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Preparation method and application of ceramide promoter

A technology of ceramide and accelerator, which is applied in the field of preparation of ceramide accelerator, can solve the problems of undisclosed Chinese herbal medicine pretreatment, drying, pulverization process, low extraction efficiency of active ingredients, difficult transdermal absorption, etc., to improve biological Utilization, small difference in volume, effect of promoting ceramide production

Inactive Publication Date: 2019-02-05
派能生物科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned disclosed ceramide accelerator or its preparation method has the following problems: 1. Most of the ceramide substances are water-insoluble substances, while the prior art uses Chinese medicine water extraction components or petroleum ether extraction components, and the polarity is too large or too small. It is not easy to promote transdermal absorption; 2. The preparation process adopts simple low-temperature extraction, filtration, and concentration, and the pretreatment, drying, and crushing processes of Chinese herbal medicines are not disclosed. Although the process is simple, the extraction efficiency of active ingredients is low, which increases the amount of raw materials. cost

Method used

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  • Preparation method and application of ceramide promoter
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  • Preparation method and application of ceramide promoter

Examples

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Effect test

Embodiment 1

[0036] A preparation method of a ceramide promoter, comprising the following steps:

[0037] 1) Raw material selection and pretreatment: in parts by weight, weigh 106 parts of pineapple leaves, 16 parts of white peony root, 23 parts of motherwort, and 8 parts of oolong tea; wherein, the pineapple leaves are selected from immature teas that grow for more than two months a year. Pineapple, after pretreatment, let it stand and drain; white peony root, motherwort, and oolong tea are washed with water, and dried for later use; among them, the pretreatment of pineapple leaves is as follows: cut into 1-3cm long strips, and use 6wt% carbonic acid Soak in sodium solution for 25 minutes, take it out and put it into an ultrasonic cleaner filled with purified water for 7 minutes of ultrasonic treatment.

[0038] 2) Short-term heat treatment: send the pretreated pineapple leaves, white peony root, motherwort, and oolong tea into a steam rotary dryer, pass in hot steam at 62°C for 4 minutes...

Embodiment 2

[0044] A preparation method of a ceramide promoter, comprising the following steps:

[0045] 1) Raw material selection and pretreatment: In parts by weight, weigh 96 parts of pineapple leaves, 15 parts of Radix Paeoniae Alba, 26 parts of motherwort, and 9 parts of oolong tea; wherein, the pineapple leaves are selected from immature teas that grow for more than two months a year. Pineapple, after pretreatment, let it stand and drain; white peony root, motherwort, and oolong tea are washed with water, and dried for later use; among them, the pretreatment of pineapple leaves is as follows: cut into 1-3cm long strips, and use 8wt% carbonic acid Soak in sodium solution for 22 minutes, take it out and put it into an ultrasonic cleaner filled with purified water for ultrasonic treatment for 6 minutes.

[0046] 2) Short-term heat treatment: send the pretreated pineapple leaves, white peony root, motherwort, and oolong tea into a steam rotary dryer, pass in hot steam at 60±5°C for 3-5 ...

Embodiment 3

[0052] A preparation method of a ceramide promoter, comprising the following steps:

[0053] 1) Raw material selection and pretreatment: in parts by weight, weigh 115 parts of pineapple leaves, 18 parts of white peony root, 27 parts of motherwort, and 10 parts of oolong tea; wherein, the pineapple leaves are selected from immature teas that grow for more than two months a year. Pineapple, after pretreatment, let it stand and drain; white peony root, motherwort, and oolong tea are washed with water, and dried for later use; among them, the pretreatment of pineapple leaves is as follows: cut into 1-3cm long strips, and use 6wt% carbonic acid Soak in sodium solution for 30 minutes, take it out and put it into an ultrasonic cleaner filled with purified water for 8 minutes of ultrasonic treatment.

[0054] 2) Short-term heat treatment: send the pretreated pineapple leaves, white peony root, motherwort, and oolong tea into a steam rotary dryer, pass in hot steam at 65°C for 3 minute...

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Abstract

The invention discloses a preparation method and application of a ceramide promoter, and relates to the technical field of preparation and application of biological active substances. The ceramide promoter selects pineapple leaves, radix paeoniae alba, motherwort herb and oolong tea leaves as raw materials, azone, menthol and fructus litseae oil as auxiliary materials, and a technological path ofraw material selection and pretreatment, short-time heat treatment, freeze-drying, pulverization, extraction and concentration, filter residue re-extraction, and addition of the auxiliary materials isscientifically and rationally designed; the ceramide promoter has high transdermal absorption, the extraction rate of active ingredients in the raw materials is high, and raw material costs are reduced; experiments prove that the ceramide promoter has a good promotion effect on ceramide production, facial wrinkles can be significantly relieved, and the facial moisturizing and shielding functionscan be enhanced.

Description

technical field [0001] The invention relates to the technical field of preparation and application of bioactive substances, in particular to a preparation method and application of a ceramide accelerator. Background technique [0002] Ceramide is a lipid that exists in a small amount in the whole body, but it accounts for more than half of the lipids in the stratum corneum, the outermost layer of the skin, and plays an important role in the skin's moisturizing mechanism and barrier mechanism. In addition, in recent years, the induction of cell apoptosis, differentiation induction, and proliferation inhibition by promoting the production of ceramide have also been reported, and the therapeutic effect on cell proliferation and differentiation diseases caused by inflammatory diseases, malignant tumors, etc. remains to be further studied. Studies have also reported that ceramides have inhibitory effects on bone resorption, bone strengthening, and alveolar reduction, and can prev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/34A61K8/49A61K8/92A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/34A61K8/4906A61K8/922A61K2800/84A61Q19/00A61Q19/08
Inventor 盘锐伦
Owner 派能生物科技(深圳)有限公司
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