Gold nanoparticles activated by mercaptophenylboronic acid and preparation method and application of gold nanoparticles

Abstract

The invention provides gold nanoparticles activated by mercaptophenylboronic acid and a preparation method and application of the gold nanoparticles. The preparation method of the gold nanoparticles activated by the mercaptophenylboronic acid is simple, bacteria are prevented from being induced to generate drug resistance, and the antibacterial effect is significant; the gold nanoparticles have high biosecurity; an antibacterial fibrous membrane prepared through an electrostatic spinning method has stable physical and chemical performance and high porosity, can isolate pollutants, is soft andbreathable, has good wettability, can perfectly fit wounds of different shapes, is prepared from a degradable material and reduces the secondary damage brought by dressing replacement. The gold nanoparticles activated by the mercaptophenylboronic acid are stable and easy to store, and after the gold nanoparticles activated by the mercaptophenylboronic acid are prepared into a dressing through theelectrostatic spinning technology, high stability, the potential of large-scale production and a wide clinical application prospect are achieved.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a gold nanoparticle activated by mercaptophenylboronic acid, and a preparation method and application thereof. Background technique [0002] Bacterial infections, especially wound infections, are a serious threat to human health and even lead to death. Gram-positive bacteria are more likely to cause skin and cartilage infections than Gram-negative bacteria. In recent years, the number of patients dying from bacterial infections has increased dramatically, a phenomenon that is inseparable from the misuse of antibiotics. With the abuse of antibiotics, serious drug resistance has been induced in bacteria, leading to the superbug crisis. Therefore, it is very urgent to seek effective new antibacterial drugs, especially for multidrug-resistant superbugs. Due to the large specific surface area, high degree of surface functionalization, and unique physical and chemical...

AI Technical Summary

Problems solved by technology

The prior art discloses the preparation method of silver-loaded bacterial cellulose hydrogel antibacterial dressing and its products. The bacterial cellulose hydrogel film is soaked in the silver metal precursor solution, and antibacterial is realized through multiple steps such as washing, dehydration, and sterilization. , but the preparation process of this method is complex and nano-silver is unstable, and has strong toxicity to the human body. The US FDA has clearly prohibited the use of nano-silver in medical treatment, and my country's CFDA has also restricted nano-silver in the medical field.

The prior art also discloses a nano-gold-containing antibacterial dressing and its preparation method. An effective antibacterial agent without drug resistance to bacteria is prepared by using ligand-modified gold nanoparticles. However, when preparing an antibacterial dressing, padding and Drying and other steps, the preparation process is cumbersome and the gold nanoparticle antibacterial agent needs to be attached to other dressings, and it cannot be released slowly, so it is not suitable for long-term treatment

The prior art discloses a chitosan hydrogel for antibacterial dressings and its preparation method. The raw material components include water-soluble monomers, antibacterial agents, crosslinking agents, condensation agents, activators and initiators. The components are complex and various The influence between the components is still unclear, and the gas permeability of the wound cannot be achieved. Therefore, it is of great significance to explore functional wound dressings with simple preparation processes

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