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Bioactive bone repair scaffold and preparation method thereof

A bioactive, bone repair technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problem that cartilage and subchondral bone cannot be repaired together, reduce cartilage degradation damage, excellent mechanical properties controllability, biological The effect of security

Active Publication Date: 2019-10-25
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem: The purpose of the present invention is to provide a bioactive bone repair scaffold and its preparation method. The internal and external structures of the scaffold can be customized, with zero addition of organic solvents, and good multi-component interface bonding, which can meet the mechanical strength requirements of cancellous bone (0.2 ~ 80Mpa), realized the material design of functional bone repair scaffolds, as well as the self-responsive release of functional ions during service, the deposition and mineralization of apatite, and solved the incompatibility of cartilage and subchondral bone in the process of joint damage repair. fix puzzle

Method used

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  • Bioactive bone repair scaffold and preparation method thereof
  • Bioactive bone repair scaffold and preparation method thereof
  • Bioactive bone repair scaffold and preparation method thereof

Examples

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Effect test

Embodiment 1

[0042] A bioactive bone repair scaffold. The bioactive bone repair scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes:

[0043] Lithium magnesium silicate 5%,

[0044] Magnesium 10%,

[0045] Degradable polymer 85%.

[0046] in:

[0047] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 85% and a pore diameter of 800 μm.

[0048] The magnesium and magnesium-lithium silicate are both granular reinforcing phases, wherein the magnesium-lithium silicate is a powder with a particle size of 50-100 μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥ 99.8 wt%, in a regular spherical shape, with a particle size of less than 40 μm .

[0049] The degradable polymer is powdery D-polylactic acid PDLA.

[0050] Its preparation steps are as follows:

[0051] S1. Pre-gel: Weigh 0.5g of magnesium lithium silicate powder, add it to 1L of deionized wa...

Embodiment 2

[0057] A bioactive bone repair scaffold. The bioactive bone repair scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes:

[0058] Lithium Magnesium Silicate 10%,

[0059] Magnesium 20%,

[0060] Degradable polymer 70%.

[0061] in:

[0062] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 80% and a pore diameter of 700 μm.

[0063] The magnesium and magnesium-lithium silicate are both granular reinforcing phases, wherein the magnesium-lithium silicate is a powder with a particle size of 50-100 μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥ 99.8 wt%, in a regular spherical shape, with a particle size of less than 40 μm .

[0064] The degradable polymer is powdered polycaprolactone PCL.

[0065] Its preparation steps are as follows:

[0066] S1. Pre-gel: Weigh 1.0g of lithium magnesium silicate powder, add it to 1L of deionized wa...

Embodiment 3

[0072] A bioactive bone repair scaffold. The bioactive bone repair scaffold uses a degradable polymer as a matrix, lithium magnesium silicate and magnesium as a reinforcing phase, and includes:

[0073] Lithium Magnesium Silicate 12%,

[0074] Magnesium 24%

[0075] Degradable polymer 64%.

[0076] in:

[0077] The bioactive bone repair scaffold is a through-hole porous scaffold with a porosity of 75% and a pore diameter of 600 μm.

[0078] The magnesium and magnesium-lithium silicate are both granular reinforcing phases, wherein the magnesium-lithium silicate is a powder with a particle size of 50-100 μm, and the magnesium powder is a high-purity magnesium powder with magnesium ≥ 99.8 wt%, in a regular spherical shape, with a particle size of less than 40 μm .

[0079] The degradable polymer is powdered poly-L-lactic acid PLLA.

[0080] Its preparation steps are as follows:

[0081] S1. Pre-gel: Weigh 1.2g of lithium magnesium silicate powder, add it to 1L of deionized ...

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Abstract

The invention discloses a bioactive bone repair scaffold and a preparation method thereof. The bioactive bone repair scaffold is prepared from, by mass, 55-85% of a degradable polymer serving as a matrix, and 5-15% magnesium lithium silicate and 10-30% of magnesium which serve as a reinforcement phase. The preparation method of the scaffold comprises the following steps of 1) preparation of magnesium lithium silicate hydrogel, 2) preparation of a mixture, 3) preparation of 3D printing raw material particles and 4) 3D printing of the bioactive bone repairing scaffold. The internal and externalstructures of the scaffold can be subjected to customized design, no organic solvent is added, the multi-component interface bonding is good, and the mechanical strength requirement(0.2-80 MPa) of thecancellous bone can be met; self-responding sustained-release of functional ions induces sedimentation of hydroxyapatite on the surface of the scaffold, the bone and cartilage injury can be synergistically repaired, customizedpreparation of the bioactive bone repair scaffold is achieved, and the application prospects of the scaffold in the field of rehabilitation treatment of the bone and cartilage injury and the like are broadened.

Description

technical field [0001] The invention relates to a bioactive bone repair bracket and a preparation method thereof, belonging to the technical field of material preparation. Background technique [0002] Bone grafting scaffolds provide new ideas for joint bone repair and regeneration. About 2.2 million bone scaffolds are used in orthopedic surgery every year in the world, mainly to stimulate new bone formation to replace and regenerate bones caused by joint trauma and disease infection. defect. Orthopedic implant products mainly include spine products, trauma products, artificial bone joint products, etc. At present, joints, trauma and spine are the three mainstream categories of orthopedic medical devices in China. With the advent of aging, bone and joint injury repair will be the fastest growing field in the future. [0003] Articular cartilage injury is one of the most challenging problems in orthopedics and sports medicine given the poor self-healing ability of articular...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/04A61L27/02A61L27/50A61L27/54A61L27/56A61L27/58B33Y10/00B33Y70/00
CPCA61L27/025A61L27/047A61L27/18A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2430/06B33Y10/00B33Y70/00C08L67/04
Inventor 白晶周星星董强胜姚庆强张明张惠康程兆俊薛烽
Owner SOUTHEAST UNIV
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