Flexible upconversion red light sensor for living body and preparation method of sensor

Abstract

The invention discloses a flexible upconversion red light sensor for a living body and a preparation method of the sensor. The preparation method comprises the following steps: 1) preparing and representing a red light transmission upconversion microrod doped with a rare earth erbium element; and 2) preparing the flexible upconversion red light sensor: (1) pre-laying a layer of polyester film on aglass sheet, preparing polydimethylsiloxane precursors in different proportions from 10:1 to 7:1, mixing with 10 to 100 mg / ml red light transmission upconversion microrod doped with the rare earth erbium element, vacuumizing for 30 to 40 min in negative pressure of 0.03 to 0.05 MPa to debubble, and performing uniform spin-coating on a mixture on the polyester film; (2) after forming a film of 0.2to 3 mm by liquid, performing vacuum curing for 30 to 60 min at a high temperature of 80 DEG C; and (3) after cooling, compressing to avoid generating bubbles. The flexible upconversion red light sensor for the living body prepared by the invention is 25 mm<2> to 1 cm<2> in area, is capable of transmitting bright red light with a wavelength of 660 nm under excitation of 980 nm near-infrared light, can be implanted in living animal subcutaneous tissue, has relatively high red light conversion efficiency, and has relatively low biological toxicity.

Description

technical field [0001] The invention belongs to the field of biotechnology and material technology, and in particular relates to a flexible up-conversion red light sensor for a living body and a preparation method thereof. Background technique [0002] Up-conversion luminescent material is a material that absorbs long-wavelength light and emits short-wavelength light. Because of its long excitation light wavelength (980nm) and good tissue penetration, it is widely used in the treatment of living diseases , signaling pathway regulation, etc. The application methods of up-conversion materials in vivo mainly include local injection and tail vein injection, but both methods have limitations. First of all, the up-conversion material is composed of rare earth metals, and the safety of its application in living bodies needs to be carefully considered. Usually, complex surface modification methods are used to reduce its biological toxicity, such as citric acid surface modification...

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Problems solved by technology

Usually, complex surface modification methods are used to reduce its biological toxicity, such as citric acid surface modification, polyethylene glycol coating surface, etc., and excessive modification of up-conversion materials will affect its photon yield and greatly reduce the weaken its luminous efficiency; secondly, the up-conversion is gradually metabolized in the body through long-term blood circulation or body fluid circulation, and the commonly used method is multiple injections. large metabolic burden

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