Thermosensitive three-stage color-changing medical antipyretic patch and preparation method thereof

Abstract

The invention discloses a novel medical antipyretic patch, in particular to a thermosensitive three-stage color-changing medical antipyretic patch and a preparation method thereof, wherein the thermosensitive three-stage color-changing medical antipyretic patch can directly observe the temperature change of a human body according to the color change in the use process. The antipyretic patch comprises a spunlace nonwoven substrate, a thermosensitive hydrogel layer and a PP separating film, wherein the thermosensitive hydrogel is coated on the spunlace nonwoven substrate, and then the PP separating film is coated on the thermosensitive hydrogel. The invention uses the mixture of crystal violet lactone, fatty alcohol and hydrated cobalt salt as the leuco dye, the mixture of tetradecanoic acid, hexadecanoic acid and stearic acid as the electron acceptor material, and optimizes the proportion of the components to effectively improve the color-changing sensitivity of the thermosensitive material; By adding carrageenan, konjac gum and nano-silica into hydrogel, the permeability and mechanical properties of hydrogel can be effectively improved, and the practicability is stronger.

Description

technical field [0001] The invention relates to a new type of medical antipyretic patch, in particular to a heat-sensitive three-stage color-changing medical antipyretic patch that can visually observe the change of human body temperature according to the change of color during use, and belongs to the technical field of medical devices. Background technique [0002] Children's fever is one of the main symptoms that threaten children's health, especially low-grade fever in young children. On the one hand, it is difficult for young children to express their subjective feelings. On the other hand, low-grade fever is often easily overlooked due to factors such as the environment. The delay of the disease will affect the normal development of the child at the slightest, and will cause life-threatening to the child at the worst; The color change of the patient can understand the patient's physical condition, and on the other hand, it can quickly cool down for treatment. [0003] ...

AI Technical Summary

Problems solved by technology

[0004] However, the color-changing antipyretic stickers currently on the market can only change two colors, that is, they can only distinguish between fever and no fever, and cannot effectively highlight low-grade fever and high-grade fever. The treatment options for low-grade and high-grade fever are very different, especially For special populations such as infants, in order not to affect their normal growth and development, it is generally not recommended to use drugs unless it is absolutely necessary. Therefore, it is more practical to develop a three-level color-changing antipyretic patch that can highlight low-grade fever and high-grade fever; in addition, The heat-sensitive color-changing materials currently used are easy to react with external environmental factors such as water, and their physical and chemical properties are prone to change without protection, resulting in product failure. Therefore, how to solve the problem that conventional heat-sensitive materials are not easy to store and easy The defect of deterioration and color development affected by the environment is the method of research in this industry

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