Enzyme-free glucose electrochemical sensor and detection method thereof

A glucose and electrochemical technology, applied in chemical instruments and methods, scientific instruments, laboratory containers, etc., can solve the problems of large deviation, low sensitivity, inability to facilitate real-time detection, etc., to improve the electrocatalytic efficiency, realize the The effect of real-time detection

Active Publication Date: 2019-08-30
FUJIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the following shortcomings of the existing enzyme-free glucose electrochemical sensors: (1) It needs to be tested under alkaline conditions, and it cannot be conveniently detected in real time for near-neutral body fluids; (2) Sensitivity under near-neutral conditions (3) For the test of body fluids such as sweat and tears, it is generally necessary to extract a large number of samples through exercise, electrical stimulation, etc., and it is impossible to truly realize real-time detection

Method used

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  • Enzyme-free glucose electrochemical sensor and detection method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of working electrode, i.e., preparation of homojunction copper oxide nanofiber arrays with P-N junction properties:

[0029] (1) Print particle-free copper conductive ink to the electrode position;

[0030] (2) Porous copper conductive films were obtained by heat treatment at 80 °C for 60 min;

[0031] (3) After heat treatment at 250 °C for 120 min, a P-type copper oxide fiber array was constructed on the porous copper surface;

[0032] (4) Using oxalic acid as the electrolyte, the electrode is anodized by adding halogen (Cl - ) and adjust the pH value to 1.5 to promote the adsorption of halide ions on the surface of the copper oxide, and achieve doping with the growth of the crystal. The trapping of holes by the halogen ions is used to modify the copper oxide into an N-type semiconductor to obtain the obtained described homojunction copper oxide nanofiber arrays with P-N junction properties.

Embodiment 2

[0034] Preparation of working electrode, i.e., preparation of homojunction copper oxide nanofiber arrays with P-N junction properties:

[0035] (1) Print particle-free copper conductive ink to the electrode position;

[0036] (2) Porous copper conductive films were obtained by heat treatment at 200 °C for 1 min;

[0037] (3) After heat treatment at 400 °C for 5 min, a P-type copper oxide fiber array was constructed on the porous copper surface;

[0038] (4) Using sulfuric acid as the electrolyte, the electrode is anodized by adding halogen (Br - ) and adjust the pH value to 4, to promote the adsorption of halogen ions on the surface of copper oxide, and to achieve doping with the growth of crystals, using the trapping of holes by halogen ions, the copper oxide is modified into an N-type semiconductor to obtain the obtained described homojunction copper oxide nanofiber arrays with P-N junction properties.

Embodiment 3

[0040] Preparation of working electrode, i.e., preparation of homojunction copper oxide nanofiber arrays with P-N junction properties:

[0041] (1) Print particle-free copper conductive ink to the electrode position;

[0042] (2) Porous copper conductive films were obtained by heat treatment at 150 °C for 30 min;

[0043] (3) After heat treatment at 300 °C for 60 min, a P-type copper oxide fiber array was constructed on the porous copper surface;

[0044] (4) Using citric acid as the electrolyte, the electrode is anodized by adding halogen (F -) and adjust the pH value to 5, to promote the adsorption of halogen ions on the surface of copper oxide, and to achieve doping with the growth of crystals, using the trapping of holes by halogen ions, the copper oxide is modified into an N-type semiconductor to obtain the obtained described homojunction copper oxide nanofiber arrays with P-N junction properties.

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Abstract

The invention discloses an enzyme-free glucose electrochemical sensor and a detection method thereof. The sensor comprises a three-electrode system composed of a working electrode, a reference electrode and a counter electrode, wherein the working electrode is a homojunction copper oxide nanofiber array which is constructed on the surface of a porous Cu current collector and has a P-N junction characteristic. According to the enzyme-free glucose electrochemical sensor provided by the invention, the working electrode is designed to be the copper oxide with a homojunction characteristic constructed in situ on the surface of the porous Cu, so that the separation capacity of electrons and holes of the working electrode is improved; OH- is attached to the surface of the electrode by pre-applying a negative voltage, and a positive voltage is applied for detection; and a cation exchange membrane is used for relieving the desorption of the OH- after switching the voltage, so that high-sensitivity detection under the body fluid neutral condition is realized.

Description

technical field [0001] The invention belongs to the field of electrochemical sensors, in particular to an enzyme-free glucose electrochemical sensor and a detection method thereof. Background technique [0002] A biosensor is a device that is sensitive to biological substances and can convert biological substance concentration signals into acoustic, optical, electrical and other signals to achieve quantitative characterization and detection. Biosensor technology is widely used in biology, medicine, food, clinical, environment and other fields. Among them, glucose biosensors have excellent selectivity for glucose molecules, can quickly and directly obtain glucose concentration information in complex systems, and have rich applications in medical, environmental, industrial and agricultural applications. Glucose biosensors can be divided into enzymatic and non-enzymatic glucose sensors according to their recognition elements. [0003] Blood glucose level detection is an impor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416G01N27/327C25D11/34B01L3/00
CPCB01L3/5027C25D11/34G01N27/3278G01N27/416
Inventor 林智杰戴品强田君陈洪祥洪春福常发
Owner FUJIAN UNIV OF TECH
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