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Application of piperaquine phosphate in the preparation of drugs for for treating lipid metabolism disorder and hyperlipidemia

A technology of piperaquine phosphate and lipid metabolism is applied in the application field of piperaquine phosphate in the preparation of drugs for treating lipid metabolism disorders and hyperlipidemia, which can solve the problems of unreported treatment of hyperlipidemia, and achieve good treatment. effect, effect of reducing content

Active Publication Date: 2019-01-11
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Piperaquine phosphate is an oral long-acting antimalarial drug, which is mainly used for the prevention and treatment of malaria. It has a good control effect on falciparum malaria and vivax malaria, but it has not been reported for the treatment of hyperlipidemia

Method used

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  • Application of piperaquine phosphate in the preparation of drugs for for treating lipid metabolism disorder and hyperlipidemia
  • Application of piperaquine phosphate in the preparation of drugs for for treating lipid metabolism disorder and hyperlipidemia
  • Application of piperaquine phosphate in the preparation of drugs for for treating lipid metabolism disorder and hyperlipidemia

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Experimental program
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Embodiment 1

[0024] In this embodiment, the animal experiments and results of piperaquine phosphate as a drug for treating lipid metabolism disorders, especially hyperlipidemia will be used to illustrate its new application in the pharmaceutical field.

[0025] 1. Materials

[0026] 1.1 Drugs to be tested

[0027] Piperaquine phosphate, production unit: Chongqing Southwest Pharmaceutical Second Factory Co., Ltd.; batch number: Y180504; dosage form: powder, dissolved in purified water to make 1.88mg·mL -1 , 3.76mg·mL -1 and 7.52mg·mL -1 Concentrated drug solution, respectively used in low dose, middle dose and high dose groups, that is, the concentration of the drug is 1.88 mg·mL -1 , 3.76mg·mL -1 and 7.52mg·mL -1 .

[0028] 1.2 Experimental animals

[0029] ob / ob mice are leptin gene knockout mice. Even if they are given a normal diet, they can induce obesity and even obesity-related high TC and high TG blood. It is a stable animal model of hyperlipidemia.

[0030] 10-week-old male...

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Abstract

The invention relates to the pharmaceutical field, in particular to the application of piperaquine phosphate in the preparation of drugs for treating lipid metabolism disorder and hyperlipidemia. Piperaquine phosphate can significantly reduce serum TC and TG levels, significantly reduce blood lipid, and can significantly reduce body weight, and no obvious toxic and side effects, which can be usedto treat hyperlipidemia, and can be used in the preparation of hyperlipidemia drugs.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of piperaquine phosphate in the preparation of drugs for treating lipid metabolism disorders and hyperlipidemia. Background technique [0002] Hyperlipidemia is a disease in which one or several lipid structures in the plasma are unbalanced due to systemic fat metabolism disorders, that is, excessive or high density of total cholesterol (TC) or triglyceride (triglyceride, TG) in the blood. Lipoprotein cholesterol (HDL-C) is too low, and modern medicine is called dyslipidemia. [0003] The 2012 national survey showed that the overall prevalence of dyslipidemia in Chinese adults was as high as 40.40%. The increase of serum cholesterol level in the population will lead to an increase of about 9.2 million cardiovascular events in my country between 2010 and 2030. The prevalence of hypercholesterolemia in children and adolescents in my country has also increased significantly...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P3/00A61P3/06A61P3/10A61P9/10A61P1/16
CPCA61K31/496A61P1/16A61P3/00A61P3/06A61P3/10A61P9/10
Inventor 李常青宋健平徐勤
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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