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Ambrisentan tablet composition

A technology of Sentan tablets and Ambrisentan, which is applied in the field of Ambrisentan tablet compositions to achieve the effect of solving the problem of content uniformity

Inactive Publication Date: 2019-01-29
WEIHAI GUANBIAO INFORMATION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time solve the problem of dissolution stability during storage

Method used

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  • Ambrisentan tablet composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, Ambrisentan 10g, lactose 50g, calcium hydrogen phosphate 12g, micropowder silica gel 28g, microcrystalline cellulose 50g, croscarmellose sodium 4g, magnesium stearate 1.6g, according to the technical scheme of this manual 1000 tablets were prepared according to the preparation method described above.

Embodiment 2

[0018] Embodiment 2, Ambrisentan 5g, lactose 32g, calcium hydrogen phosphate 6g, micropowder silica gel 16g, microcrystalline cellulose 28g, croscarmellose sodium 1.5g, magnesium stearate 0.8g, according to the technical scheme of this manual The preparation method prepares 1000 tablets.

Embodiment 3

[0019] Embodiment 3. Ambrisentan 10g, lactose 40g, calcium hydrogen phosphate 9g, micropowder silica gel 20g, microcrystalline cellulose 39g, croscarmellose sodium 3g, magnesium stearate 1.2g. Prepare 1000 tablets according to the preparation method described in the technical scheme of this specification.

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PUM

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Abstract

The invention relates to an Ambrisentan tablet composition, and belongs to the technical field of pharmacy. Per thousand tablets of Ambrisentan tablet composition comprise 5 to 10g of Ambrisentan, 32to 50g of lactose, 6 to 12g of calcium hydrophosphate, 16 to 28g of superfine silica gel powder, 28 to 50g of microcrystalline cellulose, 1.5 to 4g of croscarmellose sodium and 0.8 to 1.6g of magnesium stearate. The invention provides the qualified Ambrisentan tablet composition; and the problems of low dissolution rate and low content uniformity of the tablet in the preparation process are solved.

Description

technical field [0001] The invention relates to an ambrisentan tablet composition, which belongs to the technical field of pharmacy. Background technique [0002] Pulmonary arterial hypertension (PAH) is a rare disease that is very unfamiliar to the general public but extremely malignant. About 15 to 25 people in every million people will suffer from this disease. It can occur in any age and gender, usually more than 70% of the patients are young, and the incidence rate of women is about 2 times higher than that of men. The onset of the disease is insidious and the development is relatively slow. The patient's earliest symptoms are usually shortness of breath, fatigue, and palpitations during physical activity. As the disease progresses, patients may even experience chest pain, cough, hemoptysis, and syncope. If the correct diagnosis and targeted treatment cannot be obtained in time, most patients will die within 2 to 3 years or even less. Therefore, PAH is called "malig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/505A61K47/38A61K47/26A61K47/12A61K47/04A61K47/02A61P11/00A61P9/12
CPCA61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K31/505A61P9/12A61P11/00
Inventor 不公告发明人
Owner WEIHAI GUANBIAO INFORMATION TECH
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