Medical dressing for resisting bacteria and promoting wound healing and preparation method thereof

Abstract

The invention discloses a medical dressing for resisting bacteria and promoting wound healing and a preparation method thereof. The preparation method includes the following steps: preparing sodium alginate solution with a concentration of 2.0%-4.0% to obtain spinning solution; weighing 20-50 grams of silkworm raw silks, putting the silkworm raw silks into 1-3 liters of boiling Na2CO3 solution, carrying out heating and boiling, washing the silks with deionized water to obtain completely degummed silk fibroin fibers, garnetting the washed silk fibroin fibers, and drying the garnetted silk fibroin fibers for further use; weighing 5 grams of of dried silk fibroin fibers, putting the dried silk fibroin fibers in ternary solution with a bath ratio of 1: (6-12) to carry out heating in water bathand stirring to obtain silk fibroin mixed solution, cooling the silk fibroin mixed solution, carrying out dialysis with deionized water, and carrying out centrifugation to obtain fresh silk fibroin solution, thereby obtaining solidified solution; and making the spinning solution pass through a spinneret to form composite fibers with the solidified solution, subjecting the composite fibers to needle punching process to obtain needle-punched cotton, and subjecting the needle-punched cotton to moulding process to form the medical dressing. The product of the invention is soft, capable of being clinging to the wound surface and good in permeability and moisture retention, and the sodium alginate has an effect of promoting the growth of epidermis tissues, which is beneficial to the growth of new tissues, the promotion of wound healing and the alleviation of pain for patients.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a medical dressing with antibacterial properties, high absorption and the ability to promote wound healing and a preparation method thereof. Background technique [0002] Sodium alginate is a by-product of extracting iodine and mannitol from the brown algae kelp or sargassum. Its molecule is composed of β-D-mannuronic acid and α-L-guluronic acid connected by (1→4) bonds, it is a natural polysaccharide, and has the stability and solubility required for pharmaceutical preparation excipients , stickiness and safety. [0003] Silk fibroin has good biocompatibility with the human body, and as a medical material, it mostly appears in the form of silk film. "Chinese Plastic and Burn Surgery" reported in the 14th issue of 1998 that silk membranes were treated on non-infected and aseptic wounds; The physical and chemical properties of chitosan blend membrane, and pointed out ...

AI Technical Summary

Problems solved by technology

However, silk fibroin film and its composite have poor antibacterial function, poor air permeability and moisture retention, and high production cost, which affects its application.