Traditional Chinese medicine composition with efficacy of sleep improvement and preparation method
A technology for improving sleep and composition, which is applied in the field of traditional Chinese medicine composition with sleep-improving function, to achieve the effect of improving sleep effect, improving sleep quality and improving sleep
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Embodiment 1
[0021] A traditional Chinese medicine composition for improving sleep and health care food, which is prepared from the following raw materials in parts by weight: 60g of jujube seed, 60g of rehmannia glutinosa, 30g of dogwood, 30g of yam, and 30g of motherwort.
[0022] The method that utilizes above-mentioned Chinese medicine composition to prepare health food is as follows:
[0023] Step (1), water decoction: Put jujube kernels, rehmannia glutinosa, dogwood, yam, and motherwort into a decoction bag, add water and soak for 30 minutes, decoct twice, add 10 times the total weight of raw materials for decoction for the first time For 1 hour, add water 8 times the total weight of raw materials for the second time and decoct for 45 minutes, combine the two decoctions, squeeze the dregs, filter, and obtain decoction;
[0024] Step (2), concentrating and drying: heating and concentrating the water extract to an extract, freeze-drying at -40°C, and pulverizing to obtain a dry extract...
Embodiment 2
[0062] A traditional Chinese medicine composition for improving sleep health food, which is prepared from the following raw materials in parts by weight: 60g of jujube seed, 60g of rehmannia glutinosa, 40g of dogwood, 40g of yam, and 60g of motherwort.
[0063] The method that utilizes above-mentioned Chinese medicine composition to prepare health food is as follows:
[0064] Step (1), water decoction: Put jujube kernels, rehmannia glutinosa, dogwood, yam, and motherwort into a decoction bag, add water and soak for 30 minutes, decoct twice, add 10 times the total weight of raw materials for the first time and decoct For 1 hour, add water 8 times the total weight of raw materials for the second time and decoct for 45 minutes, combine the two decoctions, squeeze the dregs, filter, and obtain decoction;
[0065] Step (2), concentrating and drying: heating and concentrating the water extract to an extract, freeze-drying at -40°C, and pulverizing to obtain a dry extract powder;
...
Embodiment 3
[0103] Mice oral acute toxicity test (MTD):
[0104] 1. Animal source: Speifu (Beijing) Biotechnology Co., Ltd., KM mice, experimental animal quality certificate: No.11401500050054.
[0105] 2. Dose design: Select 40 Kunming mice of 18g~21g, half male and half male, to carry out the experiment. Animals had free access to food and water during the experiment. With a dosage of 20ml / kg BW, gavage 2 times with an interval of 6h, equivalent to 177.1g crude drug / kg BW (equivalent to 759 times the daily intake of the human body), observe continuously for 14 days, observe and record the general state of the animal, Body weight changes, signs of poisoning and death, etc., to determine the maximum tolerated dose (MTD).
[0106] 3. Way of giving samples: intragastric administration, the volume of intragastric administration is 20ml / kg BW.
[0107] 4. Test results
[0108] Mice of both genders were gavaged with test samples twice, with a dose of 177.1 g of crude drug / kg BW. During the...
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