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Astragaloside III nanoparticles traced by dihydroporphin fluorescence and preparation method thereof

A technology of astragalus saponins and nanoparticles is applied in the field of nano-medicine and achieves the effects of good stability, uniform size and good dispersibility

Inactive Publication Date: 2019-05-31
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no research report on the nanoparticles of astragaloside III

Method used

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  • Astragaloside III nanoparticles traced by dihydroporphin fluorescence and preparation method thereof
  • Astragaloside III nanoparticles traced by dihydroporphin fluorescence and preparation method thereof
  • Astragaloside III nanoparticles traced by dihydroporphin fluorescence and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] 1) Dissolve 20 mg of mesoporous silica nanoparticles in 1 ml of deionized water; add 2.5 mg of chlorin dissolved in dimethyl sulfoxide and 5 mg of astragaloside III, and react for 6 hours under magnetic stirring conditions;

[0029] 2) After the reaction, the filtrate was centrifuged at 6000 rpm / min for 4 minutes, washed 5 times with deionized water, and astragaloside III nanoparticles with chlorin fluorescence tracer were obtained.

Embodiment 2

[0031] 1) Dissolve 25 mg of mesoporous silica nanoparticles in 1 ml of deionized water; add 5 mg of chlorin dissolved in dimethyl sulfoxide and 10 mg of astragaloside III, and react for 6 hours under magnetic stirring conditions;

[0032] 2) After the reaction, the filtrate was centrifuged at 7000 rpm / min for 4 minutes, washed 5 times with deionized water, and astragaloside III nanoparticles with chlorin fluorescence tracer were obtained.

Embodiment 3

[0034] 1) Dissolve 30 mg of mesoporous silica nanoparticles in 1 ml of deionized water; add 7.5 mg of chlorin dissolved in dimethyl sulfoxide and 15 mg of astragaloside III, and react for 12 hours under magnetic stirring conditions;

[0035] 2) After the reaction is finished, the filtrate is centrifuged at 8000 rpm / min for 3 minutes, and washed 4 times with deionized water to obtain astragaloside III nanoparticles with chlorin fluorescence tracer.

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Abstract

The invention discloses astragaloside III nanoparticles traced by dihydroporphin fluorescence and a preparation method thereof. Mesoporous silica particles are used as a carrier to adjust the ratio ofan encapsulated dihydroporphin fluorescent dye and an astragaloside III drug to control the drug loading rate of the nanoparticles and prepare the drug-loaded nanoparticles with the particle size of80-100 nm. The dihydroporphin fluorescent dye and the astragaloside III are simultaneously encapsulated in the mesoporous silica nanoparticles to achieve both therapeutic and imaging functions. The nanoparticles can be efficiently phagocytized by tumor cells, and the problem of high clearance rate of a drug in vivo is solved. The position of the drug can be traced in real time by observing the dihydroporphin fluorescence distribution in the nano-carrier.

Description

technical field [0001] The invention relates to the technical field of nanomedicine, and more specifically relates to astragaloside III nanoparticles with chlorin fluorescence tracer and a preparation method thereof. Background technique [0002] Astragaloside III is a natural saponin compound isolated from Astragalus membranaceus, which has been shown to have anti-gastric ulcer, immunomodulatory and anti-tumor effects. Studies have shown that astragaloside III can prevent biliary liver fibrosis by inhibiting the Notch signaling pathway, thereby inhibiting the abnormal proliferation of biliary epithelial cells, and is an effective drug for the treatment of cholestatic liver diseases. Other researchers have tested its immunomodulatory ability in human tumor cell lines, indicating its great potential as an antitumor drug. [0003] However, the hydrophobicity of astragaloside III greatly limits its direct application in vivo. At present, PEG polymers with less toxicity are com...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K49/00A61K31/7048A61P1/04A61P1/16A61P35/00A61P37/02
Inventor 常津陈星濛武晓丽杨涵高俊潇
Owner TIANJIN UNIV
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