A kind of flupentixol melitracen pharmaceutical composition and preparation method thereof
A technology for flupentixol and melitracen tablets, applied in the field of pharmaceutical preparations, can solve problems such as poor fluidity and compressibility, and achieve the effects of avoiding a moist-heat drying process, and having good production process reproducibility and stability.
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Embodiment 1
[0047] Example 1 Preparation of flupentixol melitracen pharmaceutical composition
[0048] prescription:
[0049]
[0050] The preparation method is prepared according to the following steps:
[0051] (1), flupentixol hydrochloride and hydroxypropyl cellulose were mixed in equal amounts three times, and passed through an 80-mesh sieve to obtain the mixture ①;
[0052] (2), the mixture ① and melitracen hydrochloride were mixed twice in equal amounts, and passed through an 80-mesh sieve to obtain the mixture ②;
[0053] (3), mix the mixture ② with microcrystalline cellulose PH12 in an equal amount, and pass through a 40-mesh sieve to obtain the mixture ③;
[0054] (4), put the mixture ③, spray-dried lactose, and the remaining microcrystalline cellulose PH12 into a multi-directional motion mixer, pre-mix for about 15 minutes at 10 rpm, then add stearic acid and silicon dioxide and mix for about 10 minutes, Get the mixture ④;
[0055] (5), the mixture ④ is directly compress...
Embodiment 2
[0057] Example 2 Preparation of flupentixol melitracen pharmaceutical composition
[0058] prescription:
[0059]
[0060] The preparation method is prepared according to the following steps:
[0061] (1), flupenthixol hydrochloride and carboxymethyl starch sodium are carried out three equal volumes of incremental mixing, cross 80 mesh sieves, and obtain the mixture ①;
[0062] (2), the mixture ① and melitracen hydrochloride were mixed twice in equal amounts, and passed through an 80-mesh sieve to obtain the mixture ②;
[0063] (3), mix the mixture ② with microcrystalline cellulose PH12 in an equal amount, and pass through a 40-mesh sieve to obtain the mixture ③;
[0064] (4), put the mixture ③, mannitol, and remaining microcrystalline cellulose PH12 into a multi-directional motion mixer, pre-mix for about 15 minutes at 10 rpm, then add magnesium stearate and talcum powder and mix for about 10 minutes to obtain Mixture ④;
[0065] (5), the mixture ④ is directly compress...
Embodiment 3
[0067] Example 3 Preparation of flupentixol melitracen pharmaceutical composition
[0068] prescription:
[0069]
[0070]
[0071] The preparation method is prepared according to the following steps:
[0072] (1), flupenthixol hydrochloride and cross-linked polyvinylpyrrolidone are mixed three times in equal amounts, and passed through an 80-mesh sieve to obtain the mixture ①;
[0073] (2), the mixture ① and melitracen hydrochloride were mixed twice in equal amounts, and passed through an 80-mesh sieve to obtain the mixture ②;
[0074] (3), mix the mixture ② with microcrystalline cellulose PH102 in an equal amount, and pass through a 40-mesh sieve to obtain the mixture ③;
[0075] (4) Put the mixture ③, pregelatinized starch, and remaining microcrystalline cellulose PH102 into a multi-directional motion mixer, pre-mix for about 15 minutes at 10 rpm, then add stearic acid and sodium stearyl fumarate to mix About 10 minutes, the mixture ④ was obtained;
[0076] (5), t...
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