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Tumor microenvironment responsive diagnosis and treatment integrated nano probe and preparation method thereof

A tumor microenvironment and nanoprobe technology, applied in the field of tumor microenvironment responsive diagnosis and treatment integrated nanoprobes and their preparation, can solve problems such as limitations, and achieve increased hydrophobic properties, improved enrichment, and improved imaging and imaging capabilities. The effect of therapeutic properties

Active Publication Date: 2019-09-03
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are few domestic and foreign patents and documents on the use of albumin biomineralization to construct nanoprobes and link matrix metalloproteinase-responsive peptide chains for the integration of tumor diagnosis and treatment, and they are mainly limited to hydrophobic inorganic materials. Research on Constructing Nanoprobes with Responsive Peptide Chains

Method used

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  • Tumor microenvironment responsive diagnosis and treatment integrated nano probe and preparation method thereof
  • Tumor microenvironment responsive diagnosis and treatment integrated nano probe and preparation method thereof
  • Tumor microenvironment responsive diagnosis and treatment integrated nano probe and preparation method thereof

Examples

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Embodiment 1

[0042] Take 138.6mL of nitric acid with a concentration of 65% and 806mL of deionized water, put them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a nitric acid solution with a concentration of 2moL / L for later use;

[0043]Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0044] Take 105mL of deionized water and 3.75g of bovine serum albumin and add them together into a beaker, place them in an ultrasonic disperser for dissolution and dispersion, the frequency is 50KHz, the dispersion time is 15min, and stir at room temperature for 15min to form a transparent solution; weigh bismuth nitrate pentahydrate 1.08g, slowly added to 15mL pre-prepared 2moL / L nitric acid solution, stirred for 10min, quickly added the solution to the abov...

Embodiment 2

[0047] Take 138.6mL of nitric acid with a concentration of 65% and 806mL of deionized water, put them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a nitric acid solution with a concentration of 2moL / L for later use;

[0048] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0049] Take 105mL of deionized water and 5.25g of bovine serum albumin, add them together into a beaker, place them in an ultrasonic disperser for dissolution and dispersion, the frequency is 50KHz, the dispersion time is 15min, and stir at room temperature for 15min to form a transparent solution; weigh bismuth nitrate pentahydrate 2.25g, slowly added to 15mL pre-prepared 2moL / L nitric acid solution, stirred for 10min, quickly added the solution to the above ...

Embodiment 3

[0052] Take 138.6mL of nitric acid with a concentration of 65% and 806mL of deionized water, put them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a nitric acid solution with a concentration of 2moL / L for later use;

[0053] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0054] Take 105mL of deionized water and 1.5g of bovine serum albumin, add them together into a beaker, place them in an ultrasonic disperser for dissolution and dispersion, the frequency is 50KHz, the dispersion time is 15min, and stir at room temperature for 15min to form a transparent solution; weigh bismuth nitrate pentahydrate 0.36g, slowly added to 15mL pre-prepared 2moL / L nitric acid solution, stirred for 10min, quickly added the solution to the above t...

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Abstract

The invention relates to the technical field of a biomedical nano material, and more particularly to a tumor microenvironment responsive diagnosis and treatment integrated nano probe and a preparationmethod thereof. The nano probe uses bovine serum albumin as a template and a sulfur source to construct nanoparticles having uniform dispersion and uniform particle size with Bi2S3 and MnO2 by a biomineralization mode, and an activated carboxyl group of bovine serum albumin is cross-linked with an amino group of a peptide chain to link a matrix metalloproteinase-responsive peptide chain to provide the nano probe with multimodal imaging and treatment. The material is subjected to matrix metalloproteinases in the tumor microenvironment, and the peptide chain is sheared to promote the hydrophobic chain exposure, which results increase in the hydrophobic properties of the nanoparticles, the degree of enrichment of the material in the tumor site is enhanced, which can effectively improve the imaging and therapeutic performance of the nano probe.

Description

technical field [0001] The invention relates to the technical field of biomedical nanomaterials, and more specifically, relates to a tumor microenvironment-responsive integrated nanoprobe for diagnosis and treatment and a preparation method thereof. Background technique [0002] Malignant tumors are a serious threat to human life and health. Realizing simultaneous diagnosis and treatment is one of the important means to overcome cancer. With the rapid development of nanotechnology, taking advantage of the characteristics of nanomaterials such as good biocompatibility, controllable spatial structure, and easy surface modification, the functions of targeted drug delivery, living body tracking, drug therapy, and prognosis monitoring are combined in One, bringing new hope for the integration of cancer diagnosis and treatment. [0003] Due to the rapid growth of solid tumors, the blood vessels at the tumor site are distorted and deformed, the permeability of blood vessels is inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/14A61K49/00A61K41/00A61P35/00
CPCA61K49/22A61K49/143A61K49/0019A61K49/0056A61K49/0002A61K41/0052A61P35/00
Inventor 张瑞平郑子良陈琪张重庆罗伟赵振祥
Owner SHANXI MEDICAL UNIV
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