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Biomimetic spider silk polyamino acid bioelastomer material and preparation method thereof

An elastomer material, polyamino acid technology, applied in the field of biomimetic materials, can solve problems such as easy gelation, difficult chemical synthesis, etc., and achieve the effects of simple and easy method, good biocompatibility, and easy control.

Active Publication Date: 2021-06-04
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a bionic spider silk polyamino acid bioelastomer material and its preparation method, aiming to solve the problem of difficult chemical synthesis of existing polyamino acid (polypeptide) bioelastomers and the problem of easy gelation during the synthesis process

Method used

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preparation example Construction

[0016] And, the embodiment of the present invention also provides a preparation method of biomimetic spider silk polyamino acid bioelastomer material, comprising the following steps:

[0017] S01. Provide amino acid-N-internal carboxylic acid anhydride and B blocks with primary amines at both ends, wherein the amino acid in the amino acid-N-internal carboxylic anhydride is at least one of L-alanine and L-glycine One, the B block is at least one of polyethylene oxide, polypropylene oxide, polycaprolactone, polytetrahydrofuran, polydimethylsilane, and hydrogenated polybutadiene;

[0018] S02. The A block and the B block with primary amines at both ends are dissolved in an organic solvent containing lithium salt, and polymerized to obtain a bionic spider silk polyamino acid bioelastomer material, and the reaction temperature is 10- 30°C, the reaction time is 4-72h.

[0019] Specifically, in the above step S01, the amino acid-N-internal carboxylic anhydride is used as the raw mat...

Embodiment 1

[0027] A preparation method of poly(L-alanine)-polydimethylsilane-poly(L-alanine), comprising the following steps:

[0028] Dissolve 3g of L-alanine-N-internal carboxylic acid anhydride in 50mL of anhydrous dimethyl sulfoxide containing 1mol / L LiBr, and add 3g of polydimethylsilane with a molecular weight of 27000g / mol and an amino group at the end under stirring conditions , stirred and reacted at 25°C for 48h, settled the reaction mixture with 300mL ether, filtered, washed 3 times with ether, and dried in vacuum at 25°C for 24h to obtain poly(L-alanine)-polydimethylsilane-poly( L-alanine) with a tensile strength of 4.2 MPa and an elongation at break of 200%.

Embodiment 2

[0030] A preparation method of poly(L-alanine)-polytetrahydrofuran-poly(L-alanine), comprising the following steps:

[0031]Dissolve 3g of L-alanine-N-internal carboxylic acid anhydride in 50mL of anhydrous tetrahydrofuran containing 0.5mol / L LiBr, add 4g of polytetrahydrofuran with a molecular weight of 10,000g / mol and terminal amino groups under stirring conditions, and stir at 20°C After reacting for 24h, the reaction mixture was settled with 300mL ether, filtered, washed 3 times with ether, and vacuum-dried at 25°C for 24h to obtain poly(L-alanine)-polytetrahydrofuran-poly(L-alanine). The tensile strength was 5.3 MPa and the elongation at break was 150%.

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Abstract

The invention provides a bionic spider silk polyamino acid bioelastomer material, which is an ABA triblock copolymer composed of a hard segment A block and a soft segment B block, wherein , the A block has a β-sheet structure, and the A block is at least one of poly-L-alanine, poly-L-glycine, L-alanine and L-glycine copolymer, the The B block is at least one of polyethylene oxide, polypropylene oxide, polycaprolactone, polytetrahydrofuran, polydimethylsilane, and hydrogenated polybutadiene.

Description

technical field [0001] The invention belongs to the field of bionic materials, in particular to a bionic spider silk polyamino acid bioelastic material and a preparation method thereof. Background technique [0002] Thermoplastic elastomers have the excellent elasticity of elastomers and the processability of thermoplastic polymers, and are usually ABA-type tri-block copolymers composed of hard segments and soft segments. The hard segment is generally composed of a semi-crystalline polymer or a polymer with a high glass transition temperature. At present, commercialized thermoplastic elastomers include polystyrene-polybutadiene-polystyrene copolymer (SBS), polystyrene-polyisoprene-polystyrene copolymer (SBS), etc., but these Elastomers are mainly synthesized from petroleum resources and are not biodegradable. However, most of the polyamino acid (polypeptide) bioelastomers used in practice come from animal bodies, and there are still some challenges through chemical synthes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G69/10C08L77/04
CPCC08G69/10C08L77/04
Inventor 胡金莲顾林蒋元章
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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