A composite nanoparticle for sensitizing tumor radiotherapy and its preparation method and application

Abstract

The invention discloses a composite nanoparticle for sensitizing tumor radiotherapy and a preparation method and application of the composite nanoparticle. The composite nanoparticle comprises proteinand bismuth selenide and manganese dioxide which grow on the protein. The preparation method comprises the steps that a manganese salt solution is added into a aqueous dispersion of bismuth selenide-protein nanoparticles, after uniform mixing is carried out, a strong alkaline solution is added, the pH value is adjusted to alkaline, a heating temperature control reaction is carried out, ultrafiltration and washing are carried out, and the composite nanoparticle is obtained. The composite nanoparticle has the advantages that the water dispersibility and biocompatibility are good, radiotherapy is sensitized by increasing the local radiation dosage through bismuth selenide and improving tumor hypoxia through manganese dioxide, and computed tomography, magnetic resonance and photoacoustic multimode imaging angiography can be achieved simultaneously; the preparation method of the composite nanoparticle is simple, convenient and practical, the condition is mild, the controllability is good,and the implementation and promotion are easy; the composite nanoparticle can achieve the integration of targeted radiotherapy sensitization, diagnosis and treatment of the tumor, and has a broad application prospect in the fields of nano-medicine, disease diagnosis, tumor treatment and the like.

Description

technical field [0001] The invention belongs to the technical field of nano-composite materials, and in particular relates to a composite nano-particle for sensitizing tumor radiotherapy, a preparation method and application thereof. Background technique [0002] The incidence of malignant tumors in the world is increasing year by year, and the mortality rate has been high, which seriously threatens the survival and health of human beings. Radiation therapy, as a non-invasive tumor treatment method, is widely used in the treatment of different types of tumors. In tumor radiotherapy, after tumor cells absorb a certain amount of radiation energy, the radiation can directly interact with intracellular biomacromolecules to generate free radicals, causing DNA molecular breakage and cross-linking; radiation can also cause ionization of water molecules in tissues to generate free radicals , These free radicals react with biological macromolecules to cause cell damage and death, th...

AI Technical Summary

Problems solved by technology

Hypoxia is a common feature of most solid tumors. Hypoxia can cause radiotherapy resistance of tumor cells, increase the proportion of radiotherapy-insensitive G1 / S phase cells in tumor cells, and accelerate the repair of DNA radiation damage, reducing the risk of radiotherapy. cell killing effect

In addition, the positioning diagnosis of tumor tissue is not accurate enough, resulting in the inability to effectively distinguish tumor tissue from surrounding normal tissue during tumor radiotherapy, which will also reduce the radiotherapy efficiency and increase radiation side effects

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