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Spherical famciclovir sustained-release capsule preparation method

A famciclovir and sustained-release capsule technology, which is applied in the field of preparation of spherical famciclovir sustained-release capsules, can solve the problems of fragmentation, insufficient viscosity, and increased viscosity, and achieves the effects of increasing viscosity, delaying release speed, and reducing the number of times of medication

Inactive Publication Date: 2019-02-01
安徽鼎旺医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the present invention, due to the weak hydrogen bond connecting the microcrystalline regions, the ordinary corn starch swells when heated, finally splits and breaks, and the viscosity decreases. The cross-linking modification of the ordinary corn starch makes the formation of chemical bridges between the starches In addition, the modified starch has a larger specific surface area and can absorb more pharmaceutically active components per unit mass, which solves the problem of The drug carrier starch is not viscous enough, and the drug is less adsorbed per unit mass, which cannot maximize the effect of the drug

Method used

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  • Spherical famciclovir sustained-release capsule preparation method

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Embodiment 1

[0033] A preparation method of spherical famciclovir sustained-release capsules, the preparation method comprising the steps of:

[0034] (1) Preparation of spherical pellets: Add 30g famciclovir, 20g modified starch and 10g sucrose to a beaker filled with 20g deionized water successively, mix and stir evenly, add 5g binder until the solution is gelatinous, put Take it out after 15 to 25 hours in the refrigerator, and make spherical pills by extrusion and spheronization; the spherical pills in the present invention are the active ingredients of the medicine, which enter the human body and release the drug effect rapidly under the action of gastric acid. The coating layer is attached to release the drug effect slowly, which also makes the drug effect work for a longer time;

[0035](2) Preparation of coating layer: Add 30g of enteric polymer, 5g of polyethylene glycol, 5g of anti-sticking agent, and 10g of magnesium stearate into a beaker containing 20g of absolute ethanol in s...

Embodiment 2

[0038] A preparation method of spherical famciclovir sustained-release capsules, the preparation method comprising the steps of:

[0039] (1) Preparation of spherical pellets: Add 40g famciclovir, 30g modified starch and 20g sucrose to a beaker filled with 30g deionized water successively, mix and stir evenly, add 10g binder until the solution is gelatinous, put Take it out after 15 to 25 hours in the refrigerator, and make spherical pills by extrusion and spheronization; the spherical pills in the present invention are the active ingredients of the medicine, which enter the human body and release the drug effect rapidly under the action of gastric acid. The coating layer is attached to release the drug effect slowly, which also makes the drug effect work for a longer time;

[0040] (2) Preparation of coating layer: Add 40g of enteric polymer, 10g of polyethylene glycol, 10g of anti-sticking agent, and 20g of magnesium stearate into a beaker containing 30g of absolute ethanol ...

Embodiment 3

[0043] A preparation method of spherical famciclovir sustained-release capsules, the preparation method comprising the steps of:

[0044] (1) Preparation of spherical pellets: Add 40g of famciclovir, 30g of common cornstarch and 20g of sucrose to a beaker containing 30g of deionized water in turn, mix and stir evenly, add 10g of binder until the solution is gelatinous, and put Take it out after 15 to 25 hours in the refrigerator, and make spherical pills by extrusion and spheronization; the spherical pills in the present invention are the active ingredients of the medicine, which enter the human body and release the drug effect rapidly under the action of gastric acid. The coating layer is attached to release the drug effect slowly, which also makes the drug effect work for a longer time;

[0045] (2) Preparation of coating layer: Add 40g of enteric polymer, 10g of polyethylene glycol, 10g of anti-sticking agent, and 20g of magnesium stearate into a beaker containing 30g of ab...

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Abstract

The invention discloses a spherical famciclovir sustained-release capsule preparation method, which comprises: preparation of spherical pellet, preparation of coating layer, and preparation of spherical famciclovir sustained-release capsule. According to the present invention, with the prepared modified starch, the disadvantages that the ordinary corn starch does not have sufficient viscosity, adsorbs the less drug at the unit mass, and cannot achieve the maximized efficacy can be solved; and the spherical famciclovir sustained-release capsule can quickly pass through the intestinal tract, wherein mainly the coating layer is the material formed by the enteric polymer soluble in the intestinal tract, and can slow down the resistance between the drug and the intestinal tract so as to make the drug quickly enter the stomach to provide the treatment effect, the coating layer is slowly dissolved under the action of gastric acid after the drug enters the stomach, and the efficacy of the spherical pellet is slowly released, such that the drug release can be delayed in the human body, and the efficacy can be provided for a long time so as to reduce the drug taking frequency of the patient.

Description

technical field [0001] The invention belongs to the field of pharmacy, and mainly relates to a preparation method of spherical famciclovir sustained-release capsules. Background technique [0002] Famciclovir was synthesized in 1985 and has inhibitory effects on herpes simplex virus, herpes zoster virus and hepatitis B virus. It is clinically used to treat herpes zoster, facial herpes and genital herpes. The role of hepatitis is also increasingly valued by people. [0003] Famciclovir is the prodrug of penciclovir, which is rapidly absorbed after oral administration, removes two acetyl groups through relevant enzymes in the intestinal wall and liver, and oxidizes the 6-position on the purine ring into a ketone group, which is converted into penciclovir Wei. In HSV-I and HSV-II infected cells, penciclovir is first monophosphorylated by the virus-specific thymidine kinase to form penciclovir monophosphate, which is further catalyzed by host enzymes to generate diphosphorylat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/32A61K9/22A61K47/36A61K31/52A61P31/22A61P17/00A61P15/00A61P1/16A61P31/20C08B31/00
CPCA61P1/16A61P15/00A61P17/00A61P31/20A61P31/22A61K9/2059A61K9/2846A61K31/52C08B31/003
Inventor 杨会来方泽民
Owner 安徽鼎旺医药有限公司
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