter the precipitate obtained in step 3) at 25° C. with a vacuum of 15 Pa for 3 times, each time f...

Embodiment 2

[0062] This example provides a self-thickening hemostatic gel for bone wounds and a preparation method thereof. The gel preparation raw materials include the following components in weight percentage:

[0063] Zwitterionic-Polysaccharide Polymer Brush 35%

[0064] Solvent base 65%

[0065] Clotting factor 0.15%.

[0066] This gel is made by following preparation method, and this preparation method comprises the following steps:

[0067] 1) Mix 5 mol carboxybetaine, 0.8 mol cuprous bromide and 100 mol toluene at 25°C to obtain a mixture;

[0068] 2) Add 100 mol of hyaluronic acid to the mixture obtained in step 1) under a nitrogen atmosphere, and react at 60° C. for 48 hours to obtain a reactant;

[0069] 3) Cool the reactant obtained in step 2) to 25° C., add it to 1000 mol of absolute ethanol solution, and react at 25° C. for 48 hours to obtain a precipitate;

[0070] 4) The precipitate obtained in step 3) was suction-filtered 3 times at a vacuum degree of 12 Pa at a temp...

Embodiment 3

[0074] This example provides a self-thickening hemostatic gel for bone wounds and a preparation method thereof. The gel preparation raw materials include the following components in weight percentage:

[0075] Zwitterionic-Polysaccharide Polymer Brush 55%

[0076] Solvent base 45%

[0077] Clotting factor 0.05%.

[0078] This gel is made by following preparation method, and this preparation method comprises the following steps:

[0079] 1) Mix 2mol sulfobetaine, 1mol cuprous bromide and 100mol toluene at 10°C to obtain a mixture;

[0080] 2) In a nitrogen environment, add 50 mol of hyaluronic acid to the mixture obtained in step 1), and react at 45° C. for 48 hours to obtain a reactant;

[0081] 3) Cool the reactant obtained in step 2) to 25° C., add it to 450 mol of absolute ethanol solution, and react at 25° C. for 36 hours to obtain a precipitate;

[0082] 4) Suction filter the precipitate obtained in step 3) at a temperature of 25° C. with a vacuum degree of 15 Pa for ...

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Abstract

The invention discloses a self-thickening bone wound hemostatic gel and its preparation method and application. The gel includes a zwitterion-polysaccharide polymer brush, a solvent matrix, and blood coagulation factor components. First, the zwitterion-polysaccharide polymer brush is prepared , then, the zwitterionic-polysaccharide polymer brush is mixed with the solvent base, stirred to obtain a pre-gel, and finally, blood coagulation factors are added to the pre-gel, and stirred to obtain a self-thickening bone wound hemostatic gel, the present invention The bone wound hemostatic gel has simple components, does not need to add thickeners, excipients and other components, and has a good hemostatic effect, is easy to absorb, and does not affect wound healing.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a preparation method and application of self-thickening bone wound hemostatic gel. Background technique [0002] The hemostasis of bone wounds in orthopedic surgery, especially the hemostasis of cancellous bone wounds, has always been a difficult problem for orthopedic surgeons. The bleeding of cancellous bone wounds is often oozing blood. On the surface, there is no large amount of blood vessel rupture and rapid bleeding. However, if the hemostasis is not timely, the amount of oozing bleeding will also endanger the life of the patient. [0003] Conventional hemostatic methods such as electrocoagulation, hemostatic sponge packing, and gauze are difficult to achieve rapid hemostasis in a short period of time. At present, in clinical practice, bone wounds are mostly smeared with bone wax to seal bleeding wounds and achieve hemostatic effect. The wax components are beeswax, vase...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00C08J3/075C08L5/08C08L1/28
CPCA61L24/0015A61L24/0031A61L24/0042A61L24/08A61L24/108A61L2300/252A61L2300/418A61L2400/04C08J3/075C08J2301/28C08J2305/08C08L5/08C08L1/286
Inventor 熊良钟熊清爵阮志燕姚小祥
Owner BOZHOU CITY THE NEW HEALTH TECH CO LTD
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