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Method for detecting quality level of traditional Chinese medicine

A detection method and quality grade technology, applied in the direction of alternative drugs, measuring devices, material inspection products, etc., can solve the problems of inability to evaluate the quality of Chinese medicine grades, etc.

Active Publication Date: 2019-10-25
SHAANXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production of traditional Chinese medicine is mostly affected by complex and changeable natural and human factors, and most of the sensory indicators, chemical indicators, and activity indicators do not show a linear correlation with the grade of medicinal materials. Inferior, unable to realize the method of industrialized traditional Chinese medicine quality grade discrimination

Method used

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  • Method for detecting quality level of traditional Chinese medicine
  • Method for detecting quality level of traditional Chinese medicine
  • Method for detecting quality level of traditional Chinese medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1 Chinese medicine cassia twig quality grade detection method

[0080] (1) Sample preparation: take about 0.3g of cassia twig powder (passed through a No. 4 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add 50mL of methanol precisely, seal it tightly, weigh it, and ultrasonically treat it (power 140w, Frequency 42kHz) for 30 minutes, let cool, weigh again, make up the lost weight with methanol, shake well, filter, take the filtrate to obtain the sample solution.

[0081] (2) Adopt ultra-high liquid chromatography to collect the integral data of cassia twig fingerprint spectrum: adopt ultra-high liquid chromatography, under the characteristic wavelength 254nm of the main component of cassia twig, use octadecylsilane bond silica gel as filler; use 0.1 % formic acid-water solution is the mobile phase A, acetonitrile is the mobile phase B, and the gradient elution is carried out according to the following conditions: time 0-2min, the volume...

Embodiment 2

[0096] Embodiment 2 Chinese medicine salvia miltiorrhiza quality grade detection method

[0097] (1) Sample preparation: Take about 0.3g of Salvia miltiorrhiza powder (passed through a No. 4 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add 50mL of methanol precisely, seal it tightly, weigh it, and ultrasonically treat it (power 140w, frequency 42kHz) for 30 minutes, let it cool down, weighed again, made up the lost weight with methanol, shaked well, filtered, and took the filtrate to obtain the sample solution.

[0098] (2) Using ultra-high liquid chromatography to collect the integral data of Danshen fingerprints: using optimized ultra-high liquid chromatography, under the characteristic wavelength of the main components of Danshen at 270nm, octadecylsilane bonded silica gel is used as filler; 0.1 % formic acid-water solution is the mobile phase A, acetonitrile is the mobile phase B, and the gradient elution is carried out according to the following co...

Embodiment 3

[0113] Embodiment 3 Chinese medicine Achyranthes bidentata quality grade detection method

[0114] (1) Sample preparation: Take about 0.3g of Achyranthes bidentata powder (passed through a No. 4 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add 50mL of methanol precisely, seal it tightly, weigh it, and perform ultrasonic treatment (power 140w, Frequency 42kHz) for 30 minutes, let cool, weigh again, make up the lost weight with methanol, shake well, filter, take the filtrate to obtain the sample solution.

[0115] (2) Collect the integrated data of Achyranthes bidentata fingerprints by ultra-high liquid chromatography: using optimized ultra-high liquid chromatography, under the characteristic wavelength of 250nm of the main components of Achyranthes bidentata, use octadecylsilane bond silica gel as filler; With 0.1% formic acid-water solution as mobile phase A and acetonitrile as mobile phase B, carry out gradient elution according to the following condit...

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Abstract

The invention discloses a method for detecting the quality level of traditional Chinese medicine. According to the technical scheme of the present invention, by establishing a correlation relationshipbetween main components and in-vitro activities of the traditional Chinese medicine, quality control index components and pharmacological activity related in-vitro activity level of the traditional Chinese medicine are determined, a sample clustering state is determined by principal component analysis, a logistic regression model between the quality level, the index components and the biologicalactivities is constructed by fitting a large number of sample data of traditional Chinese medicines of different origins and different batches, and a corresponding Chinese medicine level detection formula is established. According to the method provided by the invention, the mathematical expression of a quality difference standard of the traditional Chinese medicine can be achieved, and finally, afeasible solution path is provided for the industrialization evaluation of the quality level of a medicine or decoction piece.

Description

technical field [0001] The invention designs a method for detecting the quality level of traditional Chinese medicines, in particular relates to a method for the quality level of traditional Chinese medicines based on the interaction relationship of "ingredients-efficiency", and belongs to the technical field of traditional Chinese medicine detection. Background technique [0002] Traditional Chinese medicine resources are national strategic resources and the material basis of Chinese medicine for the survival and development of the Chinese medicine industry and the Chinese medicine industry. Therefore, the establishment of a "perfect standardization evaluation system of traditional Chinese medicine" is an important means to get rid of the embarrassing situation of uneven quality sources of traditional Chinese medicine, single quality control method of traditional Chinese medicine, and unstable curative effect level of traditional Chinese medicine. The quality standardizatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N21/25G01N30/86
CPCG01N30/02G01N30/06G01N21/25G01N30/8686G01N30/8696G01N2030/047G01N33/15G16H20/90G06F17/18G06F18/231
Inventor 刘妍如唐志书宋忠兴江大海杨宁娟常爱冰李晓红
Owner SHAANXI UNIV OF CHINESE MEDICINE
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