Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Binder-type hydrogel, and preparation method and application thereof

A hydrogel and adhesive technology, which is used in drug combinations, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of loss, insufficient mechanical strength of hydrogels, etc., and achieve tight force and improve viscosity. , good biocompatibility

Active Publication Date: 2019-01-25
朱飞燕
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the contradiction between the viscosity and the optimization of mechanical properties of the scaffold material hydrogel of the current cartilage tissue engineering, and solve the problem that the mechanical strength of the hydrogel is not enough in the application process of cartilage tissue engineering, and it is easy to lose from the tissue. Provide a kind of adhesive type hydrogel and its preparation method and application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0021] Specific embodiment one: In this embodiment, the adhesive type hydrogel is compounded (introduced) on the surface of the hybrid hydrogel bridging polymer, wherein the hybrid hydrogel is chitosan or chitosan derivatives and Polyethylene glycol cross-linked hydrogel is obtained by hybridizing inorganic nanoparticles; the polyethylene glycol is a polyethylene glycol whose terminal group is an aldehyde group; the bridged polymer includes biomacromolecules materials and inorganic nanoparticles; wherein the biomacromolecular material is chitosan, chitosan derivatives, gelatin or collagen;

[0022] The inorganic nanoparticles are silicon dioxide nanoparticles, hydroxyapatite nanoparticles, aluminum oxide nanoparticles or nano silver.

[0023] In this embodiment, the polyethylene glycol whose end group is an aldehyde group can be directly synthesized by RAFT, or can be obtained by reacting polyethylene glycol with a small molecule compound containing an aldehyde group. Aldehyd...

specific Embodiment approach 2

[0025] Embodiment 2: This embodiment is different from Embodiment 1 in that the chitosan derivative is carboxymethyl chitosan or hydroxyethyl chitosan.

specific Embodiment approach 3

[0026] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the polyethylene glycol has a molecular weight of 500-10k Da.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Adhesive strengthaaaaaaaaaa
Adhesive strengthaaaaaaaaaa
Login to View More

Abstract

A binder-type hydrogel and its preparation method and application are disclosed. The present invention belongs to the field of hydrogel, and aims to solve the problem that the mechanical strength of hydrogel is not enough in the application process of cartilage tissue engineering, and the hydrogel is easy to be lost from tissue. The binder-type hydrogel of the invention is a composite bridging polymer on the surface of a hybrid hydrogel, wherein the hybrid hydrogel is a hydrogel crosslinked by chitosan or a derivative of chitosan and polyethylene glycol, and inorganic nanoparticles are hybridized in the hydrogel, and the bridging polymer comprises a biomacromolecular material and inorganic nanoparticles. The preparation method comprise the following steps: 1, mixing that chitosan solutionand the polyethylene glycol solution to obtain a hydrogel; 2, mixing that biomacromolecular material solution and the inorganic nanometer particles to obtain a bridging polymer; and 3, the bridging polymer adheres to the surface of the hydrogel. The adhesive hydrogel of the invention is used for preparing a scaffold material in cartilage damage repair, and has excellent mechanical properties and adhesion strength due to the addition of inorganic nanoparticles.

Description

technical field [0001] The invention belongs to the field of hydrogels, in particular to a hydrogel with strong viscosity on a wet surface and its preparation and application. Background technique [0002] Currently, cartilage damage due to improper exercise is increasing. In addition, excessive walking and long-term weight bearing are common causes of osteoarticular cartilage defects. Once the articular cartilage is damaged, it cannot repair itself, and the prognosis is poor, and there is no specific treatment. At present, the research of cartilage tissue engineering has brought great hope for the treatment of cartilage damage. The three basic elements of tissue engineering are scaffold materials, seed cells and growth factors. The current scaffold materials are easy to lose from the tissue site, which seriously limits the clinical application of the scaffold materials. Therefore, it is imminent to develop a scaffold material with strong adhesion. [0003] Recently, "S...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/40A61L27/20A61L27/18A61L27/02A61L27/12A61L27/04A61L27/22A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56A61K47/36A61K47/10A61K47/02A61K47/04A61K47/42A61P19/04
CPCA61K47/02A61K47/10A61K47/36A61K47/42A61L27/025A61L27/047A61L27/12A61L27/18A61L27/20A61L27/222A61L27/24A61L27/50A61L27/52A61L27/54A61L27/56A61L2300/412A61L2400/12A61L2430/06A61P19/04C08L5/08C08L71/02
Inventor 朱飞燕熊建义梁仟朱天飞
Owner 朱飞燕
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com