Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of in-situ nitrogen-doped mesoporous carbon nanospheres

A nitrogen-doped mesoporous carbon and nanosphere technology, applied in the preparation/purification of carbon, can solve the problems of low adsorption efficiency of anticancer drug molecules, inability to penetrate cell membranes effectively, poor hydrophilicity, etc. The effect of releasing anticancer drugs, highly effective anticancer drugs, and improving the dissolution rate

Inactive Publication Date: 2019-06-18
GUIZHOU UNIV
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, its disadvantage is that the obtained material has a particle size of micron and cannot effectively penetrate the cell membrane.
On the other hand, since the molecular dynamics of anti-cancer active drugs is usually 1-2nm, the adsorption efficiency of anti-cancer drug molecules is extremely low if the pore size is too large
Moreover, its hydrophilicity is poor
This greatly restricts its application in anticancer drug loading and sustained release

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of in-situ nitrogen-doped mesoporous carbon nanospheres
  • Preparation method of in-situ nitrogen-doped mesoporous carbon nanospheres
  • Preparation method of in-situ nitrogen-doped mesoporous carbon nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: A kind of preparation method of in-situ nitrogen-doped mesoporous carbon nanosphere, comprises the following steps:

[0037] (1) 9.8g chitosan was dissolved in 5% acetic acid aqueous solution at 40 DEG C to prepare 2.1% chitosan solution A;

[0038] (2) 2.1g of triblock copolymer F127 was dissolved in 50ml of ethanol solution at 40°C, and then 15.6ml of tetraethyl orthosilicate TEOS (using SiO 2 Calculated as 4.2g) and 0.2M HCl (15ml) hydrolysis, obtain solution B after 10 minutes;

[0039] (3) Mix and stir solution B and chitosan solution A for 60 minutes, place it at room temperature for another 60 minutes, and dry it with a spray dryer. It is prepared under the condition that the inlet air temperature is 170°C and the feed flow rate is 3.5ml / min. powder samples;

[0040] (4) The powder obtained by the spray drying method is put into a tube furnace, and the nitrogen flow rate is 200cm 3Under the protection of / h, at room temperature, the heating rate ...

Embodiment 2

[0042] Embodiment 2: a kind of preparation method of in-situ nitrogen-doped mesoporous carbon nanospheres, comprises the following steps:

[0043] (1) 7.0g chitosan was dissolved in 5% acetic acid aqueous solution at 40 DEG C to prepare 2.1% chitosan solution A;

[0044] (2) 2.1g of triblock copolymer F127 was dissolved in 50ml of ethanol solution at 40°C, and then 15.6ml of tetraethyl orthosilicate TEOS (using SiO 2 Calculated as 4.2g) and 0.2M HCl (15ml) hydrolysis, obtain solution B after 10 minutes;

[0045] (3) Mix and stir solution B and chitosan solution A for 60 minutes, place it at room temperature for another 60 minutes, and dry it with a spray dryer. It is prepared under the condition that the inlet air temperature is 170°C and the feed flow rate is 3.5ml / min. powder samples;

[0046] (4) The powder obtained by the spray drying method is put into a tube furnace, and the nitrogen flow rate is 200cm 3 Under the protection of / h, at room temperature, the heating rat...

Embodiment 3

[0048] Embodiment 3: A kind of preparation method of in-situ nitrogen-doped mesoporous carbon nanosphere, comprises the following steps:

[0049] (1) 8.4g chitosan was dissolved in 5% acetic acid aqueous solution at 40 DEG C to prepare 2.1% chitosan solution A;

[0050] (2) 2.1g of triblock copolymer F127 was dissolved in 50ml of ethanol solution at 40°C, and then 15.6ml of tetraethyl orthosilicate TEOS (using SiO 2 Calculated as 4.2g) and 0.2M HCl (15ml) hydrolysis, obtain solution B after 10 minutes;

[0051] (3) Mix and stir solution B and chitosan solution A for 60 minutes, place it at room temperature for another 60 minutes, and dry it with a spray dryer. It is prepared under the condition that the inlet air temperature is 170°C and the feed flow rate is 3.5ml / min. powder samples;

[0052] (4) The powder obtained by the spray drying method is put into a tube furnace, and the nitrogen flow rate is 200cm 3 Under the protection of / h, at room temperature, the heating rate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of in-situ nitrogen-doped mesoporous carbon nanospheres. The preparation method includes following steps: (1), dissolving chitosan in an acetic acid watersolution to obtain a solution A; (2), dissolving three-segment copolymer F127 into an alcohol solution, adding tetraethyl orthosilicate and HCl solution to obtain a solution B; (3), mixing the solution B with the solution A, stirring, standing, and adopting a spraying dryer for drying to obtain powder; (4), putting the powder obtained in the step (3) into a tubular furnace, holding temperature of380-440 DEG C under protection of nitrogen, rising the temperature to 880-920 DEG C, and calcining to obtain a carbon-silicon composite material; (5), using NaOH water solution to desilicate the carbon-silicon composite material obtained in the step (4), using deionized water to wash to be neutral, and drying to obtain the mesoporous carbon material. The method has the advantage of being capable of preparing mesoporous carbon with small pore diameter and particle size, and obtained mesoporous carbon can effectively penetrate cytomembranes and has a function of efficiently loading and releasinganticancer drug.

Description

technical field [0001] The invention relates to a method for preparing mesoporous carbon nanospheres, in particular to a method for preparing in-situ nitrogen-doped mesoporous carbon nanospheres. Background technique [0002] The patent (CN 106744805B) uses chitosan as a carbon and nitrogen source, F127 and tetraethyl orthosilicate as a co-template, and an in-situ nitrogen-doped ultra-large pore size (17-26nm) mesoporous carbon material can be prepared by the sol-gel method. This patented method meets the requirements of environmental friendliness in the preparation process of mesoporous carbon materials and no harmful residues in biomedical materials, and has great application potential in the field of biomedicine. [0003] But its shortcoming is that the particle size of the obtained material is in the micron order and cannot effectively penetrate the cell membrane. On the other hand, since the molecular dynamics of anticancer active drugs is usually at 1-2nm, the adsorpt...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/05
Inventor 林倩潘红艳曹建新杨春亮王贤书王梦
Owner GUIZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com