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Drug for neuroendocrine tumors and process thereof

A neuroendocrine and tumor technology, applied in the field of medicine and technology for neuroendocrine tumors, can solve the problems of patients’ physical function damage and poor treatment effect, and achieve the effects of enhancing targeting ability, reducing leakage, and reducing side effects

Pending Publication Date: 2019-04-02
南京苏睿医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing drugs for neuroendocrine tumors have poor treatment effects, and the drugs have great side effects. While treating patients, they will also cause damage to other body functions of the patients, and cannot effectively inhibit the growth of tumor cells.

Method used

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  • Drug for neuroendocrine tumors and process thereof
  • Drug for neuroendocrine tumors and process thereof

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Embodiment Construction

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] A drug for neuroendocrine tumors, specifically including the following raw materials: cysteamine hydrochloride, Boc2O, TPE-NHS, Boc-SS-NH2, HOOC-PEG5k-NH2, BLG-NCA, NHS, octreotide, 3-aminobenzene Boric acid and ETO.

[0026] In a preferred embodiment, the concentration of cysteamine hydrochloride is 8.9mmol, the concentration of Boc2O is 9.2mmol, the concentration of TPE-NHS is 2.1mmol, and the concentration of Boc-SS-NH2 is 3.2mmol, the concentration of the HOOC-PEG5k-NH2 is 0.2mmol, and the concentration of the BLG-NCA is...

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Abstract

The invention discloses a drug for neuroendocrine tumors and a process thereof, and specifically relates to the field of biopharmaceuticals, wherein the drug includes the following raw materials: cysteamine hydrochloride, Boc2O, TPE-NHS, Boc-SS-NH2, HOOC-PEG5k-NH2, BLG-NCA, NHS, octreotide, 3-aminophenylboric acid and ETO. With phenylborate bonds contained in the drug, micelles can maintain structural stability in blood circulation, thereby protecting an encapsulated drug, reducing drug leakage, and reducing systemic toxic and side effects. When the drug-loaded micelles are gathered in tumor tissues through the EPR effect, octreotide on the surface of the micelles can specifically bind to the overexpressed somatostatin acceptors of neuroendocrine tumor cells, so as to enhance the targetingability of the micelles.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, and more specifically, the invention relates to a medicine and technology for neuroendocrine tumors. Background technique [0002] Neuroendocrine tumors are tumors that arise from neuroendocrine cells. Neuroendocrine cells are a large class of cells that have neuroendocrine phenotypes and can produce a variety of hormones in the body. Neuroendocrine cells are distributed throughout the body, so neuroendocrine tumors can occur anywhere in the body, but the most common are neuroendocrine tumors of the digestive system such as the stomach, intestines, and pancreas, accounting for about 2 / 3 of all neuroendocrine tumors. The incidence of neuroendocrine tumors in European and American populations is 2.5-5 per 100,000 people, and the incidence has increased by 5 times in the past 30 years. Compared with other tumors, the incidence of neuroendocrine tumors has increased more rapidly. [0003] Drug the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K9/107A61K47/34A61K47/42A61K31/7048A61P35/00
CPCA61K9/1075A61K31/7048A61K47/34A61K47/42A61K49/0021A61K49/0082A61P35/00
Inventor 张立竹赵玮张玉虎陈天冬
Owner 南京苏睿医药科技有限公司
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