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Application of echinocystic acid in preparation of drugs for treating cerebral infarction

A technology of echinocystic acid and cerebral infarction, applied in the application field of echinic acid in the preparation of drugs for the treatment of cerebral infarction, to achieve the effect of reducing nerve tissue death, reducing neurological deficit, and reducing the volume of cerebral infarction

Inactive Publication Date: 2019-04-02
于海龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no research has yet confirmed that EA has a recovery effect on cerebral ischemia-reperfusion nerve injury and long-term functional improvement.

Method used

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  • Application of echinocystic acid in preparation of drugs for treating cerebral infarction
  • Application of echinocystic acid in preparation of drugs for treating cerebral infarction
  • Application of echinocystic acid in preparation of drugs for treating cerebral infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Effect of Example 1 on Neurobehavioral Scores of Mice After Cerebral Hemorrhage

[0016] Echinocystin, lot number: 510-30-5, when used, dissolve it in 2% DMSO, add a small amount of Tween 80 to help dissolve it, and dilute it to the required concentration. The test animals are male ICR mice, non-inbred closed group, body weight 25-30g, certificate number: Yidongzi 01-300l, provided by the Experimental Animal Center, School of Comparative Medicine, Yangzhou University, China. The room temperature in the laboratory is 20-22°C, the relative humidity is 40%-60%, the ventilator is ventilated, the natural light source is 12h / day, and the cages are kept with 8 animals per cage. The cages are cleaned once every three days.

[0017] In this experiment, the mouse left middle cerebral artery occlusion model (middle cerebral artery occlusion model, MCAO) was used according to the Longa method. The ICR mice were fasted for 6-8 hours before the operation, anesthetized with isoflurane...

Embodiment 2

[0028] Effect of Example 2 on the volume of cerebral ischemia-reperfusion injury in mice

[0029]Echinocystin, lot number: 510-30-5, when used, dissolve it in 2% DMSO, add a small amount of Tween 80 to help dissolve it, and dilute it to the required concentration. The test animals are male ICR mice, non-inbred closed group, body weight 25-30g, certificate number: Yidongzi 01-300l, provided by the Experimental Animal Center, School of Comparative Medicine, Yangzhou University, China. The room temperature in the laboratory is 20-22°C, the relative humidity is 40%-60%, the ventilator is ventilated, the natural light source is 12h / day, and the cages are kept with 8 animals per cage. The cages are cleaned once every three days.

[0030] In this experiment, the mouse left middle cerebral artery occlusion model (middle cerebral artery occlusion model, MCAO) model was used according to the Longa method. The mouse mask is connected to the mouth and nose. After about 30 seconds, the li...

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PUM

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Abstract

The present invention discloses an application of echinocystic acid in preparation of drugs for treating cerebral infarction and belongs to the pharmaceutical technical field. The echinocystic acid belongs to a small molecule triterpenoid compound, can reduce nerve tissue death after cerebral ischemia-reperfusion injury, reduces volume of the cerebral infarction after the cerebral ischemia-reperfusion injury, and reduces neurological function deficits. The echinocystic acid can be used as an active ingredient in a solvent, and pharmaceutically acceptable accessory materials or auxiliary ingredients can be added to prepare oral preparations or injections.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to the application of echinocytic acid in the preparation of medicine for treating cerebral infarction. Background technique [0002] Ischemic stroke is one of the main causes of disability and death for millions of people worldwide, with the characteristics of high morbidity, disability and mortality. Cerebral ischemia reperfusion (CIR) is the main reason for the aggravation of brain cell dysfunction and secondary damage after stroke. Its pathological mechanisms include oxygen free radical damage, calcium ion overload, mitochondrial damage, neurotoxic effects of excitatory amino acids, inflammatory damage, and blood-brain barrier disruption. Under the interaction of the above influencing factors, brain cell edema, nerve cell damage, even necrosis and apoptosis are finally caused. Currently, intravenous tissue plasminogen activator is considered to be the most effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P9/10A61P25/00
CPCA61K31/56A61P9/10A61P25/00
Inventor 于海龙陈蓓蕾陈应柱李晓波李军李威
Owner 于海龙
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