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Preparation method of 3D printed degradable vascular stent

A 3D printing and vascular stent technology, applied in the field of 3D printing degradable vascular stents, can solve the problems of difficult vascular stents, cumbersome process, large vascular stent size, etc., and achieve the effect of reducing sequelae

Active Publication Date: 2019-08-13
陕西兴泰生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing polymer stents are extruded into tubes, and the stents are obtained by laser engraving the tubes. The process is relatively complicated. For more complex blood vessels, it is difficult to prepare corresponding vascular stents individually.
3D printing is a rapid prototyping technology. In the prior art, the model of the vascular stent is mostly prepared by 3D printing. The corresponding mold is prepared by using the model, and then the vascular stent is prepared by using the mold. The process is also relatively cumbersome. And when using the model to prepare the mold, the model will inevitably be deformed, resulting in the size of the formed vascular stent being too large or too small, which greatly reduces the accuracy of the vascular stent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: (a) Obtain morphological data of diseased blood vessels through coronary angiography or CT images, and then determine the structure of the mold core and vascular stent through three-dimensional reconstruction. The structure of the vascular stent includes wall thickness, diameter, curvature, etc. Three-dimensional structure, and establish the three-dimensional model of the core and the vascular stent respectively in the computer, and decompose the three-dimensional model into a 10um two-dimensional sheet model; wherein, the vascular stent includes a stent body and a developing ring located at both ends of the stent body, so The mold core has axial heating holes, and the wall thickness of the bracket body is 200um;

[0020] (b) Import the model data in the above step (a) into the computer of the 3D printing device, add the mixture of gelatin and sodium alginate to the feed system of the 3D printing device, wherein the weight group of gelatin and sodium alginate ...

Embodiment 2

[0023] Example 2: (a) Obtain the morphological data of diseased blood vessels through coronary angiography or CT images, and then determine the structure of the mold core and vascular stent through three-dimensional reconstruction. The structure of the vascular stent includes wall thickness, diameter, curvature, etc. Three-dimensional structure, and establish the three-dimensional model of mold core and vascular stent respectively in the computer, and decompose the three-dimensional model into a 30um two-dimensional sheet model; The mold core has axial heating holes, and the wall thickness of the bracket body is 300um;

[0024] (b) Import the model data in the above step (a) into the computer of the 3D printing device, add the mixture of gelatin and sodium alginate to the feed system of the 3D printing device, wherein the weight group of gelatin and sodium alginate The part ratio is 1:3, start the 3D printing equipment, form on the rotating receiving tube by rotating layer by ...

Embodiment 3

[0026] Example 3: (a) Obtain morphological data of diseased blood vessels through coronary angiography or CT images, and then determine the structure of the mold core and vascular stent through three-dimensional reconstruction. The structure of the vascular stent includes wall thickness, diameter, curvature, etc. Three-dimensional structure, and establish the three-dimensional model of mold core and blood vessel stent respectively in the computer, and decompose the three-dimensional model into the two-dimensional sheet model of 20um; The mold core has axial heating holes;

[0027] (b) Import the model data in the above step (a) into the computer of the 3D printing device, add the mixture of gelatin and sodium alginate to the feed system of the 3D printing device, wherein the weight group of gelatin and sodium alginate The part ratio is 1:3, start the 3D printing equipment, form on the rotating receiving tube by rotating layer by layer, and prepare a mold core with heating hole...

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Abstract

The invention discloses a preparation method of a 3D printed degradable vascular stent. The method includes the following steps that (a), three-dimensional models of a mold core and an intravascular stent are built; (b), the mold core is prepared, a gelatin layer is prepared through electrospinning, and the gelatin layer is polished to be smooth, a mixture of polylactic acid and polycaprolactone are added into clean 3D printing equipment, secondary 3D printing is performed, a stent body is printed on the gelatin layer of the mold core, and development rings are printed on the two ends of the stent body before the stent body is cured completely; (c), a liquid drug-loaded mixture is sprayed on the outer surface of the stent body through ultrasound, and the mold core is removed to obtain thehollow tubular vascular stent. Through the combination of the 3D printing technology and ultrasonic spraying, the personalized stent can be prepared, and drugs can be uniformly loaded on the stent. Moreover, the stent is made from biodegradable macromolecule materials and can degrade in vivo, and sequelae are reduced.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a method for 3D printing a degradable vascular stent. Background technique [0002] Vascular stent is a tubular device used to support narrowed and occluded blood vessels in the human body, reduce elastic recoil and reshaping of blood vessels, and maintain smooth blood flow in the lumen. Existing polymer stents are mostly extruded into tubes and laser engraved on the tubes to obtain the stents. The process is relatively complicated, and it is difficult to individually prepare corresponding vascular stents for complex blood vessels. 3D printing is a rapid prototyping technology. In the prior art, the model of the vascular stent is mostly prepared by 3D printing. The corresponding mold is prepared by using the model, and then the vascular stent is prepared by using the mold. The process is also relatively cumbersome. And when using the model to prepare the mold...

Claims

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Application Information

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IPC IPC(8): A61F2/82B33Y30/00B33Y50/00B33Y80/00
CPCA61F2/82A61F2210/0004A61F2240/001A61F2250/0067A61F2250/0098A61F2310/0097B33Y30/00B33Y50/00B33Y80/00
Inventor 何成王亮陈果王刚
Owner 陕西兴泰生物科技有限责任公司
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