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Application of shenling baizhu powder in preparing drug for treating TNBS-induced colitis

A technology of Shenling Baizhu powder and Shenling Baizhu is applied in the field of enteritis treatment, which can solve the problems of inability to achieve therapeutic effect and intestinal recovery effect, inability to effectively recover damaged colon, and without any research, and achieve recovery of carbohydrates. Metabolism, Abundance-enhancing, Abundance-enhancing effects

Inactive Publication Date: 2019-05-17
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs for the treatment of IBD, the most commonly used of which are antibiotics and hormone drugs, but most of these drugs have long-term side effects, and cannot effectively restore the damaged colon
Prior art CN201310482263.6 discloses a traditional Chinese medicine for treating colitis, but it has not been disclosed with any therapeutic effect, and there is no research on the role of intestinal flora affecting inflammation, and it is impossible to achieve a good result. Therapeutic effect and bowel restorative effect

Method used

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  • Application of shenling baizhu powder in preparing drug for treating TNBS-induced colitis
  • Application of shenling baizhu powder in preparing drug for treating TNBS-induced colitis
  • Application of shenling baizhu powder in preparing drug for treating TNBS-induced colitis

Examples

Experimental program
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Effect test

Embodiment 1

[0048] An application of Shenling Baizhu Powder in the preparation of a medicine for treating TNBS-induced colitis, wherein the Shenling Baizhu Powder medicine is an aqueous preparation, and the concentration of the Shenling Baizhu Powder medicine is 0.05g / mL.

[0049]80-100 g SD rats were selected for the experiment and purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd.

[0050] The traditional Chinese medicine compound Shenling Baizhu powder (ginseng, Poria cocos, Atractylodes macrocephala, lentils, Chinese yam, lotus meat, bellflower, coix seed, amomum, licorice) was purchased from Tongrentang Pharmaceutical Factory of Beijing Tongrentang Co., Ltd., batch number 16101034.

[0051] Wherein the modeling method of TNBS-induced colitis is specifically as follows:

[0052] 1. TNBS configuration: use 5% TNBS and 50% ethanol to prepare TNBS solution at 100mg / 2.5ml;

[0053] 2. Anesthetic preparation: solid chloral hydrate is used to prepare anesthetic, and the pr...

Embodiment 2

[0062] A kind of application of Shenling Baizhu Powder in the preparation of the medicine for the treatment of TNBS-induced colitis, wherein the Shenling Baizhu Powder medicine is an aqueous preparation, and the Shenling Baizhu Powder is a middle dose group (0.05g / mL).

[0063] Its concrete modeling and treatment method are identical with embodiment 1

Embodiment 3

[0065] A kind of application of Shenling Baizhu Powder in the preparation of the medicine for the treatment of TNBS-induced colitis, wherein the Shenling Baizhu Powder medicine is water preparation, and the Shenling Baizhu Powder medicine is a low dose group (0.10g / mL).

[0066] Its concrete modeling and treatment method are identical with embodiment 1

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Abstract

The invention discloses application of shenling baizhu powder in preparing a drug for treating TNBS-induced colitis. The shenling baizhu powder can improve the richness of an effective microbial flora, reduce the abundance of a harmful microbial flora and has a certain reduction effect on the flora diversity at the same time to achieve the flora balance of the whole intestinal environment. The shenling baizhu powder also has certain auxiliary effects on the recovery of IBD, and can also increase the abundance of various metabolic pathways and restore carbohydrate metabolism, lipid metabolism and glycan biosynthesis and metabolism of the intestinal effective microbial flora to make the metabolism normalized and alleviate the adverse effects of TNBS-induced rat IBD on the intestinal flora ofthe organism from both the flora structure and the metabolic function. The shenling baizhu powder is a traditional Chinese medicine composition which is more natural than other therapeutic drugs andhas no side effects.

Description

technical field [0001] The invention relates to the technical field of enteritis treatment, more specifically, relates to the application of Shenling Baizhu powder in the preparation of medicines for treating TNBS-induced colitis. Background technique [0002] Colitis IBD is a chronic relapsing inflammatory bowel disease. The two main types are ulcerative colitis (UC) and Crohn's disease (CD). The etiology and influencing factors of the disease are diverse. The pathogenesis and main influencing factors of the disease are still unclear. The main symptoms at the onset of colitis are bloody diarrhea, rectal prolapse, pancolitis with extensive wasting syndrome, and severe weight loss. Injured colon showed marked hyperemia, edema, multiple mucosal erosions, patchy ulcerations and marked histopathological changes including transmural inflammation, marked loss of epithelial cells and goblet cells, decreased tubular gland density and focal loss of crypts. There are multiple drugs...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K9/14A61P1/00
Inventor 周珊珊石达友刘翠谭盈姚丽丽
Owner SOUTH CHINA AGRI UNIV
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