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Eye drop composition containing nacre powder for relieving eye fatigue, preparation method and application

A technology of nacre powder and eye drops, which is applied in the field of medicine, can solve problems such as irreversible damage to the cornea, irritation of the cornea, and increased irritation, and achieve the effects of relieving eye fatigue, reducing irritation, and prolonging the action time Effect

Active Publication Date: 2020-12-22
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] During the later use of the eye drops of this formula, due to the solubilizer (Tween 80), solubilizer (ethanol) and preservatives (phenoxyethanol, benzalkonium chloride, ethylparaben, etc.) used in the formula Both are irritating to the cornea, especially preservatives may cause irreversible damage to the cornea
[0004] Another relevant literature reports that the pH of the formula will drop during long-term storage, which will further acidify and lead to increased irritation, which will increase the side effects when users use it later.

Method used

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  • Eye drop composition containing nacre powder for relieving eye fatigue, preparation method and application
  • Eye drop composition containing nacre powder for relieving eye fatigue, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment one, a kind of eye drop composition containing nacre powder can relieve eye fatigue

[0031] An eye drop containing carboxymethyl chitosan comprises active ingredients, auxiliary materials and solvents, wherein the active ingredients are composed of nacre powder, borneol, zinc gluconate and carboxymethyl chitosan. Wherein, the content of active ingredients is 27-36% of nacre powder, 0.01-0.05% of borneol, 0.11-0.34% of zinc gluconate and 1.0-3.0% of carboxymethyl chitosan in terms of mass percentage. The content of auxiliary materials in mass percentage is pH regulator sodium citrate 0.1-0.5%, osmotic pressure regulator sodium chloride 0.4%-0.8%, solubilizer ethanol 0.05%-1.2%, solubilizer polyoxyethylene sorbitan Monooleate 0.06-0.14%. The solvent is water for injection, or other oily solvents or water-containing emulsions can be used according to the situation.

[0032] Depending on the situation and the use and sales environment, preservatives can be add...

Embodiment 2

[0035] Example 2, a preparation method of an eye drop composition containing pearl layer powder that can relieve eye fatigue

[0036] It mainly includes the following three steps:

[0037] Step 1, the prescription amount of carboxymethyl chitosan is dissolved in part of the solvent under heating conditions;

[0038] Step 2, adding the prescription amount of auxiliary materials, zinc gluconate and nacre powder into the above solution, boiling and cooling down to below 60°C;

[0039] Step 3, dissolving the prescribed amount of borneol in ethanol and adding it to the solution obtained in Step 2, stirring evenly, adding the remaining part of the solvent, and filtering to obtain the product.

[0040] As an optimization, the temperature of the heating condition in step 1 is above 80° C., and part of the solvent refers to 70% of the recipe amount.

[0041] For further optimization, in step 2, the nacre powder is added in the form of a hydrolyzed liquid, the boiling time is 30 minut...

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Abstract

A liquid eye drop composition containing nacreous layer powder for relieving eye fatigue is provided. The liquid eye drop composition is characterized by comprising an active ingredient, adjuvant andsolvent, the active ingredient is composed of nacreous layer powder, borneol, zinc gluconate and carboxymethyl chitosan. The carboxymethyl chitosan used in the formula is a natural product, safe, non-toxic, and inherently preservative, which can make the new formula without or with less preservatives and reduce the irritation of the eye drops. At that same time, the eye drop composition doe not add the polyvinyl alcohol in the original drug, which can improve the problem that the pH drops dure the storage period of the drug, resulting in the eye irritation enhancement of the patient: the inventor found that the polyvinyl alcohol can catalyze the ester bond cleavage in the zinc gluconate, thereby dissociating the carboxyl group, so that the pH drops too fast. Furthermore, the use of carboxymethyl chitosan can also increase the viscosity of eye drops, which helps to prolong the action time of the drug, and can enhance the effect of relieving eye fatigue.

Description

technical field [0001] The invention relates to an eye drop, which belongs to the field of medicine. Background technique [0002] Existing eye drop composition containing nacre powder can relieve eye fatigue, it contains nacre powder, borneol, zinc gluconate, polyvinyl alcohol and osmotic pressure regulator (sodium chloride), pH regulator (citrate) sodium citrate), solubilizer (Tween 80), solubilizer (ethanol) and preservatives (phenoxyethanol, benzalkonium chloride, ethylparaben, etc.). [0003] During the later use of the eye drops of this formula, due to the solubilizer (Tween 80), solubilizer (ethanol) and preservatives (phenoxyethanol, benzalkonium chloride, ethyl paraben, etc.) used in the formula Both are irritating to the cornea, especially preservatives may cause irreversible damage to the cornea. [0004] In addition, relevant literature reports that the pH of the formula will drop during long-term storage, which will lead to further acidification and increase t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K35/618A61K47/36A61P27/02A61K31/045A61K31/315
CPCA61K9/0048A61K9/08A61K31/045A61K31/315A61K35/618A61K47/36A61P27/02A61K2300/00
Inventor 付欢延静万利鹏尹传忠陈璐王超
Owner 湖北远大天天明制药有限公司
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