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Resveratrol microsphere and preparation method thereof

A technology of resveratrol and microspheres, which can be used in cardiovascular system diseases, non-active ingredients of polymer compounds, non-central analgesics, etc., and can solve problems such as the stability of nano-liposomes

Inactive Publication Date: 2019-02-22
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But again, nanoliposomes also have stability problems during storage

Method used

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  • Resveratrol microsphere and preparation method thereof
  • Resveratrol microsphere and preparation method thereof
  • Resveratrol microsphere and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A resveratrol microsphere is prepared from the following raw materials in parts by weight: 1 part of bovine serum albumin, 0.2 part of resveratrol, 60 parts of vegetable oil, 2 parts of emulsifier and 10 parts of distilled water.

[0031] The vegetable oil is castor oil.

[0032] The emulsifier is Span 80.

[0033] A preparation method of resveratrol microspheres, comprising the following steps:

[0034] (1) dissolving bovine serum albumin in distilled water according to the proportioning ratio, stirring evenly to obtain bovine serum albumin solution for subsequent use;

[0035] (2) adding the resveratrol of proportioning amount to the bovine serum albumin solution obtained in step (1), stirring evenly to make a mixed solution;

[0036] (3) Weigh half of the vegetable oil for stirring, use a syringe to absorb the mixed solution obtained in step (2), add it dropwise to the vegetable oil under stirring, add vegetable oil and stir together for 10-20min, and perform ultra...

Embodiment 2

[0044] A resveratrol microsphere is prepared from the following raw materials in parts by weight: 1.8 parts of bovine serum albumin, 0.2 parts of resveratrol, 60 parts of vegetable oil, 2.4 parts of emulsifier and 15 parts of distilled water.

[0045] The vegetable oil is corn oil.

[0046] The emulsifier is Tween 80.

[0047] A preparation method of resveratrol microspheres, comprising the following steps:

[0048] (1) dissolving bovine serum albumin in distilled water according to the proportioning ratio, stirring evenly to obtain bovine serum albumin solution for subsequent use;

[0049] (2) adding the resveratrol of proportioning amount to the bovine serum albumin solution obtained in step (1), stirring evenly to make a mixed solution;

[0050] (3) Weigh half of the vegetable oil for stirring, use a syringe to absorb the mixed solution obtained in step (2), add it dropwise to the vegetable oil under stirring, add vegetable oil and stir together for 10-20min, and perform ul...

Embodiment 3

[0058] A resveratrol microsphere is prepared from the following raw materials in parts by weight: 4.5 parts of bovine serum albumin, 1 part of resveratrol, 200 parts of vegetable oil, 10 parts of emulsifier and 30 parts of distilled water.

[0059] Described vegetable oil is olive oil.

[0060] The emulsifier is Tween 60.

[0061] A preparation method of resveratrol microspheres, comprising the following steps:

[0062] (1) dissolving bovine serum albumin in distilled water according to the proportioning ratio, stirring evenly to obtain bovine serum albumin solution for subsequent use;

[0063] (2) adding the resveratrol of proportioning amount to the bovine serum albumin solution obtained in step (1), stirring evenly to make a mixed solution;

[0064] (3) Weigh half of the vegetable oil for stirring, use a syringe to absorb the mixed solution obtained in step (2), add it dropwise to the vegetable oil under stirring, add vegetable oil and stir together for 10-20min, and perf...

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Abstract

The invention discloses a resveratrol microsphere and a preparation method thereof, and belongs to the technical field of organic micro-nano materials. The resveratrol microsphere and the preparationmethod thereof aim to solve the problem that resveratrol has less solubility in water, poor light stability, poor oral absorption, low bioavailability, and difficulty in long-lasting action. The resveratrol microsphere is prepared with bovine serum albumin, resveratrol, vegetable oil, an emulsifier and distilled water as raw materials, the encapsulation rate of the obtained microsphere is up to 78%, and the drug loading amount of the microsphere is up to 81%. After 10 hours of UV irradiation treatment, the retention rate of pure resveratrol is only about 20% while the retention rate of resveratrol in protein microspheres is 50% or above, and the photostability is improved. Meanwhile, the preparation process is simple, easy to implement, and suitable for being applied and popularized.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a resveratrol microsphere and a preparation method thereof. Background technique [0002] The chemical name of resveratrol is (E)-3,5,4-trihydroxystilbene, and it can also be called polydagenin, stilbene triol, etc. Generally speaking, resveratrol is a polyphenolic compound, mainly derived from plants such as peanuts, mulberries, knotweeds, and grapes. The chemical formula is C 14 h 12 o 3 , molecular weight 228.25, is a non-flavonoid polyphenol compound. Resveratrol is a colorless needle-like crystal, easily soluble in ether, chloroform, methanol, ethanol, acetone and other organic solvents, but the chemical stability of resveratrol is very low, difficult to dissolve in water, and easy to decompose when exposed to light. [0003] Resveratrol exists in a large amount in some foods that people often eat, such as grapes and peanuts. Later, peopl...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/42A61K31/05A61P29/00A61P31/04A61P31/10A61P35/00A61P39/06A61P9/00
CPCA61K9/1658A61K31/05A61P9/00A61P29/00A61P31/04A61P31/10A61P35/00A61P39/06
Inventor 高振珅刘聪王振刘凤志李海刚陈敏
Owner LINYI UNIVERSITY
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