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Enhanced silk fibroin artificial jaw scaffold and preparation method thereof

A silk fibroin, enhanced technology, applied in prosthetics, medical science, tissue regeneration, etc., can solve the problems of fast degradation and poor mechanical properties, and achieve moderate degradation speed, high mechanical properties, and reduce immune rejection.

Active Publication Date: 2019-11-08
杨兴华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the disadvantages of poor mechanical properties, non-directional induction to repair cells, and fast degradation of existing scaffold materials used for jaw bone repair, the present invention provides an enhanced silk fibroin artificial jaw bone carrier bracket and a preparation method thereof

Method used

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  • Enhanced silk fibroin artificial jaw scaffold and preparation method thereof
  • Enhanced silk fibroin artificial jaw scaffold and preparation method thereof
  • Enhanced silk fibroin artificial jaw scaffold and preparation method thereof

Examples

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Effect test

Embodiment 1

[0018] An enhanced silk fibroin artificial jawbone carrier bracket comprises the following components in weight percentage: 96% decalcified dentin particles, 3% silk fibroin and 1% PEG.

[0019] Among them, the particle size of decalcified dentin particles is 100um, the diameter of small tubules in decalcified dentin is 2.6um, and the Rockwell hardness value of decalcified dentin is 28.5; the number average molecular weight of silk fibroin is 60000, and the diameter is 110um; PEG number The average molecular weight is 6000.

Embodiment 2

[0021] An enhanced silk fibroin artificial jawbone carrier bracket comprises the following components in weight percentage: 92% decalcified dentin particles, 6% silk fibroin and 2% PEG.

[0022] Among them, the particle size of decalcified dentin particles is 200um, the diameter of small tubules in decalcified dentin is 2.55um, and the Rockwell hardness value of decalcified dentin is 28.7; the number average molecular weight of silk fibroin is 40000, and the diameter is 60um; PEG number The average molecular weight is 10000.

Embodiment 3

[0024] An enhanced silk fibroin artificial jawbone carrier bracket comprises the following components in weight percentage: 88% decalcified dentin particles, 9% silk fibroin and 3% PEG.

[0025] Among them, the particle size of decalcified dentin particles is 350um, the diameter of small tubules in decalcified dentin is 2.5um, and the Rockwell hardness value of decalcified dentin is 29; the number average molecular weight of silk fibroin is 20000, and the diameter is 10um; PEG number The average molecular weight is 12000.

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Abstract

The invention discloses an enhanced silk fibroin artificial jaw scaffold. The enhanced silk fibroin artificial jaw scaffold is prepared from the components in percentage by weight: 88-96% of decalcified dentin granules, 3-9% of silk fibroin and 1-3% of PEG. The enhanced silk fibroin artificial jaw scaffold can be used in bone tissue engineering, cells are combined with scaffold materials, the defects of bone source shortage, many postoperative complications, poor biocompatibility of materials and the like are overcome, so that the face of a patient is restored well and the operation cost is reduced; the domestic silkworm silk fibroin, decalcified cementum and PEG are reasonably compounded, the obtained composite scaffold has high mechanical properties, moderate degradation rate in vivo, directional osteogenic differentiation ability, no acid degradation products, and immune rejection is reduced.

Description

technical field [0001] The invention relates to oral and maxillofacial restoration, in particular to an enhanced silk fibroin artificial jawbone carrier bracket and a preparation method thereof. Background technique [0002] Jaw injury and defect are common clinical diseases in oral and maxillofacial surgery, which often cause serious facial effects and heavy economic burden to patients. The repair methods of jaw mainly include autogenous bone repair and exogenous bone repair. Autologous bone repair is the best way to repair bone defects, but there is a shortage of bone sources, and it requires secondary surgical trauma and may have corresponding complications. Exogenous bone repair comes from a wide range of sources, and it is easy to cause immune reaction, the effect is poor, and it is easy to cause infection. At present, bone tissue substitutes are mostly used in clinical jaw repair, including metals, inorganic substances, and organic materials, but they have their own ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/48A61L27/58A61L27/56
CPCA61L27/3608A61L27/58A61L27/48A61L27/3687A61L27/56A61L2430/02C08L71/02
Inventor 杨兴华
Owner 杨兴华
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