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A low-cost method for preparing bone tissue scaffold material with high composite porosity

A support material and porosity technology, applied in the field of additive manufacturing, can solve the problems of single and incoherent pores, inaccurate control of channel size, high cost, etc., and achieve the effect of low price, good performance, and abundant raw materials

Active Publication Date: 2020-12-22
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the shortcomings of single and incoherent pores, inability to accurately control the pore size, and high cost of the three-dimensional porous bone repair materials prepared by traditional methods, the present invention provides a low-cost method for preparing bone tissue scaffold materials with high composite porosity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] (2) Preparation of slurry: Add 1-5wt.% organic monomer, 0.1-0.7wt.% cross-linking agent, 0.1-1.0wt.% dispersant into distilled water, heat to 60-80°C, and magnetically Stir for 5 to 30 minutes until the premix is ​​completely dissolved, then mix the mixed ceramic powder obtained in step (1) with the premix at a ratio of 35 to 65 vol%, and first stir with a high-speed machine (~15rpm / min) for 30 to 120 minutes , and then mechanically stir at a low speed (~10rpm / min) for 60~180min to obtain a ceramic printing slurry that is evenly mixed and has a viscosity of 50~300Pa.s. The organic monomer is one of acrylamide and methacrylamide; the crosslinking agent is methylenebisacrylamide, and the dispersant is oleic acid, ammonium citrate, polyethylene glycol, A type of polymethacrylamide. The gel system selected in the present invention does not chemically react with the pore-forming agent and the ceramic powder. The content and solid content of printing monomers affect the vis...

Embodiment 1

[0030] (1) Mix corn flour and calcium silicate powder at a mass ratio of 1:20, add 0.3wt.% dispersant and 40wt.% deionized water, mix on a ball mill for 0.5-2 hours, and the ball-to-material ratio is 1 : 2. After mixing, dry in a vacuum oven at 30°C for 120 minutes;

[0031] (2) Add 1wt.% acrylamide, 0.5wt.% methylenebisacrylamide, and 0.3wt.% ammonium citrate into distilled water, heat to 70°C, and stir magnetically for 10 minutes until the premix is ​​completely dissolved. Then mix the mixed ceramic powder obtained in step (1) with the premixed liquid in a ratio of 40vol%, and first stir with high-speed machinery (~15rpm / min) for 60min, and then stir with low-speed machinery (~10rpm / min) for 60min to obtain a uniform mixture. , a ceramic printing slurry with a viscosity of 200Pa.s;

[0032] (3) Use 3D modeling software to draw a model with visible pores, then import the 3D model into the computer's control system to generate G-code, and put the ceramic slurry obtained in st...

Embodiment 2

[0035] (1) Mix sweet potato powder and calcium phosphate powder at a mass ratio of 1:25, add 0.25wt.% dispersant and 38wt.% deionized water, mix on a ball mill for 1 hour, the ball-to-material ratio is 1:1.5, After mixing, dry in a vacuum oven at 40°C for 90 minutes;

[0036] (2) Add 2wt.% acrylamide, 0.6wt.% methylenebisacrylamide, and 0.5wt.% ammonium citrate into distilled water, heat to 50°C, and magnetically stir for 10 minutes until the premix is ​​completely dissolved. Then mix the mixed ceramic powder obtained in step (1) with the pre-mixed liquid in a ratio of 40vol%, first stir with high-speed machinery (~15rpm / min) for 30min, and then stir with low-speed machinery (~10rpm / min) for 120min to obtain a uniform mixture , a ceramic printing slurry with a viscosity of 250Pa.s;

[0037] (3) Use 3D modeling software to draw a model with visible pores, then import the 3D model into the computer's control system to generate G-code, and put the ceramic slurry obtained in step...

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Abstract

The invention provides a method for preparing a high-porosity bone tissue scaffold composite by 3D printing, and belongs to the field of additive manufacturing (3D printing). The method provided by the invention is based on a 3D gel technology and a pore former method. The method comprises the steps that firstly, a low-cost pore former and ceramic powder are uniformly mixed to prepare low-viscosity and high-solid-content slurry suitable for printing in combination with a gel system, and a blank body with macroscopically-visible pores is prepared with 3D gel printing; then the blank body is dried, degreased and sintered; and the pore former is decomposed and oxidized to be discharged into air to form microscopic pores, so that the high-porosity bone scaffold composite is obtained finally. The method provided by the invention can precisely control the size, shape and distribution of the macroscopic pores, realizes the preparation of the high-porosity bone tissue scaffold composite with low cost, and has a simple process and low cost.

Description

technical field [0001] The invention relates to a method for preparing a bone tissue scaffold material with high composite porosity by 3D printing, and belongs to the field of additive manufacturing (3D printing). Background technique [0002] 3D printing, also known as additive manufacturing (AM), completes printing by adding material layer by layer, which greatly reduces the waste of raw materials and enables near-net shaping of complex shapes. Therefore, 3D printing has attracted extensive attention from researchers. 3D printing mainly involves building a model using 3D software, importing the model into slicing software, and printing the model using a 3D printer. 3D printing technologies are mainly divided into the following categories: selective laser sintering (SLS), selective laser melting (SLM), fused deposition modeling (FDM), [17], stereolithography (SLA), 3D printing (3DP) and Direct Inkjet Printing (DIP). 3D gel printing technology is a new type of printing te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/10C08F220/56C08F222/38B33Y10/00
CPCA61L27/10A61L27/56A61L2430/02B33Y10/00C08F220/56C08F222/385
Inventor 邵慧萍张志男林涛张雨梦王鲁辉
Owner UNIV OF SCI & TECH BEIJING
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