Joint lubricant and preparation method thereof

A lubricant and bone joint technology, applied in the field of bone joint lubricant and its preparation, can solve the problems of unsatisfactory treatment effect and limited joint lubrication effect, and achieve good shear dilution, good support effect, and strong lubrication effect Effect

Active Publication Date: 2019-03-19
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sodium hyaluronate is currently a common choice for the treatment of early osteoarthritis, but because it will be quickly degraded by hyaluronidase in the body, the lubricating effect on joints is limited, and the therapeutic effect is not ideal

Method used

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  • Joint lubricant and preparation method thereof
  • Joint lubricant and preparation method thereof
  • Joint lubricant and preparation method thereof

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experiment example 1

[0026] Experimental example 1 The preparation method of bone joint lubricant of the present invention

[0027] Using 2-methacryloyloxyethylphosphorylcholine (MPC) as amphoteric monomer, methylenebisacrylamide (MBA) as crosslinking agent, ammonium peroxodisulfate (APS) as polymerization initiator, tetramethyl ethylenediamine (TMEDA) as the catalyst. The synthesis of microgels is carried out in the aqueous phase of water-in-oil emulsions, as figure 1 shown.

[0028] Dissolve 16.4 mg of amphoteric monomer and 7.7 mg of cross-linking agent in 5 mL of deionized water to form an aqueous phase; dissolve 0.2 mL of Tween 80 and 0.2 mL of Span 80 in 10 mL of hexane to form an oil phase. Mix the water phase and the oil phase in a 100mL flask, stir vigorously for 5min, and sonicate for 30min to form a microemulsion. Purify the flask with argon at room temperature to degas the solution, then add 0.06 mL of APS with a concentration of 0.22 mol / L and 0.02 mL of TMEDA, respectively. The o...

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Abstract

The invention provides a joint lubricant. The joint lubricant is gel prepared from the following components in parts by weight: 13-20 parts of 2-methacryloyloxyethyl phosphorylcholine, 6-10 parts of methylene bisacrylamide, 170-256 parts of Tween 80, 159-239 parts of Span 80, 2.4-3.7 parts of ammonium peroxydisulfate, 12-19 parts of tetramethylethylenediamine, 4000-6000 parts of deionized water and 5248-7858 parts of hexane. The joint lubricant has excellent shearing thinning performance, has relatively high viscosity under an unstressed effect, and has the viscosity reduced along with increase of the shearing rate under a stressed effect. Hereby, the gel perhaps has excellent supporting effect when a patient stands still, but relatively low viscosity when the patient walks to reduce friction, and thus has durable and strong lubricating effect. The injection microgel prepared by the method can be used as a new choice for intervention of patients with early osteoarthritis.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a bone joint lubricant and a preparation method thereof. Background technique [0002] Osteoarthritis is a common clinical disease in orthopedics, and the knee joint is one of the most frequently involved parts. Since the knee is the body's main weight-bearing joint, osteoarthritis of the knee can lead to severe functional impairment in patients. Sodium hyaluronate is currently a common choice for the treatment of early osteoarthritis, but because it will be quickly degraded by hyaluronidase in the body, its lubricating effect on joints is limited, and the therapeutic effect is not ideal. [0003] Therefore, it is of great significance to study a new joint lubricant with good lubricating effect, good biocompatibility and not easy to degrade for the treatment of osteoarthritis. Contents of the invention [0004] The object of the present invention is to provide a bone joint...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14A61L31/16C08F230/02C08F222/38
CPCA61L31/048A61L31/06A61L31/145A61L31/16A61L2300/452A61L2400/06C08F230/02C08L71/02C08L43/02C08F222/385
Inventor 李军刘雷黄泽宇张正东
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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