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Method for preparing anti-scar coating film by using electrostatic spinning method and product and application thereof

An electrospinning method, an electrospinning technology, is applied in the field of laryngeal and tracheal postoperative scar suppression and skin surface scar coating, which can solve the problem of easy scratching, poor slow release effect, and inability to prevent and treat tracheal scars problem, to achieve the effect of good flexibility and good tensile strength

Inactive Publication Date: 2019-04-19
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The patent name is "A T-shaped tracheal intubation containing mitomycin with anti-scar function and its preparation method" and the patent number is CN201810058757. The method of conjugate coupling is used to apply the anti-scar drug on the surface of the intubation tube. Although it has a certain effect of preventing and treating scars, it is easy to scratch and has poor slow-release effect, so it cannot achieve a good effect of preventing and treating tracheal scars

Method used

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  • Method for preparing anti-scar coating film by using electrostatic spinning method and product and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An anti-scar film prepared by electrospinning is prepared according to the following steps:

[0037] (1) Preparation of spinning solution

[0038] Using silk fibroin / gelatin to make a spinning solution for nanofibers, the spinning solution with suitable physical properties can be obtained by adjusting the mass ratio of silk fibroin and gelatin. Dissolve silk fibroin / gelatin in hexafluoroisopropanol at a mass ratio of 100 / 0 to form a mixed solution of silk fibroin / gelatin with a mass fraction of 4%, place it in a glass bottle and seal it, and stir magnetically at room temperature More than 12 hours, until the solution is mixed evenly.

[0039] (2) Add carboxymethyl chitosan to the spinning solution obtained in step (1) at a concentration of 5 mg / ml, and magnetically stir until completely dissolved;

[0040] (3) Preparation of anti-scar film by electrospinning method Take a 5ml needle tube to inhale the above-mentioned spinning solution, and place it in the fixture of t...

Embodiment 2

[0042] An anti-scar film prepared by electrospinning is prepared according to the following steps:

[0043] (1) Preparation of spinning solution

[0044]Using silk fibroin / gelatin to make a spinning solution for nanofibers, the spinning solution with suitable physical properties can be obtained by adjusting the mass ratio of silk fibroin and gelatin. Dissolve silk fibroin / gelatin in hexafluoroisopropanol at a mass ratio of 175 / 25 to form a mixed solution of silk fibroin / gelatin with a mass fraction of 4%, place it in a glass bottle and seal it, and stir magnetically at room temperature More than 12 hours, until the solution is mixed evenly.

[0045] (2) Add carboxymethyl chitosan to the spinning solution obtained in step (1) at a concentration of 7 mg / ml, and magnetically stir until completely dissolved;

[0046] (3) Preparation of anti-scar film by electrospinning

[0047] Take a 5ml needle to inhale the above spinning solution, and place it in the fixture of the electrosp...

Embodiment 3

[0049] An anti-scar film prepared by electrospinning is prepared according to the following steps:

[0050] (1) Preparation of spinning solution

[0051] Using silk fibroin / gelatin to make a spinning solution for nanofibers, the spinning solution with suitable physical properties can be obtained by adjusting the mass ratio of silk fibroin and gelatin. Dissolve silk fibroin / gelatin in hexafluoroisopropanol at a mass ratio of 25 / 75 to form a mixed solution of silk fibroin / gelatin with a mass fraction of 4%, place it in a glass bottle and seal it, and stir magnetically at room temperature More than 12 hours, until the solution is mixed evenly.

[0052] (2) Add carboxymethyl chitosan to the spinning solution obtained in step (1) at a concentration of 10 mg / ml, and magnetically stir until completely dissolved;

[0053] (3) Preparation of anti-scar film by electrospinning method Take a 5ml needle tube to inhale the above-mentioned spinning solution, and place it in the fixture of ...

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Abstract

The invention relates to a method for preparing an anti-scar coating film by using an electrostatic spinning method and a product and application thereof. The method combines a medicament for inhibiting cell fibrosis damage with the electrostatic spinning technology to obtain the coating film capable of inhibiting postoperative scars and skin wound scars of a laryngeal trachea, firstly, preparinga spinning solution, then adding carboxymethyl chitosan into the spinning solution at a concentration of 5-10mg / ml, and finally, preparing the anti-scar coating film by an electrostatic spinning method. The method adopts an electrostatic spinning method to prepare the nanofiber film, which has good flexibility and tensile strength, and is an excellent film coating material; According to the invention, the medicament can be slowly released through the nanofiber, and an ideal treatment effect can be achieved on scar prevention.

Description

technical field [0001] The invention relates to a method for preparing an anti-scar film by electrospinning method and its product and application. Specifically, the drug capable of inhibiting cell fibrosis damage is combined with the electrospinning technology to obtain a drug capable of inhibiting laryngotracheal postoperative scars. , The coating of the scar on the skin surface. The invention belongs to the field of medical biology. Background technique [0002] Nanotechnology has great potential in creating new materials with advanced applications, and nanofibers have excellent properties unmatched by ordinary fibers due to their high surface area and porosity due to their fiber diameters less than 100 nm. Electrospinning technology (Electrospinning) is a textile technology that uses electrostatic force as a traction force to prepare ultrafine fibers. This technology can spin ultrafine fibers with a fiber diameter as small as 1nm. The electrospinning process has many u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/62A61L15/42A61L15/44A61L15/28A61L15/32D01F8/02D01F1/10D04H1/728D01D5/00
CPCA61L15/225A61L15/42A61L15/44A61L15/62A61L2300/232A61L2300/412A61L2400/12D01D5/003D01F1/10D01F8/02D04H1/728C08L89/00C08L5/08
Inventor 何丹农王萍周如鑫严一楠陈益金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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