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Preparation method and application of xanthan gum copolymer nano micelles

A technology of nano micelles and xanthan gum, which is applied in the directions of nanotechnology, nanomedicine, nanotechnology, etc., can solve the problems such as the degree of modification is not easy to control, the molecular weight of xanthan gum is large, and the distribution of nanoparticles is wide, and the shape of micelle is achieved. The effect of good regularity, controllable particle size and good biocompatibility

Active Publication Date: 2019-10-08
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although xanthan gum itself has good chemical properties, it still has certain defects when used as an anticancer drug carrier. The molecular weight of xanthan gum is too large, the viscosity is too high in aqueous solution, and the modification reaction is difficult.
There have been some reports on the hydrophobic modification of xanthan gum. For example, through the reaction of hexadecane chloride and xanthan gum, xanthan gum can be linked to some hydrophobic groups, or the ring-opening reaction of phthalic anhydride can be used to convert hydrophobic groups into xanthan gum. The permanent phenyl group is connected with xanthan gum, but the degree of modification is not easy to control, and the distribution of the obtained nanoparticles is wide

Method used

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  • Preparation method and application of xanthan gum copolymer nano micelles
  • Preparation method and application of xanthan gum copolymer nano micelles
  • Preparation method and application of xanthan gum copolymer nano micelles

Examples

Experimental program
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Effect test

Embodiment 1

[0021] (1) Xanthan gum pretreatment: Weigh 1g of xanthan gum and add it to 200mL distilled water, stir to dissolve completely, make a solution with a mass concentration of 0.5w%, and place it in an ultrasonic environment with a power of 200W and an ultrasonic frequency of 20kHz Degrade for 2.5 hours; during the xanthan gum degradation process, use the NDJ-99 rotational viscometer to measure the dynamic viscosity of the modified xanthan gum solution, put the sample solution into a flat-bottomed centrifuge tube, select the S05 rotor, and set the rotational viscometer The parameters are used to measure the dynamic viscosity under different conditions. The viscosity measurement conditions are: 25°C, 60r / min. The initial dynamic viscosity of 0.5w% xanthan gum was 490mPa.s, which decreased to 110mPa·s after 2.5 hours of ultrasonication. Then the product is precipitated with ethanol, then dried at a constant temperature of 30°C, crushed, and sieved with a 100-mesh sieve;

[0022] (2...

Embodiment 2

[0029] Steps (1), (2) and (4) are the same as in Example 1. In step (3), the consumption of diacetone acrylamide is changed to 3 grams to obtain xanthan gum copolymer b. The remaining methods are the same to obtain xanthan gum Glue copolymer nanomicelle b1.

Embodiment 3

[0031] Steps (1), (2) and (4) are the same as in Example 1. In step (3), the consumption of diacetone acrylamide is changed to 4 grams to obtain xanthan gum copolymer c. The remaining methods are the same to obtain xanthan gum Glue copolymer nanomicelle c1.

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Abstract

The invention provides a preparation method of xanthan gum copolymer nano micelles. The preparation method comprises the following steps that after degradation, dynamic viscosity of xanthan gum with concentration of 0.5w% is reduced to 110 mPa s, then after dried, crushed and screened, the xanthan gum is dissolved in N, N-dimethyformamide, a N, N-dimethyformamide solution of 2-bromoisobutyryl bromide is added, a small amount of triethylamine is added for reaction, after obtaining brominated xanthan gum through a method of precipitation, the brominated xanthan gum is dissolved into N, N-dimethylformamide, diacetone-acryloamide is added, under the condition of no oxygen, tri[2-(dimethylamino)ethyl]amine and cuprous chloride are added to be reacted, a xanthan gum copolymer is obtained througha method of precipitation, and dissolved in a polarity organic solvent to obtain a copolymer mother solution, stirring is conducted and water is dropped into the copolymer mother solution until a micelle solution is formed, and through dialysis, the xanthan gum copolymer nano micelles are obtained. According to the preparation method, the prepared xanthan gum copolymer nano micelles have good morphological regularity, good biocompatibility and stable performance as an anti-cancer drug carrier.

Description

technical field [0001] The invention relates to a preparation method and application of xanthan gum copolymer nano micelles, belonging to the technical field of medical polymer material synthesis. Background technique [0002] Xanthan gum is an extracellular water-soluble polysaccharide secreted by Xanthomonas campestris. Because of its good biocompatibility and biodegradability, it is widely used in the fields of industry, agriculture, medicine, and daily chemical industry. In the medical field, xanthan gum is mainly used as a binder, a disintegrating agent, a sustained-release agent and a controlled-release agent. It is a component in microcapsule drug capsules and plays an important role in controlling drug release. Xanthan gum has suitable viscosity and swelling coefficient, which can prolong the gastric residence time of food and reduce blood lipid. Therefore, it is widely used in oral drug carriers and bioscaffold gels. [0003] Nanoparticles are targeted to specific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/36A61K31/4745A61K31/337A61P35/00C08F251/00C08F220/58
CPCA61K9/1075A61K47/36A61K31/4745A61K31/337A61P35/00C08F251/00C08F220/58A61K31/723C08L5/00C08B37/0033B82Y5/00A61K9/5161A61K9/14B82Y30/00B82Y40/00
Inventor 张丽萍倪才华刘仁王刚
Owner JIANGNAN UNIV
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