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Application of paeoniflorin-6-O'-benzenesulfonate

A technology of -6-O and besylate, applied in the field of known compounds, can solve the problem of low oral bioavailability, achieve the effect of maintaining and repairing kidney function and improving kidney damage

Inactive Publication Date: 2019-03-19
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Paeoniflorin is one of the main active monomer components of Radix Paeoniae Alba, which has certain anti-inflammatory and immunomodulatory activities, but its water solubility is extremely strong, and its oral bioavailability is extremely low, about 3-4% [11-12]

Method used

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  • Application of paeoniflorin-6-O'-benzenesulfonate

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Example 1: Protective effect of CP-25 on methotrexate-induced acute kidney injury in rats

[0044] 1. Experimental method

[0045] 1.1 Animal grouping, modeling and administration

[0046] Clean grade Sprague-Dawley rats (2 months old, male, body weight 180g-200g), 30 in total. Rats were randomly divided into 5 groups: normal group, model group, CP-25 prevention group (50mg / kg / day), CP-25 treatment group (50mg / kg / day), resveratrol group (20mg / kg / day) day). Rats were given a single intraperitoneal injection of methotrexate (20 mg / kg -1 ) induced acute kidney injury. The CP-25 prevention group started administration 5 days before modeling, and the treatment group started administration on the second day after modeling respectively, and continued administration for 5 days. The normal group and the model group were given the same amount of vehicle. On the 6th day after modeling, the 24-hour urine of the rats was collected through metabolic cages, and 0.5ml of plasma w...

Embodiment 2

[0066] Example 2: The protective effect of CP-25 on cisplatin-induced acute kidney injury in rats

[0067] 1. Experimental method

[0068] 1.1 Animal grouping, modeling and administration

[0069] Clean grade Sprague-Dawley rats (2 months old, male, body weight 180g-200g), a total of 24, were randomly divided into 4 groups: normal group, model group, CP-25 prevention group (50mg / kg / day), CP -25 treatment groups (50 mg / kg / day). Rats were given a single intraperitoneal injection of cisplatin (10 mg / kg -1 ) induced acute kidney injury model. The CP-25 prevention group started administration 5 days before modeling, and the treatment group started administration on the second day after modeling respectively, and continued administration for 5 days. The normal group and the model group were given the same amount of vehicle. After the last administration, the urine of the rats was collected for 24 hours through the metabolic cage, and 0.5ml of plasma was collected from the fundu...

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Abstract

The invention discloses application of paeoniflorin-6-O'-benzenesulfonate. The application refers to application in preparation of preparations for preventing and / or treating renal injuries induced byantitumor drugs. The antitumor drugs comprise alkylating agents, anti-metabolites, antibiotics or metal platinum antitumor drugs. Researches prove that the paeoniflorin-6-O'-benzenesulfonate disclosed by the invention has an effect of protecting the renal injuries induced by antitumor drugs, is capable of improving renal injuries and maintaining and restoring renal functions, and is safe and effective.

Description

technical field [0001] The present invention relates to the use of a known compound, specifically a use of paeoniflorin-6-O'-benzenesulfonate. Background technique [0002] Drug-induced nephropathy is a kind of disease of various kidney damages caused by drugs within the normal usage and dosage, and it is also one of the common clinical drug complications. , Chronic renal failure. Epidemiological studies have found that acute renal failure caused by drug-induced renal injury accounts for about 5%-20%, and is one of the important causes of drug-induced death [1]. Different types and doses of drugs cause varying degrees of damage to the kidneys. Antineoplastic drugs are common drugs for inducing acute kidney injury. Nephrotoxicity is mostly dose-dependent or aggravated after combined medication, and the clinical manifestations vary in severity and duration, and some can even be delayed for several years after drug withdrawal . Common antineoplastic drugs with kidney damage...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P13/12
CPCA61K31/7048A61P13/12
Inventor 魏伟王春
Owner ANHUI MEDICAL UNIV
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