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Novel medicine composition for preventing and treating chronic gastritis and relieving diseases caused by hyperacidity and preparation method thereof

A technology for hyperacidity and chronic gastritis, which is applied in drug combinations, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as hiccups and poor medication experience of users, and achieves reduced irritation, fast onset of action, The effect of preventing the reverse dispersion of hydrogen ions

Active Publication Date: 2019-05-21
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the continuous production of gas during the neutralization reaction, users will burp frequently, and the experience of taking medicine is relatively poor; in addition, when patients with hyperacidity symptoms are delayed in seeing a doctor, they are usually accompanied by symptoms of gastric bleeding and gastritis, and the resulting symptoms Stomach pain, stomach cramps and other symptoms

Method used

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  • Novel medicine composition for preventing and treating chronic gastritis and relieving diseases caused by hyperacidity and preparation method thereof
  • Novel medicine composition for preventing and treating chronic gastritis and relieving diseases caused by hyperacidity and preparation method thereof
  • Novel medicine composition for preventing and treating chronic gastritis and relieving diseases caused by hyperacidity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0089] Lubricants can reduce the difficulty of preparation in the product preparation process, such as reducing the adsorption of the active ingredients of the material and the machine, keeping the content from falling and making the material not sticky during the tableting process.

[0090] Described lubricant is selected from and comprises one or more in talcum powder, magnesium stearate, silicon dioxide, fumed silicon dioxide, sodium lauryl sulfate; Preferably use talcum powder and magnesium stearate as lubricant . Compared with other types, the lubricating effect of the lubricant is better, and the dosage is less. It is less difficult for the lubricant to mix with the product material, and it is very easy to mix evenly.

[0091] Preferably, the lubricant is used in an amount of 10-15 parts by weight; more preferably, in the lubricant, the amount of talcum powder is 7-10 parts by weight; the amount of magnesium stearate is 3-5 parts by weight.

[0092] In the pharmaceutica...

Embodiment 1

[0140] The pharmaceutical composition for preventing and treating chronic gastritis and relieving stomach pain, heartburn and acid reflux caused by hyperacidity is prepared according to the following prescription:

[0141] ingredient name

Prescription 1

Prescription 2

Prescription 3

Gastrin

300

280

320

Aluminum hydroxide

70

60

80

aluminum magnesium carbonate

20

10

30

Woody

27

20

45

Chenpi

20

10

30

Vitamin U

25

15

35

Top eggplant liquid extract

3.3

2.5

4

Licorice Extract

67

60

80

Mannitol

80

70

90

Talc powder

8

7

10

Magnesium stearate

3.5

3

5

95% ethanol

75

70

80

[0142] Among them, the source of gastrin is Chongqing Jiangxia Biochemical Pharmaceutical Co., Ltd.;

[0143] The source of aluminum hydroxide is Shijiazhuang Wuyue P...

experiment example 1

[0167] Antacid test, the method is as follows:

[0168] Take 20 tablets, grind them finely, weigh about 0.2g, weigh them accurately, put them in a 250ml Erlenmeyer flask with a stopper, add 50ml of hydrochloric acid titration solution (0.1mol / L) precisely, seal them tightly, and heat them in a water bath at 37°C After 1 hour, shake it frequently, let it cool, add 0.5ml of bromophenol blue indicator solution, and titrate the remaining hydrochloric acid with sodium hydroxide titration solution (0.1mol / L). Measure the volume of hydrochloric acid titration solution (0.1mol / L) consumed by each tablet.

[0169] The sample detection result that makes in embodiment 1 is as follows:

[0170] Example 1

[0171] In Example 1, the antacid potencies of prescriptions 1-3 are all higher than 30ml / tablet.

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Abstract

The invention provides a novel medicine composition for preventing and treating chronic gastritis and relieving stomachache, heartburn and sour regurgitation caused by hyperacidity. The composition isa traditional Chinese medicine and western medicine compound preparation. The compound preparation mainly contains aluminum hydroxide, radix aucklandiae, a licorice root extract and a belladonna fluid extract. The composition improves the curative effect. The invention further provides a preparation method of a medicine for traditional Chinese medicine and western medicine combined treatment of chronic gastritis and diseases caused by hyperacidity. The preparation method comprises a prescription containing traditional Chinese medicine components, a preparation process of an adhesive, preparation of a soft material, preparation of wet granules and a drying technology. The production process is optimized.

Description

technical field [0001] The invention relates to a medicament for treating stomach diseases and a preparation method thereof, in particular to an integrated traditional Chinese and western medicine medicament containing Chinese medicinal ingredients in western medicine and a preparation method thereof, belonging to the field of integrated traditional Chinese and western medicine. Background technique [0002] When treating chronic gastritis and relieving stomach pain, heartburn (heartburn), acid reflux and other diseases caused by hyperacidity, chemical antacids are often used for treatment, such as aluminum magnesium carbonate tablets. The main ingredients in chemical antacids neutralize gastric acid to reduce hyperacidity, thereby alleviating or relieving the symptoms caused by hyperacidity. Due to the continuous production of gas during the neutralization reaction, users will burp frequently, and the experience of taking medicine is relatively poor; in addition, when patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K47/46A61K47/26A61K38/17A61P1/04A61K31/198A61K36/898A61K33/10A61K33/08
Inventor 傅苗青周白水
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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