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A flexible up-conversion red light sensor for living body and its preparation method

A sensor and red light technology, applied in the field of biotechnology and materials, can solve the problems of high demand, large metabolic burden of the living body, weakened luminous efficiency, etc., and achieve the effects of high biological safety, low biological toxicity, and high scientific research application prospects

Inactive Publication Date: 2021-07-06
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually, complex surface modification methods are used to reduce its biological toxicity, such as citric acid surface modification, polyethylene glycol coating surface, etc., and excessive modification of up-conversion materials will affect its photon yield and greatly reduce the weaken its luminous efficiency; secondly, the up-conversion is gradually metabolized in the body through long-term blood circulation or body fluid circulation, and the commonly used method is multiple injections. large metabolic burden

Method used

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  • A flexible up-conversion red light sensor for living body and its preparation method
  • A flexible up-conversion red light sensor for living body and its preparation method
  • A flexible up-conversion red light sensor for living body and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Fabrication of flexible up-conversion red light sensor for living body

[0028] Pre-lay a layer of polyester film on a glass sheet, configure a 10:1 polydimethylsiloxane precursor, and mix it with a red light-emitting up-conversion microrod doped with rare earth erbium element 10mg / ml, negative pressure 0.03MPa Vacuumize for 30 minutes to remove air bubbles, and evenly spin-coat the mixture on the polyester film. After the liquid film is 0.2mm thick, solidify in a vacuum at 80°C for 30 minutes. After it cools down, lay a layer of polyester film on the top layer to avoid air bubbles ( figure 1 ).

Embodiment 2

[0030] Fabrication of flexible up-conversion red light sensor for living body

[0031] Pre-lay a layer of polyester film on a glass sheet, configure a polydimethylsiloxane precursor with a ratio of 9:1, and mix it with a red light-emitting up-conversion microrod doped with rare earth erbium element 10mg / ml, negative pressure 0.03 Vacuum at MPa for 40 minutes to remove air bubbles, and evenly spin-coat the mixture on the polyester film. After the liquid is formed into a film of 1mm, it is cured at 80°C for 40 minutes at a high temperature. After cooling, lay a layer of polyester film on the top layer to avoid air bubbles.

Embodiment 3

[0033] Fabrication of flexible up-conversion red light sensor for living body

[0034] Pre-lay a layer of polyester film on a glass sheet, configure a polydimethylsiloxane precursor with a ratio of 7:1, and mix it with red light emitting up-conversion microrods doped with rare earth erbium element 100mg / ml, negative pressure 0.03 Vacuum at MPa for 40 minutes to remove air bubbles, and evenly spin-coat the mixture on the polyester film. After the liquid is formed into a film of 3mm, it is cured at 80°C for 60 minutes at a high temperature. After cooling, lay a layer of polyester film on the top layer to avoid air bubbles.

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Abstract

The invention discloses a flexible up-conversion red light sensor for living body and a preparation method thereof, comprising the following steps: 1) preparation and characterization of red light-emitting up-conversion micro-rod doped with rare earth erbium element; 2) flexible up-conversion red light sensor Preparation: (1) Pre-lay a layer of polyester film on a glass sheet, configure polydimethylsiloxane precursors in different ratios of 10:1 to 7:1, and mix with red light emission doped with rare earth erbium elements Up-conversion micro-rod 10mg / ml~100mg / ml, negative pressure 0.03MPa~0.05MPa, vacuumize for 30min~40min to remove air bubbles, spin-coat the mixture evenly on the polyester film; (2) After the liquid is formed into a film of 0.2mm~3mm , 80 ℃ vacuum high temperature curing 30min ~ 60min; (3) after it cools down to avoid bubbles. The flexible up-conversion red light sensor for living body prepared by the invention has an area of ​​25mm 2 ~1cm 2 , Under the excitation of 980nm near-infrared light, it can emit bright red light with a wavelength of 660nm, which can be embedded in the subcutaneous tissue of living animals, with high red light conversion efficiency and low biological toxicity.

Description

technical field [0001] The invention belongs to the field of biotechnology and material technology, and in particular relates to a flexible up-conversion red light sensor for a living body and a preparation method thereof. Background technique [0002] Up-conversion luminescent material is a material that absorbs long-wavelength light and emits short-wavelength light. Because of its long excitation light wavelength (980nm) and good tissue penetration, it is widely used in the treatment of living diseases , signaling pathway regulation, etc. The application methods of up-conversion materials in vivo mainly include local injection and tail vein injection, but both methods have limitations. First of all, the up-conversion material is composed of rare earth metals, and the safety of its application in living bodies needs to be carefully considered. Usually, complex surface modification methods are used to reduce its biological toxicity, such as citric acid surface modification...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00
CPCA61K49/0019A61K49/0054A61K49/0091
Inventor 王汉杰潘惠卓常津崔梅慧李佳桦
Owner TIANJIN UNIV
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