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Preparation method and application of H1, H2 or J type astaxanthin aggresome water dispersion system

A dispersion system, astaxanthin technology, applied in the fields of food, chemical industry, and medicine, can solve the problems of single color of solution, instability of free astaxanthin, uncontrollable microstructure of water-dispersed astaxanthin, etc.

Active Publication Date: 2019-04-19
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems that astaxanthin is difficult to dissolve in water and the color of the solution is single, the instability of free astaxanthin, and the uncontrollable microstructure of water-dispersed astaxanthin. Construct a stable microenvironment of astaxanthin aggregation state, and provide a preparation method for water dispersion system of H1 type or H2 type or J type astaxanthin aggregates that can control the formation of three colors

Method used

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  • Preparation method and application of H1, H2 or J type astaxanthin aggresome water dispersion system
  • Preparation method and application of H1, H2 or J type astaxanthin aggresome water dispersion system
  • Preparation method and application of H1, H2 or J type astaxanthin aggresome water dispersion system

Examples

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Effect test

Embodiment 1

[0070] Example 1 Preparation of Yellow H1 Type Astaxanthin Aggregate Aqueous Dispersion System

[0071] Take an eggplant-shaped bottle with a capacity of 1000 mL, put the rotor in it, fix it on a magnetic stirrer, and set the rotation speed at 300 rpm; Astaxanthin ethanol solution 30 mL, chitosan (deacetylation degree 90.3%, molecular weight 80 kD) solution 160 mL at a concentration of 0.02 mg / mL, stirred by magnetic force for 30 min; then salmon at a concentration of 0.02 mg / mL was added to the mixed system A total of 80 mL of the refined DNA solution was added within 10 min, and the magnetic stirring was continued for 15 min; the rotary evaporator was turned on, and the condensation temperature was set to -15°C, the temperature of the water bath was 25°C, and the rotation speed was 50 rpm; After the reaction system was rotated to remove ethanol at a vacuum of 8 mbar, an equal volume of 1% chitosan (deacetylation degree 92%, molecular weight 5 kD) was added to obtain yellow H...

Embodiment 2

[0072] Example 2 Preparation of Orange H2 Type Astaxanthin Aggregate Water Dispersion System

[0073]Take an eggplant-shaped bottle with a capacity of 1000 mL and place the rotor in it, fix it on a magnetic stirrer, and set the rotation speed at 300 rpm; pour chitosan with a concentration of 0.02 mg / mL into the eggplant-shaped bottle in turn (degree of deacetylation 90.3%, molecular weight 80 kD) solution 160 mL, add sodium chloride solution with a final concentration of 5 mg / mL to it, stir well, add 0.01 mg / mL astaxanthin ethanol solution that dissolves and stand for 3 days 30 mL, magnetic stirring for 3 min; then add 80 mL of salmon sperm DNA solution with a concentration of 0.02 mg / mL into the mixing system and control the addition within 10 min, continue magnetic stirring for 15 min; turn on the rotary evaporator, set The condensing temperature is -15°C, the temperature of the water bath is 25°C, and the rotation speed is 50 rpm; the mixed reaction system is rotated under ...

Embodiment 3

[0074] The preparation of the J-type astaxanthin aggregate water dispersion system of embodiment 3 pink

[0075] Take an eggplant-shaped bottle with a capacity of 1000 mL, place the rotor in it, fix it on a magnetic stirrer, and set the speed at 300 rpm; add 80 mL of ethanol solution of astaxanthin dissolved and left for 12 h to the eggplant-shaped bottle in turn (0.007 mg / mL), 0.02 mg / mL chitosan (deacetylation degree 90.3%, molecular weight 80 kD) solution 160 mL, magnetically stirred for 30 min; then add 0.02 mg / mL salmon essence A total of 80 mL of DNA solution was added within 10 min, and magnetic stirring was continued for 15 min; the rotary evaporator was turned on, and the condensation temperature was set to -15°C, the water bath temperature was 25°C, and the rotation speed was 50 rpm; the mixed reaction After the system was evaporating under 8 mbar vacuum to remove ethanol, an equal volume of 1% chitosan oligosaccharide (deacetylation degree 92%, molecular weight 5 kD...

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Abstract

The invention discloses a preparation method and application of an H1, H2 or J type astaxanthin aggresome water dispersion system. Natural biological macro chitosan and special molecular structures offish sperm DNA are adopted by astaxanthin aggresome water dispersion systems with three colors to induce the formation and stabilizing of an astaxanthin polymer through physical interaction among macro molecules combining with a solvent and a salt ion effect. Ethanol with low toxicity is taken as the astaxanthin good solvent, the organic solvent can be completely removed in the later period of the preparation process and can be further enriched and recycled to facilitate clean production and the reduction of cost. The H1, H2 or J type astaxanthin aggresome water dispersion system can be controlled by regulating technological parameters to allow the developing range of astaxanthin waterborne product to be expanded to yellow, orange and pink, and a stable aggregation state and developing effect of the astaxanthin are maintained in concentration, dehydration and reconstitution process. The preparation technology of the three kinds of the astaxanthin aggresome water dispersion systems issimple, the reaction conditions are mild, the production cost is low, the technology is green and has no pollution, and therefore industrial popularization is convenient.

Description

technical field [0001] The present invention relates to a water-soluble aggregated astaxanthin stable water dispersion system, specifically to prepare three kinds of astaxanthin H1, H2 or J-type aggregates with controllable aggregation states. The invention discloses a water dispersion system of type astaxanthin aggregates, which belongs to the technical fields of food, medicine and chemical industry. Background technique [0002] Astaxanthin widely exists in nature, such as plant flowers, leaves, fruits, crustaceans, fish, algae and other tissues. As a fat-soluble pigment, astaxanthin not only has bright color and strong antioxidant activity, but is widely used in farming, daily chemical and medical health industries. Among them, the natural astaxanthin derived from Haematococcus pluvialis is the strongest antioxidant found in nature so far, and it is also the only carotenoid that can pass through the blood-brain barrier, so it can be used as a dietary supplement, food add...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K47/02A61K47/26A61K47/36A61P39/06A23K20/179A23L5/42A23L33/10
CPCA61K47/02A61K47/26A61K47/36A61P39/06A23K20/179A23L5/42A23L33/10A61K31/122A23K20/153A23K20/163A23L5/44A23L33/105A23L33/13A23V2002/00A23V2200/044A23V2250/211A23V2250/511
Inventor 薛长湖李敬代明琴常耀光梁兴国徐杰杨鲁
Owner OCEAN UNIV OF CHINA
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