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A kind of preparation method of sodium fructose diphosphate injection

A technology of sodium fructose diphosphate and injection, which is applied in the directions of microorganism-based methods, biochemical equipment and methods, medical preparations containing active ingredients, etc. Increase energy consumption and other issues to achieve the effect of reducing adverse reactions, reducing the production of related substances, and simplifying operations

Active Publication Date: 2020-12-08
BEIJING HUAJIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of using organic solvents are: on the one hand, it increases the production process steps and production costs, and increases energy consumption;
[0007] In a word, whether it is to make solid sodium fructose diphosphate through the fine-baking process, or to make solid sodium fructose diphosphate by the method in the Chinese patent whose application publication number is CN1650871A, a large amount of organic solvents are needed in the process; in addition, In the process of preparing sodium fructose diphosphate injection, it is necessary to dissolve the solid sodium fructose diphosphate and follow-up operations to obtain the target product-sodium fructose diphosphate injection. This process requires a certain period, and usually The solid sodium fructose diphosphate needs to be transported to the processing place of sodium fructose diphosphate injection, and the transportation cost is high during the process

Method used

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  • A kind of preparation method of sodium fructose diphosphate injection
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  • A kind of preparation method of sodium fructose diphosphate injection

Examples

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Comparison scheme
Effect test

Embodiment 1

[0046] A kind of preparation method of sodium fructose diphosphate injection, such as figure 1 shown, including the following steps:

[0047] S1. In parts by weight, 100 kg of disodium hydrogen phosphate, 100 kg of sodium dihydrogen phosphate, 200 kg of glucose and 10 kg of phosphoric acid are dissolved in water, stirred until completely dissolved, prepared into a reaction solution, and the pH of the reaction solution is controlled to be 5.0;

[0048] Mix the prepared reaction liquid with 1000L of beer yeast as the material liquid, stir, and enzymatic reaction occurs under the action of beer yeast to convert glucose and other materials into sodium fructose diphosphate. During the stirring process, control the temperature at 35°C, The pH value of the solution is 2.0;

[0049] After stirring for 1 hour, take the feed liquid every hour and measure the pH value and the concentration of inorganic phosphorus. When the concentration of inorganic phosphorus is less than or equal to 3...

Embodiment 2

[0069] A kind of preparation method of sodium fructose diphosphate injection, such as figure 1 shown, including the following steps:

[0070] S1. In parts by weight, 500 kg of disodium hydrogen phosphate, 200 kg of sodium dihydrogen phosphate, 600 kg of glucose and 20 kg of phosphoric acid are dissolved in water, stirred until completely dissolved, and prepared into a reaction solution, and the pH of the reaction solution is controlled to be 7.0;

[0071] Mix the prepared reaction liquid with 3000L of beer yeast as the material liquid, stir, and enzymatic reaction occurs under the action of beer yeast to convert glucose and other materials into sodium fructose diphosphate. During the stirring process, control the temperature at 38°C, and the material The pH value of the liquid is about 7.0;

[0072] After stirring started 1 hour, take feed liquid and measure pH value and inorganic phosphorus concentration every hour, when inorganic phosphorus concentration≤300 μ g / ml (w / v), sti...

Embodiment 3

[0091] A kind of preparation method of sodium fructose diphosphate injection, such as figure 1 shown, including the following steps:

[0092] S1. In parts by weight, dissolve 300 kg of disodium hydrogen phosphate, 150 kg of sodium dihydrogen phosphate, 400 kg of glucose and 15 kg of phosphoric acid in water, stir until completely dissolved, and prepare a reaction solution. During the process, control the pH of the reaction solution to around 6.0;

[0093] Mix the prepared reaction solution with 2000L of brewer's yeast as feed liquid, stir, and convert glucose and other materials into fructose sodium diphosphate through enzymatic reaction under the action of brewer's yeast. During the stirring process, control the temperature at 40°C, The pH value of the liquid is about 4.5;

[0094] After stirring started for 1 hour, the pH value and the concentration of inorganic phosphorus were measured by taking the feed liquid every hour. When the concentration of inorganic phosphorus wa...

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Abstract

Provided are a preparation method for a solution containing fructose sodium diphosphate, use thereof, and a preparation method for a fructose sodium diphosphate injection. The preparation method for the solution containing fructose sodium diphosphate comprises performing solid-liquid separation on a yeast reaction solution containing fructose sodium diphosphate, anion exchange resin extraction, decolorization, reverse osmosis treatment and sterilization treatment. The yeast reaction solution is obtained by contacting a sugar-containing material containing glucose and phosphoric acid with yeast. Other dosage forms such as fructose sodium diphosphate injections or fructose sodium diphosphate oral solutions can be further prepared using said method. The preparation method has advantages of greatly reducing the dosage of an organic solvent and reducing the production cost.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, more specifically, it relates to a preparation method of sodium fructose diphosphate injection. Background technique [0002] Fructose 1,6-diphosphate (FDP), an intermediate product of glycolysis, regulates several enzymatic reactions in cells by activating phosphofructokinase, pyruvate kinase, and lactate dehydrogenase. The concentration of FDP in different cells is not the same, the concentration of FDP in human erythrocytes is 6-10mg / L cells. Biochemical studies in vivo and in vitro showed that pharmacological doses of FDP can act on cell membranes. Promote the uptake of potassium in the circulation by cells and stimulate the production of high-energy phosphoric acid and 2,3-bisphosphoglycerol in cells. In addition, FDP can reduce the hemolysis of red blood cells caused by mechanical trauma and inhibit the production of oxygen free radicals caused by chemical stimulation. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/7024A61P3/12A61P9/10C12P19/12C12R1/865
CPCA61K9/0019A61K9/08A61K31/7024A61P3/12A61P9/10C12P19/12
Inventor 王硕王洪萍
Owner BEIJING HUAJIN PHARM CO LTD
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