Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for detecting quality of Angelica

A detection method and technology of angelica, applied in measuring devices, instruments, scientific instruments, etc., to achieve the effect of ensuring safety and effectiveness, and good scientific data support

Active Publication Date: 2019-10-25
SHAANXI UNIV OF CHINESE MEDICINE
View PDF8 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a method for evaluating the quality markers of Angelica sinensis based on the research idea of ​​"substance-effect", and then overcome the technical problem that only a single component evaluates the quality of Angelica sinensis in practice

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting quality of Angelica
  • Method for detecting quality of Angelica
  • Method for detecting quality of Angelica

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment A kind of Angelica quality detection method

[0039] (1) Sample preparation: with reference to the "Preparation of Test Solution" method under the "Chinese Pharmacopoeia" 2015 edition of the "Angelica" content determination item, weigh about 0.2 g of Angelica powder (passed through a No. 3 sieve), and accurately weigh it. Put it in a conical flask, accurately add 20 mL of 70% methanol, weigh it, reflux it in a water bath at 85°C for 30 minutes, let it stand to cool, weigh it, add solvent to make up for the reduced weight, shake it evenly and let it stand, take the supernatant and filter it , take the filtrate for use.

[0040] (2) Fingerprint determination and composition characterization:

[0041] The data were collected by LC / MS, and the spectral data obtained by UPLC / Q-TOF-MS analysis and detection were imported into the spectral processing software to identify the compounds. Through the comparison, analysis and screening of the total ion chromatograms o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for detecting the quality of Angelica. Pharmacokinetics parameter screening standards such as a lipid-water partition coefficient, an oral bioavailability and a drug-forming property of each matching compound are referred, a compound group with excellent pharmacokinetics and high safety are subjected to second screening, and compounds are taken as 'pharmaceutical component group' associated with the efficacy of the Angelica. Then a measured in vitro / in vivo biological activity of the Angelica is used as a monitoring factor Y and the Angelica 'pharmaceutical component group' is taken as an observation factor X according to the 'substance-efficacy' interaction of the Angelica, a partial least squares regression model of the Angelica biological activity and the 'pharmaceutical component group' is established, components which are positively correlated with the Angelica biological activity and have a high correlation coefficient are found, and the components are taken as a 'quality marker' for the quality evaluation of the Angelica. Finally, a method for determining the content of the 'quality marker' of the Angelica is established by the liquid-mass spectrometry technology, and an industrialization path is provided for the overall quality traceability and control of Angelica medicinal materials or decoction pieces.

Description

technical field [0001] The invention relates to a method for detecting the quality of Angelica sinensis, in particular to a method for detecting the quality of Angelica sinensis based on the research idea of ​​"substance-effect", and belongs to the technical field of drug detection. Background technique [0002] As the basic raw materials for the production of Chinese herbal medicines and proprietary Chinese medicines, the quality of Chinese herbal medicines is the key and fundamental to ensure the quality of Chinese herbal medicines and proprietary Chinese medicines, and the standardization of Chinese herbal medicines is an important measure to ensure the quality of Chinese herbal medicines. premise. [0003] Angelica sinensis is the dry root of Angelica sinensis (Oliv.) Diels, a 2-year-old herb of the Umbelliferae. Angelica has a rich aroma, sweet, pungent, slightly bitter, with the effect of nourishing blood and promoting blood circulation, regulating menstruation and re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/02G01N30/86G01N30/72G01N30/06
CPCG01N30/02G01N30/06G01N30/72G01N30/8631G01N30/8686G01N2030/027G01N2030/047
Inventor 唐志书刘妍如宋忠兴江大海李晓红杨宁娟
Owner SHAANXI UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com