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Antibacterial hydrogel material and preparation method and application thereof

A hydrogel and reactant technology, applied in medical science, bandages, etc., can solve the problems of material release, wound secondary infection, etc., and achieve broad application prospects, long production cycle, and good antibacterial effect

Active Publication Date: 2019-03-22
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of ionic liquids as antibacterial substances in the prior art has the problem of material release, which may cause secondary infection to the wound

Method used

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  • Antibacterial hydrogel material and preparation method and application thereof
  • Antibacterial hydrogel material and preparation method and application thereof
  • Antibacterial hydrogel material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Accurately weigh 1.494g of PVP, 1.5g of monoacrylamide, 0.012g of N,N-methylenebisacrylamide, 0.006g of azobisisobutyronitrile (AIBN), polyethylene glycol dimethacrylate (PEGDA) 0.08g, add 1.5mL deionized water, stir the used medicine evenly, blow nitrogen for 2min, put it in a thermostat at 70°C for 30min, and get the polymer-antibacterial film we need, which is recorded as the control gel.

Embodiment 2

[0052] Accurately weigh 1.62g of ionic liquid (1-vinyl-3-butylimidazolium bromide), 1.494g of PVP, 1.5g of monoacrylamide, 0.012g of N,N-methylenebisacrylamide, azobisisobutyl Nitrile (AIBN) 0.006g, polyethylene glycol bismethacrylate (PEGDA) 0.08g, add 1.5mL of deionized water, stir the used medicines evenly, pass nitrogen gas for 2min, put it into a thermostat at 70°C for 30min, Get the polymer-antibacterial film we need, named gel 1.

Embodiment 3

[0054] Accurately weigh 1.62g of ionic liquid (1-vinyl-3-butylimidazolium bromide), 2.241g of PVP, 1.5g of monoacrylamide, 0.012g of N,N-methylenebisacrylamide, azobisisobutyl Nitrile (AIBN) 0.006g, polyethylene glycol bismethacrylate (PEGDA) 0.08g, add 1.5mL deionized water, make the used medicines stir evenly, pass nitrogen gas for 2min, put into 70℃ incubator and react for 40min, get We need the polymer-antimicrobial film, named gel 2.

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Abstract

Disclosed are an antibacterial hydrogel material and a preparation method and application thereof. The antibacterial hydrogel material is prepared by reaction of ionic liquid, polyvinylpyrrolidone anda reactant. The antibacterial hydrogel material disclosed by the invention fully combines the characteristics that anions and cations of the ionic liquid can kill bacteria and the hydrogel, as a porous gel material, is conducive to water absorption and discharge. In application, the antibacterial hydrogel material can rapidly inhibit the growth of miscellaneous bacteria, shows a better bacteria inhibition effect than common antibiotics, provides wounds with an environment conducive to healing so as to reduce scars formed after healing of the wounds, and can also well absorb interstitial fluidaround the wounds, thereby facilitating healing and protection of the wounds. Besides, the preparation method is simple, and the cost is controllable. The antibacterial hydrogel material has wide application prospects.

Description

technical field [0001] The invention belongs to the field of antibacterial films and relates to a double-crosslinked antibacterial hydrogel material. Background technique [0002] Bacterial infection is a serious threat to human health. The widespread use of antibiotics has led to the emergence of drug-resistant bacteria. Traditional antibiotics have been difficult to cure infections caused by drug-resistant bacteria. Therefore, it is imminent to develop new antibacterial drugs or materials that are difficult to produce drug resistance. Antibacterial materials refer to a new class of functional materials that have the function of inhibiting or killing microorganisms. [0003] At present, the research on antibacterial materials mainly focuses on cationic compounds or polymers. Ionic liquids can be used as antibacterial materials because of their positive and negative ions. Ionic liquids can destroy the cell wall or cell membrane of the bacteria through electrostatic action...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F291/12C08F291/06A61L26/00
CPCA61L26/0014A61L26/0019A61L26/0066A61L26/008A61L26/0085A61L2300/202A61L2300/404C08F271/02C08F283/065C08L39/06
Inventor 李尧王康费旭田晶吴文忠徐龙权
Owner INNOBIO CORP LTD
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