Ginkgo leaf drop pill and preparation method thereof

A technology of leaf drop pills and ginkgo leaf, which is applied in the field of ginkgo leaf drop pills and its preparation, can solve the problems of ginkgo leaf drop pills with poor blood lipid regulation effect and low bioavailability, and achieve obvious blood lipid lowering effect, good effect, and obvious The effect of economic benefits

Inactive Publication Date: 2019-01-18
华玉海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is: the Ginkgo biloba dripping pills prepared by the existing method have poor blood lipid regulation effect and low bioavailability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] The present invention also provides a kind of preparation method of above-mentioned ginkgo leaf dripping pill, comprises the following steps:

[0032] a. Take dried ginkgo leaves, add 6-7 times the volume of ethanol solution with a mass concentration of 50-60%, then add sodium bicarbonate to adjust the pH to 8.5-10.5, place in an ultrasonic container, extract for 10-20min, and use Biofilm filtration, collecting the filtrate for the first time;

[0033] Add the filtered ginkgo leaves to 6-7 times the volume of ethanol solution with a mass concentration of 70-80%, then add sodium bicarbonate to adjust the pH to 8.5-10.5, place in an ultrasonic container, extract for 20-30min, and use biological Membrane filtration, collecting the filtrate for the second time;

[0034] Add the ginkgo leaves obtained by the second filtration to 6-7 times the volume of ethanol solution with a mass concentration of 50-60%, then add sodium bicarbonate to adjust the pH to 8.5-10.5, place it in...

Embodiment 1

[0044] Embodiment 1 adopts the inventive method to prepare ginkgo biloba dripping pill

[0045] The composition of the Ginkgo Leaf Dropping Pill comprises: 50 parts by weight of Ginkgo Leaf, 20 parts of Salvia Miltiorrhiza Extract, 10 parts of Grape Seed Oil, 20 parts of Tartary Buckwheat Powder, and 20 parts of Jinhuai Leaf Extract.

[0046] The preparation method of Ginkgo Leaf Dropping Pills is as follows:

[0047] a. Take dried ginkgo leaves, add 6 times the volume of ethanol solution with a mass concentration of 50%, then add sodium bicarbonate to adjust the pH to 8.5, place it in an ultrasonic container, extract for 10 minutes, and use biofilm filtration to collect the first time the filtrate;

[0048] Add the filtered ginkgo leaves to 6 times the volume of ethanol solution with a mass concentration of 70%, then add sodium bicarbonate to adjust the pH to 8.5, place in an ultrasonic container, extract for 20 minutes, and use biofilm filtration to collect the second filt...

Embodiment 2

[0054] Embodiment 2 Adopt the inventive method to prepare Ginkgo biloba dripping pills

[0055] The composition of the Ginkgo Leaf Dropping Pill comprises: 70 parts by weight of Ginkgo Leaf, 10 parts of Salvia Miltiorrhiza Extract, 5 parts of Grape Seed Oil, 10 parts of Tartary Buckwheat Powder, and 10 parts of Golden Sophora Leaf Extract.

[0056] The preparation method of Ginkgo Leaf Dropping Pills is as follows:

[0057] a. Take dried ginkgo leaves, add 7 times the volume of ethanol solution with a mass concentration of 60%, then add sodium bicarbonate to adjust the pH to 10.5, place it in an ultrasonic container, extract for 20 minutes, and use biofilm filtration to collect the first time the filtrate;

[0058] Add the filtered ginkgo leaves to 7 times the volume of ethanol solution with a mass concentration of 80%, then add sodium bicarbonate to adjust the pH to 10.5, place in an ultrasonic container, extract for 30 minutes, and use biofilm filtration to collect the seco...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparation, in particular to a ginkgo leaf drop pill and a preparation method thereof. The invention provides a ginkgo leaf drop pill for reducing blood lipid and a preparation method thereof, aiming at the problems of poor blood lipid regulating effect and low bioavailability of the ginkgo leaf drop pill prepared by the prior method. The preparation method of ginkgo dripping pills comprises the following steps: a, taking dried leaves of ginkgo, adding into ethanol solution, adopting ultrasonic extraction, adopting biofilm filtration, and extracting at least three times; mixing the collected filtrates, concentrating to obtain concentrated solution, and drying to obtain extract; ginkgo leaf drop pill is prepared by adding radix Salviae Miltiorrhizae extract, grape seed oil, tartary buckwheat powder and folium Sophorae Japonicae extract, matrix and p-aminobenzoic acid. As that method of the invention is use together withthe ultrasonic extraction and the biological membrane filtration, the extraction rate of the ginkgo biloba leaves can be improve, a special substrate is selected when preparing the dripping pill, andp-aminobenzoic acid is added, the drug dissolution rate is 10 times faster than that of the traditional method, and the economic benefit is remarkable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a ginkgo leaf dripping pill and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba, a plant of the genus Ginkgo. It contains flavonoids, terpenes, phenols, beneficial trace elements and 17 amino acids and other active ingredients. It has the functions of lowering serum cholesterol, increasing coronary blood flow, improving cerebral blood circulation, and Smooth muscle spasm, bronchial relaxation and pharmacological effects such as antibacterial. Clinically, it is not only used to treat cardiovascular and cerebrovascular diseases, but also has good effects on the nervous system and respiratory system. [0003] Although there are many active ingredients in Ginkgo biloba, the ginkgolic acid in it is a toxic ingredient. Therefore, Ginkgo biloba cannot be directly used for pharmaceuticals. Special...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61K9/20A61K47/18A61K47/36A61P3/06A61P39/06
CPCA61K36/16A61K9/2013A61K9/205A61K36/53A61K36/537A61K36/70A61K36/87A61K2236/333A61K2236/39A61K2236/53A61P3/06A61P39/06A61K2300/00
Inventor 华玉海
Owner 华玉海
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