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High-efficiency hypoglycemic repaglinide drug and preparation method thereof

A drug and hypoglycemic technology, applied in the field of medicine, can solve the problems of drug storage, high transportation conditions, and increase the difficulty of drugs, and achieve the effects of improving pharmacological activity, reducing production costs, and making full use of resources

Inactive Publication Date: 2019-07-26
南京瑄宇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the probiotics are directly added to the drug, in order to preserve the activity of the probiotics, it will increase the difficulty of drug preparation, and the storage and transportation conditions of the drug are relatively high

Method used

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  • High-efficiency hypoglycemic repaglinide drug and preparation method thereof
  • High-efficiency hypoglycemic repaglinide drug and preparation method thereof
  • High-efficiency hypoglycemic repaglinide drug and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A high-efficiency hypoglycemic repaglinide drug, comprising the following components in parts by mass:

[0056] Repaglinide 0.5 parts;

[0057] 1 part of liver drug enzyme inhibitor;

[0058] 3 servings of prebiotics;

[0059] 60 parts of filler;

[0060] 10 parts of adhesive;

[0061] 4 parts of disintegrant;

[0062] 4 parts plasticizer.

[0063] specifically:

[0064] The liver drug enzyme inhibitor adopts grapefruit juice. The grapefruit juice is easier to obtain and has an acceptable taste.

[0065] The prebiotic uses inulin. Inulin is currently the only prebiotic that can be extracted in large quantities from natural plants, and it is also the best plant prebiotic found so far that has all the physiological functions of oligosaccharides, so it is easier to obtain.

[0066] The filler is mannitol.

[0067] The disintegrating agent is a mixture of sodium hydroxymethyl starch and oligomeric hydroxypropyl cellulose, and their ratio is 1:1 (including this rat...

Embodiment 2

[0076] A high-efficiency hypoglycemic repaglinide drug, comprising the following components in parts by mass:

[0077] Repaglinide 1 part;

[0078] 1.5 parts of liver drug enzyme inhibitor;

[0079] 4 servings of prebiotics;

[0080] 58 parts of filler;

[0081] Adhesive 9 parts;

[0082] 5 parts of disintegrant;

[0083] 5 parts plasticizer.

[0084] specifically:

[0085] The filler is a mixture of microcrystalline cellulose and pregelatinized starch in a ratio of 2:3.

[0086] The disintegrant is croscarmellose sodium.

[0087] Described plasticizer is the mixture of polyethylene glycol and ethyl citrate, and their ratio is 3:2.

[0088] The preparation method of the above-mentioned high-efficiency hypoglycemic repaglinide drug comprises the following steps:

[0089] (I) Crush and sieve: Firstly, repaglinide, prebiotics, fillers, plasticizers and disintegrants are crushed and sieved, wherein repaglinide raw materials pass through a 120-mesh sieve, and prebiotics pass...

Embodiment 3

[0095] A high-efficiency hypoglycemic repaglinide drug, comprising the following components in parts by mass:

[0096] Repaglinide 1.5 parts;

[0097] 2 copies of liver drug enzyme inhibitor;

[0098] 4 servings of prebiotics;

[0099] 57 parts of filler;

[0100] Adhesive 8 parts;

[0101] 6 parts of disintegrant;

[0102] 6 parts of plasticizer.

[0103] specifically:

[0104] The filler is microcrystalline cellulose.

[0105] The disintegrating agent is a mixture of oligomeric hydroxypropyl cellulose and cross-linked hydroxymethyl cellulose sodium, and their ratio is 3:1.

[0106] The plasticizer is a mixture of polyethylene glycol, polysorbate and glycerol, and their ratio is 2:1:2.

[0107] The preparation method of the above-mentioned high-efficiency hypoglycemic repaglinide drug comprises the following steps:

[0108] (I) Crush and sieve: Firstly, repaglinide, prebiotics, fillers, plasticizers and disintegrants are crushed and sieved, wherein repaglinide raw ma...

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Abstract

The invention discloses a high-efficiency hypoglycemic repaglinide drug and a preparation method thereof, and belongs to the technical field of medicine. The drug comprises the following components bymass: 0.5-3 parts of repaglinide, 1-3 parts of liver drug enzyme inhibitor, 3-6 parts of prebiotics, 55-60 parts of filler, 6-10 parts of binder, 4-8 parts of disintegrant and 4-8 parts of plasticizer. The preparation method includes the steps of pulverizing, screening, granulating, wrap preparation, wrap granule sorting, molding processing and the like. A wrap granule sorting device is adopted in the wrap granule sorting step and comprises a feeding granule sorting mechanism, a wetting mechanism, a wrap mechanism and a discharge granule sorting mechanism. The drug has high-efficiency hypoglycemic effect, and is beneficial to long-term hypoglycemic conditioning of the body while applied to acute blood glucose lowering. According to the preparation method of the combined drug, the drug isdivided into two parts of a core particle and an outer layer, and the drug action mechanism requirement is met.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a high-efficiency hypoglycemic repaglinide drug and a preparation method thereof. Background technique [0002] Repaglinide is a new type of non-sulfonylurea short-acting oral insulin secretion-stimulating hypoglycemic agent. After repaglinide is absorbed through the stomach, it becomes a free active substance in the blood, which stimulates the release of insulin from the pancreas and rapidly lowers the blood sugar level. This effect depends on the functional β cells in the pancreatic islets. The difference from other oral insulin-stimulating hypoglycemic drugs is that it binds to the receptor on the β-cell, closes the APT-dependent potassium channel in the β-cell membrane, depolarizes the β-cell, opens the calcium channel, and makes the influx of calcium Increase, this process induces β cells to secrete insulin. It is used for type 2 diabetes whose high blood sugar cannot be ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K9/20A61K47/38A61K47/26A61K47/36A61K47/18A61K31/451A61K36/752A61P3/10A61J3/00
CPCA61J3/00A61K9/1617A61K9/1623A61K9/1652A61K9/167A61K9/2013A61K9/2018A61K9/2054A61K9/2086A61K31/451A61K36/752A61P3/10A61K2300/00
Inventor 钟俊生吴飞飞
Owner 南京瑄宇医药科技有限公司
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