Polymer composite microsphere, preparation method and drug loading application thereof
A technology of composite microspheres and polymers, applied in the direction of antineoplastic drugs, microcapsules, nanocapsules, etc., to achieve the effect of simple and easy preparation method
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Embodiment 1
[0042] According to the above technical solution, this embodiment provides a polymer composite microsphere and a preparation method.
[0043] Include the following steps:
[0044] Step 1: adding dopamine hydrochloride (DA·HCl) to the solvent and reacting in a warm water bath to prepare PDA (polydopamine) nanospheres with good light-to-heat conversion performance. Take 40mL of ethanol, 90mL of water and 3mL of concentrated ammonia water, add them to a 250mL three-necked flask in turn and stir in a 30°C water bath for 30min, maintaining a mechanical stirring rate of 250rpm. Add 0.5gDA·HCl pre-dissolved in 10mL deionized water into the three-necked flask, and react for 24h. The product was centrifuged (50000rpm, 10min), and washed with deionized water until neutral. 50 mg of PDA nanospheres were separated by centrifugation.
[0045] Step 2: using the distillation precipitation polymerization method to coat the polymer shell on the PDA nanospheres obtained in step 1 to prepare ...
Embodiment 2
[0047] Same as the method in Example 1. However, the difference from Example 1 is: accurately weigh 50 mg MAA, 1.50 mg AIBN, 5.00 mg BAC and 50 mg PDA nanospheres, and the rest of the steps are the same. Obtain polymer composite microsphere PDA@PMAA-1 (the ratio of the mass ratio of MAA and PDA is 1), such as figure 1 As shown in (c), the particle size of PDA@PMAA-1 is 190nm.
Embodiment 3
[0049] Same as the method in Example 1. However, the difference from Example 1 is: accurately weigh 100mg MAA, 3.00mgAIBN, 10mg BAC and 50mg PDA nano-microspheres, and the rest of the steps are the same. Obtain polymer composite microsphere PDA@PMAA-2 (the ratio of the mass ratio of MAA and PDA is 2), as figure 1 As shown in (d), the particle size of PDA@PMAA-2 is 227 nm.
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