A preparation method of biomedical ordered porous cast zinc-based material

A biomedical, as-cast technology, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems that the mechanical properties cannot be compared with as-cast metal products, the bionic structure cannot be realized, and the pore structure is difficult to quantitatively control. Effects of mechanical properties and service reliability, favorable transportation, and good structural integrity

Active Publication Date: 2020-11-03
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

For the commonly used powder metallurgy method, the obtained porous material has poor connectivity between the pore structures, and the porosity is generally 30% to 70%, which cannot realize the bionic structure similar to human cancellous bone (the porosity is as high as 80% or more)
In contrast, the infiltration casting method is simple and flexible, and the obtained porous material has better pore structure connectivity and a porosity ≥ 75%, but similar to the powder metallurgy method, the pore structure of the material is difficult to achieve quantitative control according to actual needs
In addition, porous materials prepared by 3D printing technology, especially for metal materials, have more microscopic defects, and the mechanical properties are far from being comparable to cast metal products.

Method used

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  • A preparation method of biomedical ordered porous cast zinc-based material
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  • A preparation method of biomedical ordered porous cast zinc-based material

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preparation example Construction

[0040] The preparation method of the porous titanium-NaF composite preform specifically includes the following operations:

[0041] NaF slurry is composed of NaF particles, gelatin powder and supersaturated NaF aqueous solution, wherein NaF particles and gelatin are added in a mass ratio of 9:1. The mixture was placed in a stirrer and stirred at a speed of 55r / min for 30min to obtain NaF slurry;

[0042]As a preferred solution, the purity of the NaF particles is ≥99%, the particle size is 20-100 μm, and it will not cause corrosion to the zinc-based material when it is used as a preform material;

[0043] Use a uniaxial compression device to pressurize the NaF slurry to 4MPa to infiltrate the open-pore structure of porous titanium. The whole process should last at least 1 hour to ensure that the NaF slurry is completely filled;

[0044] The above composite material was heated up to 300°C at a rate of 3°C / min, sintered at a constant temperature for 5 hours, and then cooled to r...

Embodiment 1

[0058] This embodiment relates to a method for preparing an ordered porous cast zinc alloy for bone repair. The method specifically includes the following steps:

[0059] Step 1, design a porous material model with gradient pore structure by MIMICS, and its cross-sectional information is as follows figure 1 shown. Spherical titanium powder with a particle size of 35-45 μm is used as a raw material, and a porous titanium preform with a gradient pore structure is printed by SLM 250HL. During the preparation process, laser power: 20W; scanning speed: 300mm / s; scanning distance: 0.4-0.6mm ; Powder coating thickness: 10μm.

[0060] Step 2: Select NaF particles with stable chemical properties, gelatin and supersaturated NaF solution to stir slowly in a mixer for 30 minutes to obtain NaF slurry, use a compression device to fully infiltrate porous titanium, and obtain porous titanium after constant temperature sintering- NaF composite preform.

[0061] Step 3: Put the porous titani...

Embodiment 2

[0065] Step 1, use SLM 250HL to print a porous titanium preform with a pore size of 500 μm and a porosity ranging from 60% to 80%, such as figure 2 shown. Spherical titanium powder with a particle size of 30-40 μm is used as raw material, laser power during preparation: 35W; scanning speed: 500mm / s; scanning distance: 0.5mm; powder coating thickness: 20μm.

[0066] Step 2: Select chemically stable NaF particles, gelatin and supersaturated NaF aqueous solution to stir slowly in a mixer for 30 minutes to obtain NaF slurry, use a compression device to fully infiltrate porous titanium, and obtain porous titanium after constant temperature sintering- NaF composite preform.

[0067] Step 3: Put the porous titanium-NaF composite prefabricated body in a hydrogen fluoride vapor phase corrosion machine to remove the porous titanium, replace the acid mist every 24 hours, take out the prefabricated body after it is completely removed, dilute the residual material with water vapor, repea...

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Abstract

The invention discloses a method for preparing biomedical ordered and porous cast zinc-based materials, which comprises the following steps: (1) using selective laser melting (SLM) technology, according to the actual requirements of the porous cast zinc-based material structure, Prepare a porous titanium preform with the same pore structure; (2) adopt uniaxial compression, infiltrate the pre-prepared NaF slurry into the open pore structure of porous titanium, and obtain a porous titanium-NaF composite preform after it is sintered; ( 3) Put the composite preform in the environment of hydrogen fluoride (HF) acid mist, and obtain the NaF preform after the porous titanium is completely corroded; (4) use the principle of percolation casting to fill the NaF preform with zinc-based metal melt, in the air (5) Deionized water is used to dissolve and remove the NaF preform, and an ordered porous zinc-based material with excellent mechanical properties can be obtained.

Description

technical field [0001] This field belongs to the technical field of biomaterial preparation, and in particular relates to a method for preparing biomedical ordered and porous cast zinc-based materials. Background technique [0002] Large bone defects caused by trauma, infection, tumor, congenital deformity and other diseases have always been a major problem in clinical repair surgery. In the treatment of such bone defects, autologous bone or allogeneic bone transplantation is generally used, but there are still many problems such as insufficient donor materials, human immune rejection and so on. Since Vacanti et al. proposed bone tissue engineering in 1987, it has achieved rapid development as a new discipline. Bone tissue engineering is mainly by planting seed cells and biological regulatory factors on the scaffold material, and after implanting it into the bone defect site, the scaffold material degrades while the cells proliferate and differentiate, and finally achieves ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C1/08C22C18/00A61L27/04A61L27/50A61L27/56
CPCC22C1/08C22C18/00A61L27/047A61L27/56A61L27/50A61L2430/02C22C1/082
Inventor 白晶李杨徐焱程兆俊姜慧琴薛烽周健
Owner SOUTHEAST UNIV
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