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Method for synthesizing manganese-containing nano-biomaterial and application of manganese-containing nano-biomaterial

A technology of biological nanomaterials and synthesis methods, applied in the field of biological nanomaterials, can solve problems such as multi-step complex synthesis steps, single properties, high synthesis costs, etc., and achieve enhanced therapeutic effects, simple preparation methods, and simple drug loading effects

Active Publication Date: 2019-10-18
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Importantly, divalent manganese ions can be used as better MRI contrast agents, but it is still very difficult to design and synthesize highly stable and sensitive divalent manganese complexes for clinical use.
To address this issue, many manganese-containing nanomaterials have been widely synthesized, such as manganese dioxide nanosheets, mesoporous silica-wrapped hollow manganese dioxide nanoparticles, manganese-doped zirconium metal-organic framework nanotubes, and bovine serum white Protein-stabilized manganese dioxide nanoparticles, etc., but multi-step complex synthesis steps, high synthesis costs and relatively simple properties still hinder their biomedical development

Method used

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  • Method for synthesizing manganese-containing nano-biomaterial and application of manganese-containing nano-biomaterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The synthesis of manganese-containing biological nanomaterials comprises the following steps:

[0028] (1) Escherichia coli is separated from the culture medium by centrifugation, and the centrifuged lower layer of Escherichia coli is resuspended with phosphate buffer;

[0029] (2) Escherichia coli and potassium permanganate solution (final concentration is 1mg mL –1 ) Shaker reaction for 5 minutes, followed by probe ultrasound for 15 minutes;

[0030] (3) Centrifuge the above reaction product, take the upper liquid, and perform dialysis with a dialysis bag with a molecular weight cut-off of 10 kDa to obtain pure manganese-containing bionanomaterials.

[0031] For a schematic diagram of the reaction, see figure 1 , the transmission electron microscope image of the obtained manganese-containing bionanomaterials is shown in figure 2 .

Embodiment 2

[0033] The synthesis of manganese-containing biological nanomaterials is basically the same as in Example 1, except that the Escherichia coli in step (1) is replaced with probiotics, yeast or erythrocytes.

Embodiment 3

[0035] The synthesis of manganese-containing biological nanomaterials is basically the same as in Example 1, except that step (2) is changed to a shaking table reaction for 30 minutes, followed by probe ultrasound for 60 minutes.

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Abstract

The invention discloses a method for synthesizing a manganese-containing nano-biomaterial and biomedical application of the manganese-containing nano-biomaterial. The manganese-containing nano-biomaterial is prepared from cells through potassium permanganate treatment, ultrasonic and purification. The manganese-containing nano-biomaterial has the properties of responding to glutathione and hydrogen peroxide. Furthermore, the manganese-containing nano-biomaterial can be loaded with various drugs, can be used for reducing or silencing properties of drugs, such as fluorescence, toxicity, photosensitivity, hemolysis and the like, and can controllably release an restore specific properties of the drugs under the effect of the glutathione. Therefore, the manganese-containing nano-biomaterial canbe used in catalytic oxygen generation, glutathione detection, drug delivery and the like.

Description

technical field [0001] The invention relates to a synthesis method of a manganese-containing bionano material and its biomedical application, belonging to the technical field of bionano materials. Background technique [0002] At present, there are three main methods for the synthesis of nanoparticles, namely physical method, chemical method and biosynthesis method. Among them, nanomaterials prepared by physical methods have high purity and high activity, but are easy to agglomerate; nanoparticles prepared by chemical methods have good dispersibility, but the synthesis is more complicated, there are more impurities, and the biocompatibility of the products is poor. Biosynthesis is the use of biologically mediated synthesis of nanoparticles. Compared with the first two traditional methods, the biosynthesis method is more economical and convenient, and the reaction conditions are mild. The metal nanoparticles synthesized by the biological method, such as silver, gold, platinu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P3/00A61K47/02A61K41/00A61K31/704B01J23/34A61P35/00C12R1/19C12R1/885C12R1/91
CPCA61K31/704A61K41/0057A61K47/02A61P35/00B01J23/34C12P3/00A61K2300/00
Inventor 吴富根鲍琰雯华先武
Owner SOUTHEAST UNIV
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