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Application of nuciferine and lotus leaf extract for preparing drug for treating atrophic gastritis and/or blocking transformation of gastritis cancer

A technology of atrophic gastritis and lotus leaf extract, which is applied in the field of natural small molecule compounds of traditional Chinese medicine and traditional Chinese medicine extracts, and can solve the problems of reports of transformational therapeutic effects of digestive tract inflammation and cancer that have not been found.

Inactive Publication Date: 2019-08-16
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the literature survey has not found any reports about its transformational therapeutic effect on gastric cancer and other gastrointestinal inflammatory cancers caused by inflammation.

Method used

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  • Application of nuciferine and lotus leaf extract for preparing drug for treating atrophic gastritis and/or blocking transformation of gastritis cancer
  • Application of nuciferine and lotus leaf extract for preparing drug for treating atrophic gastritis and/or blocking transformation of gastritis cancer
  • Application of nuciferine and lotus leaf extract for preparing drug for treating atrophic gastritis and/or blocking transformation of gastritis cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: Nuciferine has the effect of treating chronic atrophic gastritis rats with intestinal metaplasia

Embodiment approach

[0055] Implementation scheme: The experimental animals were from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Select 30 specific pathogen free (SPF) grade 200±20g SD rats, half male and half male, and randomly divide them into 5 groups: normal control group, chronic atrophic gastritis (CAG) model group, The positive drug celecoxib intervention group and the two-dose intervention group of nuciferine, 6 rats in each group. Nuciferine was purchased from Chengdu Ruifensi Biotechnology Co., Ltd., with a specification of 5g and a purity of over 98%. Celecoxib was purchased from Beijing Bailingwei Technology Co., Ltd., brand J&K, with a specification of 1 g and a purity of over 98%. Sodium deoxycholate was purchased from Amresco, USA, with a specification of 100 g. Rats in model group, celecoxib intervention group and nuciferine intervention group were given sodium deoxycholate solution, ammonia water and ethanol to induce chronic atrophic gastritis in rats. Dail...

Embodiment 2

[0066] Example 2: Nuciferine and lotus leaf extract have a protective effect on gastric mucosal damage

[0067] Experimental plan: The experimental animals were from Beijing Best Biotechnology Co., Ltd., 30 SD rats of Specific pathogen Free (SPF) grade 200±20g were selected, male, and randomly divided into 5 groups: normal control group, gastric mucosa Injury model group, low-dose nuciferine group, high-dose nuciferine group and lotus leaf extract group. Nuciferine low-dose group, Nuciferine high-dose group and lotus leaf extract group were administered intragastrically for 14 consecutive days, once a day. Nuciferine was purchased from Chengdu Ruifensi Biotechnology Co., Ltd., with a specification of 5g and a purity of over 98%. The lotus leaf extract was purchased from Hebei Chenguang Biotechnology Group Handan Co., Ltd., specification: 1kg, and the content of nuciferine was above 0.4%. After the rats in the low-dose nuciferine group, the high-dose nuciferine group and the ...

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Abstract

The invention provides an application of a substance for preparing a product for treating chronic atrophic gastritis, protecting gastric mucosa and blocking the transformation of gastritis cancer. Theproduct is one selected from a medicine, a health supplement, and a food, and the substance is selected from the group consisting of a nuciferine, a derivative of nuciferine, a lotus leaf extract, and a mixture of at least two selected among the foregoing substances. The application includes at least one of treating chronic atrophic gastritis, protecting the gastric mucosa, blocking the transformation of gastritis cancer, treating pre-cancerous lesions, and preventing gastric cancer. In-vitro experiments show that nuciferine can block the proliferation of transformed cells of gastritis cancer. In-vivo experiments show that nuciferine can treat chronic atrophic gastritis in rats (especially chronic atrophic gastritis with intestinal metaplasia), nuciferine and the lotus leaf extract can protect rat gastric mucosal and inhibit the abnormal propagation of fruit fly stomach intestinal stem cells.

Description

technical field [0001] The invention belongs to the field of natural small molecular compounds of traditional Chinese medicines and traditional Chinese medicine extracts, and specifically relates to the application of nuciferine and lotus leaf extracts as medicines, health care products and food for treating chronic atrophic gastritis and / or blocking gastritis cancer transformation. Background technique [0002] Chronic inflammation is closely related to tumorigenesis [1-2]. Current epidemiological surveys and a number of scientific research results show that most tumors are caused by environmental factors and lifestyles, such as smoking, diet and infection, and these carcinogenic factors can lead to different forms of chronic inflammation[3]. More than half of the cancer-related deaths in my country are digestive system tumors, and half of the global gastric cancer is in China. Gastrointestinal tumors are closely related to various inflammations. Including esophagitis and...

Claims

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Application Information

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IPC IPC(8): A61K31/473A61K36/62A61P1/04A61P35/00A23L33/105
CPCA23L33/105A23V2002/00A61K31/473A61K36/62A61P1/04A61P35/00A61K2300/00A23V2200/32A23V2200/308A23V2250/21
Inventor 李梢
Owner TSINGHUA UNIV
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