Snore-stopping liquid and preparation method thereof

A technology of mass concentration and sinapine, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of affecting the sleep quality of patients, large side effects and high risks of western medicine, and achieve Improves stability and storage time, lubricates and softens pharyngeal mucosa, reduces respiratory resistance

Inactive Publication Date: 2019-08-13
ZHENGZHOU KANG JINRUI HEALTH PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of snoring can be performed by surgery, hormone western medicine and anti-snoring pillows. However, although the surgical treatment is fast, it has the disadvantages of significant pain, heavy bleeding, high risk, high cost, and prone to ...

Method used

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  • Snore-stopping liquid and preparation method thereof
  • Snore-stopping liquid and preparation method thereof

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preparation example Construction

[0029] The present invention also provides a preparation method of the anti-snoring liquid, comprising the following steps:

[0030] (1) Dissolving sinapine, 3-methoxy-4-hydroxycinnamic acid, ligustonin A, vitamin B17, tartaric acid and sodium bisulfite in ionized water to obtain medicinal solution A;

[0031] (2) Add medicinal charcoal to liquid A and stir for 20~40min, then filter to remove medicinal charcoal, then add Tween-80, glycerin, sodium chloride, sodium edetate, potassium sorbate and polyethylene glycol Alcohol, to obtain liquid B;

[0032] (3) Filter the medicinal solution B with a microporous membrane of 0.2-0.5 μm, then pass nitrogen gas until the nitrogen gas is saturated, and then fill and seal in the nitrogen flow to obtain the semi-finished anti-snoring solution;

[0033] (4) Sterilize the semi-finished anti-snoring solution at 110-115°C for 15-30 minutes.

[0034] Under optimal conditions, the total amount of medicinal charcoal used is 0.05-0.15 wt% of the...

Embodiment 1

[0037] A kind of anti-snoring liquid, comprising 1wt% sinapine, 0.25wt% 3-methoxyl-4-hydroxycinnamic acid, 0.12wt% ligustalactone A, 0.3wt% vitamin B17, 2.5wt% Tween-80, 15wt% glycerin, 1.2wt% sodium chloride, 0.6wt% edetate sodium, 0.03wt% potassium sorbate, 0.5wt% PEG600, 1.5wt% PEg 300, 0.003wt % tartaric acid and 0.03wt% sodium bisulfite, and the balance with ionized water.

[0038] The preparation method of the anti-snoring liquid is as follows:

[0039] (1) Dissolve 1g of sinapine, 0.25g of 3-methoxy-4-hydroxycinnamic acid, 0.12g of chuanxionglide A, 0.3g of vitamin B17, 0.3g of tartaric acid and 0.03g of sodium bisulfite in deionized water, Get liquid A;

[0040] (2) Add 1 g of medicinal charcoal to liquid A and stir for 30 minutes, then filter to remove the medicinal charcoal, then add 2.5 g of Tween-80, 15 g of glycerin, 1.2 g of sodium chloride, and 0.6 g of edide Sodium sorbate, 0.03g of potassium sorbate, 0.5g of PEG600, 1.5g of PEg 300 to obtain liquid medicine...

Embodiment 2

[0044] An anti-snoring liquid, comprising 1.2wt% sinapine, 0.36wt% 3-methoxyl-4-hydroxycinnamic acid, 0.18wt% ligustalactone A, 0.5wt% vitamin B17, 3wt% Tween-80, 12wt% glycerin, 1wt% sodium chloride, 0.5wt% edetate sodium, 0.05wt% potassium sorbate, 0.5wt% PEG600, 2wt% PEg 300, 0.003wt% Tartaric acid and 0.03wt% sodium bisulfite, the remainder and ionized water;

[0045] The preparation method of the anti-snoring liquid is as follows:

[0046] (1) Dissolve 12g of sinapine, 0.36g of 3-methoxy-4-hydroxycinnamic acid, 0.18g of Ligusticolactone A, 0.5g of vitamin B17, 0.003g of tartaric acid and 0.03g of sodium bisulfite in deionized water, Get liquid A;

[0047] (2) Add 1.5g of medicinal charcoal to liquid A and stir for 25min, then filter to remove medicinal charcoal, then add 3g of Tween-80, 12g of glycerin, 1g of sodium chloride, and 0.5g of edetic acid Sodium, 0.05g of potassium sorbate, 0.5g of PEG600, 2g of PEg 300 to obtain liquid medicine B;

[0048] (3) Filter the m...

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Abstract

The invention relates to the technical field of drug preparation, in particular to a snore-stopping liquid and a preparation method thereof. The anti-snoring liquid comprises active components, auxiliary materials and ionized water; the active components comprise sinapine, 3-methoxy-4-hydroxy cinnamic acid, senkyunolide A, vitamin B17, tween-80, glycerol, sodium chloride, sodium edetate, potassiumsorbate and polyethylene glycol. According to the anti-snoring liquid, the excitability of tissue nerves of the pharynx can be improved, the air channel can be kept open when a patient sleeps, and vortex vibration is avoided, so that the function of preventing snoring is achieved; the snore-stopping liquid is free of toxic and side effects and suitable for the patient to use for a long time; thepreparation method of the snore-stopping liquid can fully kill bacteria in the raw materials and in an injection, the stability of the anti-snoring liquid can be improved, and the storage time of theanti-snoring liquid can be prolonged.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to an anti-snoring liquid and a preparation method thereof. Background technique [0002] Snoring, also known as snoring or snoring, is a ubiquitous sleep phenomenon. Many people dismiss snoring as a common occurrence, while others view snoring as a sign of a good night's sleep. In fact, long-term snoring is caused by internal diseases. Sleeping snoring not only affects the patient's respiratory function, but also easily causes various diseases such as high blood pressure and cardiovascular and cerebrovascular diseases. It is the enemy of health. Because the airway of snorers is usually narrower than that of normal people, the throat muscles contract compensatoryly during the day to keep the airway open without blockage. However, during sleep at night, the excitability of the nerves decreases, the muscles relax, and the pharyngeal tissue is blocked, causing the upper ...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/08A61K31/192A61K31/216A61K47/02A61K47/10A61K47/12A61K47/18A61K47/26A61P11/00
CPCA61K9/08A61K31/192A61K31/216A61K31/365A61K47/02A61K47/10A61K47/12A61K47/183A61K47/26A61P11/00A61K2300/00
Inventor 张永红
Owner ZHENGZHOU KANG JINRUI HEALTH PHARMA CO LTD
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