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Electrically-conductive injectable hydrogel and preparation method thereof

A technology for injecting water and gel, applied in pharmaceutical formulations, medical science, surgery, etc., can solve the problems of easy inflammatory reaction, non-degradation, poor biocompatibility, etc., and achieves simple preparation method, mild reaction conditions, and biological phase. Good capacitive effect

Inactive Publication Date: 2019-04-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Polyaniline has good conductivity, but its biocompatibility is poor, it cannot be degraded in the body, and it is easy to cause inflammation. Therefore, aniline oligomers are often used instead of polyaniline

Method used

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  • Electrically-conductive injectable hydrogel and preparation method thereof
  • Electrically-conductive injectable hydrogel and preparation method thereof
  • Electrically-conductive injectable hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Taking the oxidation degree of 50% and the aniline tetramer feed rate of 50% as an example, the preparation of conductive alginate-based injectable hydrogel is illustrated.

[0040] Weigh 5.0 g of sodium alginate and add it to 25 ml of absolute ethanol, and stir until it is evenly dispersed. Weigh 2.67g of sodium periodate, add it to 25ml of deionized water, and stir until completely dissolved in the dark (sodium periodate is easy to decompose when exposed to light, so it needs to be stirred in the dark, and the reaction should be carried out in the dark). Pour sodium periodate into the suspension of sodium alginate and react at room temperature for 4 hours. After 4h, 5ml of ethylene glycol was added to terminate the reaction for 15min. Pour the reaction solution into a dialysis bag, and perform dialysis with deionized water for three days, and change the dialysis water every day, about 3-4 times a day. The dialysis-completed product was lyophilized to obtain a white ...

Embodiment 2

[0044] Taking the oxidation degree of 70% and the aniline tetramer feed rate of 50% as an example, the preparation of conductive alginate-based injectable hydrogel is illustrated.

[0045] Weigh 5.0 g of sodium alginate and add it to 25 ml of absolute ethanol, and stir until it is evenly dispersed. Weigh 3.74g of sodium periodate, add it to 25ml of deionized water, and stir until it is completely dissolved in the dark (sodium periodate is easy to decompose when exposed to light, so it needs to be stirred in the dark, and the reaction should be carried out in the dark). Pour sodium periodate into the suspension of sodium alginate and react at room temperature for 4 hours. After 4h, 5ml of ethylene glycol was added to terminate the reaction for 15min. Pour the reaction solution into a dialysis bag, and perform dialysis with deionized water for three days, and change the dialysis water every day, about 3-4 times a day. The dialysis-completed product was lyophilized to obtain a ...

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Abstract

The invention provides an electrically-conductive injectable hydrogel and a preparation method thereof. The preparation method comprises: oxidizing the hydroxyl group on sodium alginate (ALG) into analdehyde group to obtain partially-oxidized sodium alginate (ADA), grafting an aniline tetramer (TA) onto the partially-oxidized sodium alginate by carrying out a reaction on the aldehyde group and the amino group on the aniline tetramer to obtain an aldehyde group-containing electrically-conductive macromolecular cross-linking agent partially-oxidized sodium alginate-aniline tetramer (ADA-TA), and blending the partially-oxidized sodium alginate-aniline tetramer (ADA-TA) and gelatin to obtain the electrically-conductive injectable hydrogel. According to the present invention, the preparation method is simple, the reaction condition is mild, the biocompatibility is good, and the electric conductivity of the gel can be adjusted by controlling the grafting ratio of the aniline tetramer.

Description

technical field [0001] The invention relates to the field of biomedical materials, more specifically to the preparation of a conductive, alginate-based injectable hydrogel, which utilizes the reaction of aldehyde groups on partially oxidized sodium alginate and amino groups on gelatin to form schiff Alkaline method to prepare conductive hydrogels. Background technique [0002] Sodium alginate is a by-product of extracting iodine and mannitol from brown algae kelp or sargassum, and its molecules are composed of β-D-mannuronic acid (β-D-mannuronic, M) and α-L-gulo Uronic acid (α-L-guluronic, G) is formed by linking (1 → 4) bonds. Sodium alginate contains a large amount of -COO-, which can exhibit polyanion behavior in aqueous solution and has certain adhesion, and can be used as a drug carrier for treating mucosal tissues. [0003] Under acidic conditions, -COO- transforms into -COOH, the degree of ionization decreases, the hydrophilicity of sodium alginate decreases, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L89/06C08L5/04C08B37/04A61L31/14A61L31/04
CPCA61L31/042A61L31/045A61L31/14A61L31/145A61L2400/06C08B37/0084C08J3/075C08J2389/06C08J2405/04C08L89/06C08L2203/02C08L2312/00C08L5/04
Inventor 王玮梁薇刘文广谭宝玉
Owner TIANJIN UNIV
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