Fenofibrate tablet composition and preparation method thereof
A technology of fenofibrate and composition, applied in the field of fenofibrate tablet composition, to meet the requirements of dissolution consistency evaluation, reduce adverse reactions, and overcome abdominal discomfort
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Embodiment 1
[0021] Embodiment 1. 2g of fenofibrate with a particle size of 6 microns, 72g of food-grade chitosan oligosaccharide, 100g of microcrystalline cellulose, 40g of hypromellose E5, 32g of polysorbate-80, 12g of micronized silica gel, stearic acid Magnesium 2g. Prepared according to the preparation method described in the technical scheme of the manual, spray granulation using 30% ethanol aqueous solution, and prepare 2000 tablets.
Embodiment 2
[0022] Example 2. Fenofibrate 2g with a particle size of 10 microns, food-grade chitosan oligosaccharide 120g, microcrystalline cellulose 60g, hydroxypropyl cellulose E5 60g, polysorbate-80 16g, micronized silica gel 24g, stearic acid Magnesium 4g. According to the preparation method described in the technical scheme of the manual, spray granulation uses 45% ethanol aqueous solution to prepare 2000 tablets.
Embodiment 3
[0023] Example 3. Fenofibrate 2g with a particle size of 8.5 microns, food-grade chitosan oligosaccharide 100g, microcrystalline cellulose 84g, hydroxypropyl cellulose E5 52g, polysorbate-80 28g, micronized silica gel 18g, stearic acid Magnesium 3g. According to the preparation method described in the technical scheme of the manual, spray 35% ethanol aqueous solution to granulate, and prepare 2000 tablets.
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