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Sustained release type tylosin phosphate microcapsule preparation and preparation method thereof

A tylosin phosphate, sustained-release technology, used in microcapsules, antibacterial drugs, capsule delivery, etc., can solve the problems of dose-dependent gastrointestinal disorders, smooth muscle stimulation, tylosin phosphate bitterness, etc. , to achieve the effect of improving drug bioavailability, less toxic and side effects, and improving drug stability

Inactive Publication Date: 2019-03-29
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] (1) Tylosin phosphate has a very bitter taste and poor palatability, which affects the feed intake of pigs;
[0008] (2) Dose-dependent gastrointestinal disorders (vomiting, diarrhea, intestinal pain, etc.) are prone to occur after oral administration of tylosin, which may be caused by stimulation of smooth muscle;
[0009] (3) Tylosin may also have certain liver toxicity; when administered in high doses, it is easy to cause cholestasis, vomiting or diarrhea

Method used

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  • Sustained release type tylosin phosphate microcapsule preparation and preparation method thereof
  • Sustained release type tylosin phosphate microcapsule preparation and preparation method thereof
  • Sustained release type tylosin phosphate microcapsule preparation and preparation method thereof

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preparation example Construction

[0039] A preparation method of sustained-release tylosin phosphate microcapsule preparation, comprising:

[0040] Mixing and melting step: put the excipients in the formula amount in an emulsification tank, heat and stir until the excipients are completely melted, then add tylosin phosphate into the melted excipients, and then carry out high-speed shearing and stirring to make all the tylosin phosphate Dissolve and form a uniform dispersion system with the auxiliary material melt to obtain a mixed melt;

[0041] Spray condensation granulation step: send the mixed molten liquid to a spray condensation granulation tower, centrifugal spray granulation, and obtain tylosin phosphate microcapsules.

[0042] In the whole process of the present invention, it is prepared by dissolving the tylosin phosphate crude drug in the heated auxiliary material molten liquid, and then preparing it through a spray condensation granulation system. The process can make the main drug uniformly disper...

Embodiment 1

[0051] A slow-release type tylosin phosphate microcapsule preparation, prepared according to the following method: Weigh 19.5kg stearyl alcohol, 2.4kg glyceryl monostearate, 1.5kg carnauba wax and emulsify in preheated to 100°C In the tank, continue heating, shearing and stirring (the shearing power is 15kW, and the stirring speed is 1500r / min) so that all the auxiliary materials are melted, and a yellow clear molten liquid is obtained. Under continuous heating at 100°C and shear stirring, 6.6 kg of tylosin phosphate was added, and heating and stirring was continued for 15 minutes to completely dissolve the tylosin phosphate. Before spray cooling and granulation, preheat the centrifugal nozzle for 30 minutes in advance, and turn on the cooling system to cool down in advance (inlet air temperature is 15°C, and outlet air temperature is 25°C). After the nozzle is preheated and the temperature of the cooling tower is lowered to the set value, the rotation speed of the nozzle is s...

Embodiment 2

[0053] A slow-release type tylosin phosphate microcapsule preparation is prepared according to the following method: Weigh 16.8kg stearyl alcohol, 3.0kg glyceryl monostearate, and 3.6kg carnauba wax in a preheated to 110°C In the emulsification tank, continuous heating, shearing and stirring (the shearing power is 20kW, and the stirring speed is 1800r / min) make all the auxiliary materials melt, and obtain a yellow clear molten liquid. Under continuous heating at 110°C and shearing and stirring, 6.6 kg of tylosin phosphate was added, and heating and stirring was continued for 10 minutes to completely dissolve the tylosin phosphate. Before spray cooling and granulation, preheat the centrifugal nozzle for 30 minutes in advance, and turn on the cooling system to cool down in advance (inlet air temperature is 18°C, and outlet air temperature is 28°C). After the nozzle is preheated and the temperature of the cooling tower is lowered to the set value, the rotation speed of the nozzle...

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Abstract

The invention discloses a sustained release type tylosin phosphate microcapsule preparation. The preparation comprises the following components in weight percentage: 2.2-22% of tylosin phosphate, and78-97.8% of excipients, wherein the sum of the weight percentages of the components is 100%. The sustained release type tylosin phosphate microcapsule preparation provided by the invention has the advantages of uniform distribution of the effective drug tylosin phosphate, round particles, good fluidity and dispersibility, and easy mixing with the feed; and effective drug components are isolated from the outside to achieve odor mask, moisture prevention, and improvement of drug stability and drug bioavailability. The invention also discloses a preparation method of the sustained release type tylosin phosphate microcapsule preparation; and the method has the advantages of simple process and high production efficiency, and can meet assembly line production.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to a slow-release tylosin phosphate microcapsule preparation and a preparation method thereof. Background technique [0002] Microcapsules refer to the use of natural or synthetic polymer materials as the capsule wall shell to wrap solid or liquid drugs to form microcapsules. Microencapsulation technology has broad development space in feed and veterinary medicine. As a new dosage form of veterinary drugs, microcapsules have a series of superior properties such as improving the palatability of drugs, improving drug stability, biocompatibility, endowing drug targeting, sustained release, and controlled release. Microencapsulation technology can significantly improve the absorption of fat-soluble drugs; ②The use of microencapsulation technology can avoid the degradation of drugs by gastric acid and the damage of drugs by the liver, and significantly improve the b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/7048A61P31/04
CPCA61K9/1617A61K31/7048A61P31/04
Inventor 梁劲康张桂君方炳虎廖陶雪温永茹吴志玲黎乃添梁惠莲
Owner GUANGDONG WENS DAHUANONG BIOTECH
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