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Circulating miRNA marker related to auxiliary diagnosis of endometrial cancers and application thereof

An endometrial cancer, auxiliary diagnosis technology, applied in the fields of genetic engineering and oncology, can solve the problem of inconsistent research results, and achieve the effect of high sensitivity and specificity, easy access, and minimally invasive access.

Active Publication Date: 2019-04-12
朱伟
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  • Abstract
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Problems solved by technology

However, due to differences in research methods and included populations, the results of the studies were not completely consistent.

Method used

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  • Circulating miRNA marker related to auxiliary diagnosis of endometrial cancers and application thereof
  • Circulating miRNA marker related to auxiliary diagnosis of endometrial cancers and application thereof
  • Circulating miRNA marker related to auxiliary diagnosis of endometrial cancers and application thereof

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Embodiment Construction

[0040] From 2015 to 2016, the inventor collected a large number of venous plasma and serum samples from the First Affiliated Hospital of Nanjing Medical University and Nanjing Maternal and Child Health Care Hospital. 181 cases of endometrial cancer and 197 samples of normal controls were selected as the experimental samples for the initial screening of Exiqon miRNA qPCR panel chip and subsequent series of qRT-PCR verification. At the same time, 24 cases of endometrial cancer tissues and 24 cases of paracancerous tissues were retained. The selected patients' plasma and serum samples were all from newly diagnosed patients who had not undergone surgery, radiotherapy and chemotherapy intervention and were pathologically confirmed as endometrial cancer. The demographic data and clinical data of these samples were collected systematically.

[0041] Refer to the flowchart ( figure 1 and figure 2 ), randomly selected 20 samples of endometrial cancer and 10 samples of normal contro...

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Abstract

The present invention discloses a circulating miRNA marker related to auxiliary diagnosis of endometrial cancers and an application thereof. The marker is one or more of plasma markers of miR-142-3p,miR-146a-5p and miR-151a-5p and serum markers of miR-143-3p, miR-195-5p, miR-20b-5p, miR-204-5p, miR-423-3p and miR-484. As a novel biomarker, the circulating miRNA has characteristics of being good in stability, minimally invasive, easy to acquire, and high in sensitivity and specificity. The development and utilization of the molecular markers provide new directions for diagnosis and further treatment of various diseases including tumors. A study is more targeted to obtain the circulating miRNA marker for the endometrial cancers with a clinical diagnostic potential. The study confirms reliability and reproducibility of the group of the miRNAs as a non-invasive marker for the diagnosis of the endometrial cancers.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and oncology, and relates to a circulating miRNA marker related to the auxiliary diagnosis of endometrial cancer and its application. Background technique [0002] Endometrial cancer (EC) is one of the most common female malignancies in the world. According to Cancer Statistics in 2018, endometrial cancer is the sixth leading cause of death in women. Although more than 70% of patients are diagnosed at an early stage, most patients still die due to many factors, including late surgical stage, distant metastasis, treatment resistance and recurrence, and the 5-year survival rate is less than 40%. Moreover, pelvic examination, transvaginal B-ultrasound and tumor markers, such as carbohydrate antigen 125 (CA125), have been widely used clinically, but they are still not enough to completely detect the disease early and reduce the mortality rate of endometrial cancer. With the development of biotech...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 朱伟陈彦贾雪梅殷茵周鑫张获单霞夏添松邹璇
Owner 朱伟
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